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Mouse (Murine) FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN4989626
Ji, Zheng, Lv, Xu, Ji, Luo, Li, Zhao, Yan: Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1α pathway. in Free radical biology & medicine 2015
Mouse (Murine) FGF21 Protein expressed in Human Cells - ABIN2007779
Arner, Pettersson, Mitchell, Dunbar, Kharitonenkov, Rydén: FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. in FEBS letters 2008
Show all 3 Pubmed References
Mouse (Murine) FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN1888798
Stone, Wanders, Orgeron, Cortez, Gettys: Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. in Diabetes 2014
Levels of circulating FGF-21 in overweight and obese African males are higher in type 2 diabetes mellitus and strongly correlate with measures of adiposity.
FGF-21 levels were increased significantly in acromegaly group. Increased FGF-21 levels were significantly and independently associated with the state of acromegaly.
Aerobic and resistance exercise training significantly decreased serum fetuin-A, and fetuin-B, and increased FGF-21 levels in males with type 2 diabetes mellitus.
Baseline FGF21 levels were not associated with the development of AF in an ethnically diverse population followed long-term.
In urothelial carcinoma patients, serum FGF19 level was significantly lower, while FGF21 and FGF23 were significantly higher, than respective levels in healthy controls.
there were no correlations between serum FGF21 levels and the presence of stable angina pectoris (OR: 1.248; 95% CI: 0.703-2.215; P=0.448). The present study indicates that FGF21 has a strong correlation and precise predictability for increased risks of unstable angina pectoris , that is independent of traditional risk factors of angina pectoris.
elevated serum FGF21 and FGF23 levels may be useful biomarkers for predicting kidney disease progression, especially in the early stages of Diabetic nephropathy
Serum FGF21 levels correlated with carotid intima media thickness and predict subclinical atherosclerosis.
FGF21 increases throughout pregnancy in our healthy cohort with overweight and obesity, independent of the placenta, and does not appear to be sensing the changes in energy balance (reflected in the change in maternal energy stores), but changes in macronutrient status.
FGF21 significantly predicts the incidence of coronary artery disease, the risks of metabolic syndrome, diabetes mellitus and renal progression in diabetes. It also predicted all-cause and cardiovascular mortality.
FGF21 and CK18 might play differential roles and have complementary value in non-invasive identification and monitoring the outcome of nonalcoholic fatty liver disease patients.
The association between increased basal and stimulated FGF21 levels with poor metabolic health was no longer present after weight loss. Fructose ingestion in obese humans stimulates FGF21 secretion, and this response is related to systemic metabolism.
FGF21 may defend against hepatic nutrient overload by promoting adaptations that reduce ectopic lipid storage, including inhibiting sugar and alcohol appetite and promoting lipid sequestration in adipose tissue. [Review]
Acute or binge ethanol consumption significantly increases circulating FGF21 levels in both humans and mice. FGF21 does not play a role in acute ethanol clearance. Chronic ethanol consumption in the absence of FGF21 is associated with liver pathology alone or in combination with excess mortality, depending on the type of diet consumed with ethanol. This suggests that FGF21 protects against long term ethanol damage.
analysis of FGF-21 levels in coronary artery disease and peripheral artery disease reveals that low FGF-21 is a risk factor for peripheral arterial disease
possible role of hepatokine FGF21 in the etiopathogenesis of gestational diabetes mellitus
The fibroblast growth factor -21 protein was significantly less expressed in liposarcoma than in normal tissue (p<0.05). Fibroblast growth factor -21 protein expression was related to gender, but not age, cell differentiation or tumor size. The patients in the low/no fibroblast growth factor 21 expression group were more likely to relapse and die in a shorter period of time.
These findings suggested that the serum FGF21 levels could be involved in a complex adaptive response to insulin secretion and glucose metabolism in humans.
Taking together from both physiological and genetic levels, we suggest that FGF21 is inversely associated with regional bone density.
besides the NF-kappaB pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway.
The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
FGF21, assisted by elevated glucose, activates PVN NUCB2/Nesf-1 neurons to suppress feeding under fed states, serving as the glycemia-monitoring messenger of liver-hypothalamic network for integrative regulation of energy and glucose metabolism.
With consumption of HFHS diet, FGF21 deficient mice (FGF21 KO) develop excess fatty liver within 16 weeks. Hepatic pathology progresses and at 52 weeks FGF21 KO mice show significantly worse fibrosis and 78% of mice develop HCC; in contrast only 6% of WT mice develop HCC.
SIRT1 promotes FGF21 signalling in oxytocin neurons and stimulates Oxt transcription through NRF2.
FGF21 liver-specific deficiency abolished E2-induced white adipose browning in mice with ovariectomies. This study indicates that ovarian E2 increased liver FGF21 expression directly, which in turn, functioned as an endocrine signal to influence inguinal white adipose tissue browning.
Hepatic overexpression of DEPP in mice promotes fatty acid oxidation and ketogenesis and suppresses lipogenesis and gluconeogenesis, which is partly mediated by FGF21 induced by elevated cellular ROS levels.
CReP deletion activates a linear signaling pathway involving eIF2alpha phosphorylation, ATF4 translation, and FGF21 induction, which promotes increased energy expenditure, and subsequently improved obesity-related metabolic parameters.
these data support a model in which LP-induced FGF21 drives UCP1-dependent increases energy expenditure to influence metabolic but not thermogenic endpoints.
these results indicate that FGF21 is induced during cisplatin nephrotoxicity to protect renal tubules, and recombinant FGF21 may have therapeutic potential.
CO-stimulated PERK activation and enhanced the levels of FGF21 via the eIF2alpha-ATF4 signaling pathway. The induction of FGF21 by CO attenuated endoreticulum stress- or diet-induced, obesity-dependent hepatic steatosis.
FGF21 alleviated atherosclerosis by ameliorating Fas-mediated apoptosis in apoE-/- mice.
results demonstrate that fibroblast growth factor 21 reduces the increased expression of a subset of genes in the liver in response to endoplasmic reticulum stress
Lack of FGF21 enhances the susceptibility to the development of obesity-related cardiomyopathy.
The acute increase in circulating FGF21 following fructose gavage was absent in ChREBP knockout mice. Induction of ChREBP-beta and its glycolytic, fructolytic, and lipogenic gene targets were attenuated in FGF21 knockout mice fed high-fructose diets.
Data, including data from studies using knockout mice, suggest that control of whole-body energy expenditure by Gcgr agonism requires intact Fxr signaling and Fgf21 secretion in liver. (Gcgr = glucagon receptor glucagon; Fxr = farnesoid X receptor; Fgf21 = fibroblast growth factor-21)
FGF-21 has anti-inflammatory effects in Type 2 diabetes mellitus
These data suggest that Fgf21 acts as one of intrathymic cytokines in the neonatal and juvenile thymus, involving thymocyte development in a beta-Klotho-independent manner.
During pregnancy, both systemic and cardiac-produced Fgf21 act on the heart, leading to the normal physiological cardiac changes that are associated with pregnancy.
our results demonstrated that FGF21 promotes cell cycle exit and enhances myogenic differentiation of C2C12 cells. This study provided new evidence that FGF21 promotes myogenic differentiation, which could be useful for better understanding the roles of FGF21 in myogenesis.
We will clarify the positive and negative signaling mechanisms which control the stress-related expression of FGF21 through the ISR pathway. Moreover, we will examine the role of FGF21 as an interorgan coordinator of survival functions in metabolic and stress disorders. We conclude that FGF21 can be viewed as a cell non-autonomous enhancer of longevity in mammals.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21