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Human FGF21 ELISA Kit for Sandwich ELISA - ABIN857064
Chen, Zhao, Wan, Ran, Qin, Wang, Gao, Shu, Zhang, Liu, Zhang, Zhu, Mi: Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial. in Pharmacological research : the official journal of the Italian Pharmacological Society 2015
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Human FGF21 ELISA Kit for Sandwich ELISA - ABIN612700
Nishimura, Nakatake, Konishi, Itoh: Identification of a novel FGF, FGF-21, preferentially expressed in the liver. in Biochimica et biophysica acta 2000
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Mouse (Murine) FGF21 ELISA Kit for Sandwich ELISA - ABIN2859244
Liu, Pan, Chen, Yang, Zhao, Jia, Zhu, Zhang, Gao, Li, Han, Duan: Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy. in Scientific reports 2015
Human FGF21 ELISA Kit for Sandwich ELISA - ABIN2684258
Suzuki, Lee, Vázquez-Medina, Viscarra, Crocker, Ortiz: Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals. in General and comparative endocrinology 2015
Mouse (Murine) FGF21 ELISA Kit for Sandwich ELISA - ABIN1081421
Min, Bae, Jung, Choi, Kim, Kim, Jeon, Kim, Lee, Park: Orphan nuclear receptor Nur77 mediates fasting-induced hepatic fibroblast growth factor 21 expression. in Endocrinology 2014
Human FGF21 ELISA Kit for Sandwich ELISA - ABIN418605
Xu, Niu, Yu, Xia, Gong, Wang: Associations between FGF21, osteonectin and bone turnover markers in type 2 diabetic patients with albuminuria. in Journal of diabetes and its complications 2016
Pig (Porcine) FGF21 ELISA Kit for Sandwich ELISA - ABIN649220
Varady, Ringseis, Eder: Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigs. in Lipids in health and disease 2012
Mouse (Murine) FGF21 ELISA Kit for Competition ELISA - ABIN2761940
Bae, Min, Kim, Lee, Park: Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH. in Biochemical and biophysical research communications 2014
Cow (Bovine) FGF21 ELISA Kit for Sandwich ELISA - ABIN1000145
Farney, Mamedova, Coetzee, KuKanich, Sordillo, Stoakes, Minton, Hollis, Bradford: Anti-inflammatory salicylate treatment alters the metabolic adaptations to lactation in dairy cattle. in American journal of physiology. Regulatory, integrative and comparative physiology 2013
cholestasis could induce FGF21 expression in FXR (show NR1H4 ELISA Kits) dependent manner
Serum concentrations of FGF21 are elevated in patients with non-HIV lipodystrophy with adipose tissue and liver being potential sources of increased production. TG and fibrate treatment are independent positive predictors of circulating FGF21.
FGF21 concentration in plasma is increased in patients with obesity, insulin (show INS ELISA Kits) resistance, and metabolic syndrome. Recent findings suggest that such increment protects tissue from an increased oxidative stress environment. (Review)
FGF21 appears to act in a paracrine manner to increase glucose uptake under low insulin (show INS ELISA Kits) conditions, but it does not contribute to the resistance to diet-induced obesity.
Insulin (show INS ELISA Kits) rather than glucose per se increases total and bioactive FGF21 in the postprandial period in adult humans.
FGF21 has a role in promoting remyelination in the central nervous system
FGF21 genotypes may interact with dietary carbohydrate/fat intake on changes in central adiposity and body fat composition. A low-calorie, high-carbohydrate/low-fat diet was beneficial for overweight or obese individuals carrying the carbohydrate intake-decreasing allele of the FGF21 variant to improve body composition and abdominal obesity.
serum FGF19 (show FGF19 ELISA Kits) and FGF21 and hepatic Klotho (show KL ELISA Kits) expression are inversely associated with hepatic damage in children with NAFLD (show TSC2 ELISA Kits)
Higher vitamin D status, but not FGF21, was associated with greater postprandial glucose oxidation and improved insulin (show INS ELISA Kits) sensitivity in metabolic syndrome.
dietary protein dilution promotes improved glucose homeostasis through an select nonessential amino acids insufficiency-induced liver NUPR1 (show NUPR1 ELISA Kits)/FGF21 axis
The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
This study demonstrates that FGF21 action is necessary to achieve the full metabolic benefits of exercise during chronic HF feeding.
mTORC1 mediated many of the beneficial actions of FGF21 in vitro, including UCP1 (show UCP1 ELISA Kits) and FGF21 induction, increased adiponectin secretion, and enhanced glucose uptake without any adverse effects on insulin (show INS ELISA Kits) action.
Data suggest that expression of Fgf21 in liver responds acutely to dietary protein intake; low-protein high-carbohydrate diet induces Fgf21 expression; high-protein low-carbohydrate diet reduces Fgf21 expression; Fgf21 expression/secretion in cultured hepatocytes appears to be controlled by glucose but not amino acids.
These findings reveal a previously unappreciated anti-inflammatory role for FGF21 in adipose tissue, but do not support that FGF21 is necessary for exercise-mediated anti-inflammatory effects.
our results reveal that ERRgamma (show ESRRG ELISA Kits), induced via activation of the hepatic CB1 (show CNR1 ELISA Kits) receptor, is a regulator of hepatic FGF21 gene expression and secretion.
OPA1 (show MED12 ELISA Kits) mutant mice are resistant to age- and diet-induced weight gain and insulin (show INS ELISA Kits) resistance, by mechanisms that involve activation of endoplasmic reticulum stress and secretion of fibroblast growth factor 21 (FGF21) from skeletal muscle, resulting in increased metabolic rates and improved whole-body insulin (show INS ELISA Kits) sensitivity.
FGF21 is not critical for bone homeostasis or actions of PPARalpha (show PPARA ELISA Kits) and PPARgamma (show PPARG ELISA Kits).
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21