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Human FGF1 Protein expressed in Escherichia coli (E. coli) - ABIN2001899
Hebart, Einsele: Diagnosis and treatment of cytomegalovirus infection. in Current opinion in hematology 1999
Show all 2 Pubmed References
Human FGF1 Protein expressed in Human - ABIN2452191
Zakrzewska, Marcinkowska, Wiedlocha: FGF-1: from biology through engineering to potential medical applications. in Critical reviews in clinical laboratory sciences 2008
Our study suggests that the genetic variants of FGF1 rs34011, more so than FGF2 (show FGF2 Proteins) rs2922979, may play a role in PE pathogenesis in Tunisian women.
FGF1 and 2 strongly prevent the osteogenic commitment and differentiation of hBMSCs.
Transfected FGF1 promotes angiogenic proliferation.
These observations suggest a crucial role for cancer-associated fibroblasts and fibroblast growth factor-1/fibroblast growth factor receptor 4 (show FGFR4 Proteins) signaling in the progression of ovarian cancer. the expression level of Snail1 (show SNAI1 Proteins) and MMP3 (show MMP3 Proteins) was reduced, while the expression level of E-cadherin (show CDH1 Proteins) increased
Enzyme-linked immunosorbent assay was used to detect the levels of chemokine (C-X-C motif) ligand 12, chemokine (C-X-C motif) ligand 7, hepatocyte growth factor, and fibroblast growth factor 1 in the supernatants of the laryngeal squamous cell carcinoma and control cells.
fibroblast growth factor 1 (FGF1) to be synergistically induced by heat shock and wounding.
The results indicate that suramin blocks the interaction between hFGF1 and FGFR2 (show FGFR2 Proteins) D2.
activation of AurA (show AURKA Proteins) kinase through FGF1/FGFR (show FGFR2 Proteins) signaling axis sustains the stem cell characteristics of glioblastoma cells.
Study showed that both aFGF and bFGF (show FGF2 Proteins) were highly expressed in cervical cancer tissues. In tumors of higher clinical stages, the expression of these factors was further enhanced, suggesting that they play a role in facilitating cervical cancer cell proliferation.
FGF1 may play a role in the pathogenesis of T2 diabetes mellitus.
FGF1 and FGF7 (show FGF7 Proteins) may be involved differently in the process of follicle maturation and CL formation, which is strongly dependent on angiogenesis
Western Blot analysis revealed a decrease in FGF-1 protein expression after day 40 in the porcine umbilical cord during pregnancy
the HDAC3 (show HDAC3 Proteins)-N-CoR (show NCOR1 Proteins) corepressor complex leaves the Fgf1b promoter and a complex involving the translocated CRTC1 (show CRTC1 Proteins), phosphorylated CREB (show CREB1 Proteins), and histone acetyltransferase CBP (show CREBBP Proteins) induces transient transcription.
lncRNA-Map2k4 is the target gene of miR-199a, and its down-regulation promotes miR-199a expression in neurons. miR-199a targeted regulation of FGF1 expression in neurons.
clearly demonstrate the different specificity of FGF12 (show FGF12 Proteins)-FGFR1c2 and FGF22 (show FGF22 Proteins)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling
The study supports a pro-adipogenic role for betaKlotho (show KLB Proteins) in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR (show FGFR2 Proteins)-betaKlotho (show KLB Proteins) axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy.
Data suggest that Fgf1-mediated signaling represents an important signaling cascade related to adipogenesis and visceral adiposity; expression of Fgf1 (fibroblast growth factor 1) and Fgfr1 (fibroblast growth factor receptor 1 (show FGFR1 Proteins)) is up-regulated in adipose tissue of obese mice (both obese mice due to high-fat diet and obese mice due to genetic deletion of leptin (show LEP Proteins)).
Study presents a transcript profiling of remyelinated multiple sclerosis lesions and identified FGF1 as a promoter of remyelination
Nucleolin-FGF1 interaction is critical for the intranuclear phosphorylation of FGF1 by PKCdelta and thereby the regulation of nuclear export of FGF1.
parenteral delivery of a single dose of recombinant FGF1 (rFGF1) results in potent, insulin (show INS Proteins)-dependent lowering of glucose levels in diabetic mice that is dose-dependent but does not lead to hypoglycaemia
Although FGF1 transgenic mice had a normal phenotype with unperturbed kidney structure, they showed a severely inhibited kidney repair after unilateral ischemia/reperfusion. This was manifested by a strong decrease of postischemic kidney size and weight.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.
beta-endothelial cell growth factor
, endothelial cell growth factor, alpha
, endothelial cell growth factor, beta
, fibroblast growth factor 1
, heparin-binding growth factor 1
, EDGF II
, acidic eye-derived growth factor II
, acidic fibroblast growth factor
, endothelial cell growth factor beta and alpha chains
, endothelial growth factor
, fibroblast growth factor, acidic
, heparin-binding growth factor 1 isoform 1 proprotein
, Heparin-binding growth factor 1
, acidic fgf
, acidic fibroblast growth factor, aFGF
, alpha-endothelial cell growth factor
, endothelial cell growth factor
, fibroblast growth factor 1 (acidic)
, Fibroblast growth factor 1 (heparin binding)
, Acidic fibroblast growth factor