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anti-Mouse (Murine) FGF19 Antibodies:
anti-Rat (Rattus) FGF19 Antibodies:
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Human Monoclonal FGF19 Primary Antibody for ELISA, WB - ABIN523342
Shang, Guo, Honda, Saumoy, Salen, Xu: FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels. in Journal of lipid research 2013
ileal FGF15/19 to hepatic FGFR4 (show FGFR4 Antibodies) axis is activated and promotes liver regeneration (LR) after partial hepatectomy (PH) in mice, supporting the potential of ileal FGF15/19 to hepatic FGFR4 (show FGFR4 Antibodies) axis-targeted therapy to enhance LR after PH
FRS2alpha (show FRS2 Antibodies)-mediated pathways are essential for the FGF15/FGF19-FGFR4 (show FGFR4 Antibodies) signaling axis to control bile acid homeostasis.
Together, our results show that SuFu (show SUFUH Antibodies) promotes cerebellar radial precursor differentiation to neurons. SuFu (show SUFUH Antibodies) function is mediated in part by GLI3R and down-regulation of Fgf15 expression.
Results show a reciprocal regulation of adiponectin and FGF19 gene expression in mice.
Tumorigenicity was assessed in three mouse models (db/db (show LEPR Antibodies), diet-induced obese, and multi-drug resistance 2 [Mdr2 (show ABCB4 Antibodies)]-deficient) following continuous exposure to FGF19 or FGF15 via adeno (show ADORA2A Antibodies)-associated viral-mediated gene delivery.
These data identify hypothalamic Fgf15 as a regulator of glucagon (show GCG Antibodies) secretion.
Fgf15 is the sonic hedgehog (show SHH Antibodies) downstream signal to control thalamic regionalization, neurogenesis, and neuronal differentiation by regulating the expression and mutual segregation of neurogenic and proneural regulatory genes.
human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (show NR1H4 Antibodies) target genes Fgf15 and Shp (show LAMC1 Antibodies) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (show NR1H4 Antibodies) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota
This study demonstrates that the FGF19-SHP (show LAMC1 Antibodies)-LSD1 (show KDM1A Antibodies) axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.
The elevation in circulating levels of adiponectin and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT knockout mice.
Study showed that FGF19 amplification is a genetic event in Chinese lung squamous cell carcinoma (LSCC) patients, with a frequency of 37.5%. FGF19 amplified LSCC cells express relatively higher levels of FGF19 mRNA expression, and downregulation of FGF19 expression can induce significant cell killing effects in vitro and in vivo.
FGFR4 (show FGFR4 Antibodies)/FGF19 autocrine signaling mediates the survival of a subset of basal-like breast cancer cells
FGF19 copy number may increase in hepatocellular carcinoma accompanying a complete response to sorafenib treatment
Study demonstrates that elevated FGF19 expression or hyperactivation of FGF19/FGFR4 (show FGFR4 Antibodies) signaling in hepatocellular carcinoma cells is one of the main mechanisms of sorafenib resistance.
This is the first study to elucidate FGF19/FGFR4 (show FGFR4 Antibodies) signaling in favor of hepatocellular carcinoma cells developing from fatty liver
High expression of FGF19 is associated with hepatocellular carcinoma.
Findings show that FGF19 provides a cytoprotective role against ER stress by activating a FGFR4 (show FGFR4 Antibodies)-GSK3beta-Nrf2 (show GABPA Antibodies) signaling cascade, suggesting targeting this signaling node as a candidate therapeutic regimen for hepatocellular carcinoma (HCC (show FAM126A Antibodies)) management.
Fibroblast growth factor 19 levels in human portal blood are higher than in arterial blood. Fibroblast growth factor 19 is released by the portal-drained viscera under fasted steady state conditions.
serum FGF19 and FGF21 (show FGF21 Antibodies) and hepatic Klotho (show KL Antibodies) expression are inversely associated with hepatic damage in children with NAFLD (show TSC2 Antibodies)
Administering FGF19, or suitable mimetic, as a pharmacological intervention to increase circulating levels of FGF19 and suppress BA synthesis by inhibiting CYP7A1 (show CYP7A1 Antibodies) gene expression is likely to provide therapeutic benefits for many PBC (show DLAT Antibodies) patients
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
fibroblast growth factor 19
, fibroblast growth factor 15