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Human Polyclonal ARPC2 Primary Antibody for IHC (p), IHC - ABIN249530
Isogai, van der Kammen, Leyton-Puig, Kedziora, Jalink, Innocenti: Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex. in Journal of cell science 2015
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Human Polyclonal ARPC2 Primary Antibody for IHC, ELISA - ABIN184748
Welch, DePace, Verma, Iwamatsu, Mitchison: The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. in The Journal of cell biology 1997
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Cow (Bovine) Polyclonal ARPC2 Primary Antibody for WB - ABIN2787750
Cai, Marshall, Uetrecht, Schafer, Bear: Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. in Cell 2007
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WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells
In the association analysis of 110 gastric cancer tissues, ARPC2 showed significant associations with large tumor size, lymph node invasion, and high tumor stage. In addition, ARPC2-positive patients exhibited lower RFS and OS rates compared with ARPC2-negative patients. We thus identify that ARPC2 plays an aneretic role in human gastric cancer and provided a new target for gastric cancer therapy.
Downregulation of the ARP2 (show ACTR2 Antibodies)/3 complex signaling pathway, a common final pathway for multiple signaling cascades that regulate the actin cytoskeleton, would compromise the structural stability of spines, leading to their loss. In concert with findings from deletion of the ARP2 (show ACTR2 Antibodies)/3 complex in mice, these findings support the idea that spine deficits in the DLPFC may contribute to subcortical hyperdopaminergia in schizophrenia.
Recent reports now demonstrate a novel aspect of the ARP2 (show ACTR2 Antibodies)/3 complex and the nucleating-promoting factors in the maintenance of endothelial barrier function and junction remodeling of established endothelial cell junctions.
FOXF1 (show FOXF1 Antibodies) repressed cell growth and expression of collagen-1 and actin-related protein 2 (show ACTR2 Antibodies)/3 complex, subunit 2 (show CCT2 Antibodies).
The Arp2 (show ACTR2 Antibodies)/3 complex is recruited to invading Rickettsia parkeri and is required for efficient invasion.
Filopodia initiation: focus on the Arp2 (show ACTR2 Antibodies)/3 complex and formins
Endogenous Nogo-B (show RTN4 Antibodies), which may exert its effects through ARPC 2/3 and MYL-9 (show MYL9 Antibodies), is necessary for the migration and contraction of airway smooth muscle cells.
The results identify Arp2/3 complex as a key factor in the generation of the dynamic actin cluster during mitosis.
Arp2/3 complex genes have roles in actin organization and possibly in cancer phenotypes
Gmfg (show GMFG Antibodies) has two separate binding sites on Arp2 (show ACTR2 Antibodies)/3 complex with high (site 1) and low (site 2) affinity. X-ray crystallography revealed closely located positions of Gmfg (show GMFG Antibodies) in site 1. Molecular dynamics simulation allowed determining the binding pocket for Gmfg (show GMFG Antibodies) in site 2.
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.
actin related protein 2/3 complex, subunit 2, 34kDa
, actin related protein 2/3 complex subunit 2
, actin-related protein 2/3 complex subunit 2
, arp2/3 complex 34 kDa subunit
, ARP2/3 protein complex subunit 34
, actin related protein 2/3 complex, subunit 2 (34 kD)