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Mouse (Murine) FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN1888798
Stone, Wanders, Orgeron, Cortez, Gettys: Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. in Diabetes 2014
Mouse (Murine) FGF21 Protein expressed in Human Cells - ABIN2007779
Arner, Pettersson, Mitchell, Dunbar, Kharitonenkov, Rydén: FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. in FEBS letters 2008
Show all 3 Pubmed References
These findings suggested that the serum FGF21 levels could be involved in a complex adaptive response to insulin (show INS Proteins) secretion and glucose metabolism in humans.
Taking together from both physiological and genetic levels, we suggest that FGF21 is inversely associated with regional bone density.
besides the NF-kappaB pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway.
ChREBP and FGF21 constitute a signaling axis likely conserved in humans that mediates (show MLXIPL Proteins)an essential adaptive response to f (show MLXIPL Proteins)ructose ingestion that may participate in the pathogenesis of NAFLD and liver fibrosis.
Excess dietary carbohydrate, but not fat, led to markedly increased FGF21 secretion in humans, notably without protein restriction, and affected glucose and lipid homeostais.
In patients with coronary artery disease at baseline, an elevated serum FGF21 level was associated with development of a major adverse cardiovascular event in the future.
Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family that functions as an endocrine hormone which regulates carbohydrate and lipid metabolism. It is involved in maintaining of energy homeostasis and adaptation to starvation and low temperature.
FGF21 is a good predictor of acute-on-chronic liver failure and organ failure, is quite specific for cirrhosis, and seems independent of etiology and systemic inflammation.
FGF-21 could regulate the immune response indirectly by influencing the glucose uptake of activated monocytes cells.
FGF21 levels were reduced after energy-restricted treatments and severely increased after bariatric surgery, independently of the weight reduction magnitude, insulin (show INS Proteins) sensitivity or ketosis; therefore, FGF21 appears to be a marker of severe nutritional stress
The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
results demonstrate that fibroblast growth factor 21 reduces the increased expression of a subset of genes in the liver in response to endoplasmic reticulum stress
Lack of FGF21 enhances the susceptibility to the development of obesity-related cardiomyopathy.
The acute increase in circulating FGF21 following fructose gavage was absent in ChREBP (show MLXIPL Proteins) knockout mice. Induction of ChREBP (show MLXIPL Proteins)-beta and its glycolytic, fructolytic, and lipogenic gene targets were attenuated in FGF21 knockout mice fed high-fructose diets.
Data, including data from studies using knockout mice, suggest that control of whole-body energy expenditure by Gcgr (show GCGR Proteins) agonism requires intact Fxr (show NR1H4 Proteins) signaling and Fgf21 secretion in liver. (Gcgr (show GCGR Proteins) = glucagon receptor (show GCGR Proteins) glucagon (show GCG Proteins); Fxr (show NR1H4 Proteins) = farnesoid X receptor (show xpr1 Proteins); Fgf21 = fibroblast growth factor-21)
FGF-21 has anti-inflammatory effects in Type 2 diabetes mellitus
These data suggest that Fgf21 acts as one of intrathymic cytokines in the neonatal and juvenile thymus, involving thymocyte development in a beta (show SUCLA2 Proteins)-Klotho (show KLB Proteins)-independent manner.
During pregnancy, both systemic and cardiac-produced Fgf21 act on the heart, leading to the normal physiological cardiac changes that are associated with pregnancy.
our results demonstrated that FGF21 promotes cell cycle exit and enhances myogenic differentiation of C2C12 cells. This study provided new evidence that FGF21 promotes myogenic differentiation, which could be useful for better understanding the roles of FGF21 in myogenesis.
We will clarify the positive and negative signaling mechanisms which control the stress-related expression of FGF21 through the ISR pathway. Moreover, we will examine the role of FGF21 as an interorgan coordinator of survival functions in metabolic and stress disorders. We conclude that FGF21 can be viewed as a cell non-autonomous enhancer of longevity in mammals.
under nutrient-limiting conditions that stimulate ATF4 (show ATF4 Proteins) activity, TRIB3 (show TRIB3 Proteins) is implicated in the regulation of metabolic adaptation by restraining the transcription of Fgf21.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21