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Human FGF7 Protein expressed in Human - ABIN2452199
Aaronson, Bottaro, Miki, Ron, Finch, Fleming, Ahn, Taylor, Rubin: Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. in Annals of the New York Academy of Sciences 1992
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Human FGF7 Protein expressed in Escherichia coli (E. coli) - ABIN2452198
Rubin, Osada, Finch, Taylor, Rudikoff, Aaronson: Purification and characterization of a newly identified growth factor specific for epithelial cells. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Low KGF expression is associated with epithelial ovarian cancer cell proliferation and invasion.
Findings suggest that excessive KGF and KGFR synthesis may contribute to the hyperproliferative state in cholesteatoma and could explain the pathological difference between cholesteatoma and CSOM.
Results suggest that fibroblast growth factor 7 may stimulate endometrial stromal cells proliferation and insulin-like growth factor-binding protein 1 and prolactin expressions through ERK and JNK signal pathways in an autocrine manner.
The stability and activity of rhKGF mutants were analyzed using GROMACS molecular dynamics (MD) simulations and docking tools, respectively. The results showed that N159S (N105S in rhKGF sequence) and I172V (I118V in rhKGF) substitutions caused an increased stability and affinity of the rhKGF to Fibroblast growth factor receptor 2 (FGFR2).
Tregs isolated from human lung tissue can be stimulated ex vivo to induce kgf expression.
FGF7 stimulation of cell invasion and migration was partially suppressed by the FGFR2 knockdown. In addition, FGF7/FGFR2 upregulated THBS1, and cell invasion and migration were decreased by knockdown of THBS1
Suppression of miR-219-5p may benefit the liver regeneration and prevent cirrhosis through increasing KGF.
This study evaluated the expression of FGF7, AhR, and CYP1A1 in colorectal cancer cells and revealed a new mechanism by which KGF promotes cell proliferation through the AhR-cyclin D1 pathway in colon cancer cells.
KGF expression induced epithelial cell proliferation, reaching a peak level at day 4 and then decreased later, while in the long-term model, KGF expression in the EAC led to middle ear cholesteatoma formation
In the current study, conditioned media and chemically defined media with recombinant human keratinocyte growth factor (KGF) could induce hUC-MSC differentiation into sweat gland-like cells (SGCs).
Coexpression of KGF and MMP-9 in gastric cancer could be a useful prognostic factor, and MMP-9 might also serve as a novel target for both prognostic prediction and therapeutics.
FGF7 over expression is associated with advanced clinical features in patients with upper tract and bladder urothelial carcinoma
Data indicate the key roles played, on the melanosome transfer in normal skin, by KGF/FGF7 released by dermal fibroblasts and by its receptor KGFR/FGFR2b expressed and activated on the epidermal keratinocytes.
First evidence of a role of FGF7 in the regulation of sequential steps of the autophagic process and strengthen the hypothesis of a direct interplay between autophagy and differentiation.
An SNP in FGF7 is associated with an increased risk of chronic obstructive pulmonary disease.
These findings indicate that topically delivered KGF-1 DNA plasmid can increase epithelial thickness and strength, demonstrating the potential of this approach to restore compromised skin.
Recombinant keratinocyte growth factor 1 in tobacco potentially promotes wound healing in diabetic rats.
precursor of the hormone Irisin (FNCD5) were abundantly expressed in all three fat depots, along with fibroblast growth factors (FGF) FGF1, FGF7 and FGF10, whereas, FGF19 and FGF21 were undetectable.
Sustained effect of KGF on cell survival and proliferation could be attributed to its ability to inhibit p53, retinoblastoma, caspases, and p27(kip) functions in apoptosis and cell cycle arrest.
FGF7 stimulates osteogenic differentiation, but not proliferation, in embryonic stem cells, by activating ERK/Runx2 signaling.
Tregs express kgf. Treg-specific expression of kgf regulates alveolar epithelial proliferation during the resolution phase of acute lung injury and in a model of regenerative alveologenesis in vivo. AT2 cells cocultured with Tregs lacking kgf have decreased rates of proliferation.
A role for endogenous KGF in maintenance of normal pulmonary innate immune function.
BMP4 promotes activation of FGF7 and FGF10 signaling, leading to an increase in proliferative basal cell population in developing skin.
we examine how the two presynaptic organizers FGF22 and FGF7 are transported to the appropriate locations so that they act as synapse-type-specific organizing molecules.
Exendin-4 increased fibroblast growth factor 7 (Fgf7) expression in colonic polyps of Apc(Min/+) mice.
Our observations also point towards PI3K acting as a morphogenic switch for FGF7 signalling.
Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments.
IL-19 is important for cutaneous wound healing because it upregulates KGF expression.
FGF7 is downregulated in MED1-deficient mesenchymal cells. FGF7 produced by mesenchymal stromal cells is a novel hematopoietic niche molecule.
KGF pretreatment could improve radiation-induced intestinal injury including the epithelial structure and function in a mouse model, as shown by Zo-1 protein and Claudin-1.
KGF could up-regulate IL-7 expression through the STAT1/IRF-1, IRF-2 signaling pathway, which is a new insight in potential effects of KGF on the intestinal mucosal immune system.
Fibroblast growth factor 7 (Fgf7) was identified as a target of miR-143 in murine adipogenesis.
FGF7 is a critical regulator of liver progenitor cells
these data suggest that FGF7 is a novel regulator of CYP7A1 expression in hepatocytes and may prevent hepatocytes from accumulating toxic bile acids during liver injury and fibrosis.
Given the specifically targeted effects of FGF-7 on epithelial cells, the authors' findings suggest that further FGF-7-dependent epithelial-mesenchymal interaction exists that may be important in diabetic wound healing.
Keratinocyte growth factor gene transduction ameliorates pulmonary fibrosis induced by bleomycin in mice
These results suggest that KGF may play an important role in the regulation of VEGF gene expression and angiogenesis during wound healing.
KGF promotes preadipocyte proliferation by an autocrine mechanism that involves activation of the PI3K/Akt signaling pathway
two members of the fibroblast growth factor (FGF) family, FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers
Subset of KGF-expressing respiratory epithelial cells may participate in a hitherto undescribed autocrine loop for stimulating KGF production in response to injury.
analysis of regulation of endometrial fibroblast growth factor 7 (FGF-7) and its receptor FGFR2IIIb
This study investigates the relationships between progesterone, estradiol, and their receptors and the expression of FGF7 in the pig uterus in vivo.
FGF1 and FGF7 may be involved differently in the process of follicle maturation and CL formation, which is strongly dependent on angiogenesis
FGF7 may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG signaling pathway.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
, heparin-binding growth factor 7
, keratinocyte growth factor
, Keratinocyte growth factor
, fibroblast growth factor 7 (keratinocyte growth factor)
, fibroblast growth factor-7
, Putative keratinocyte growth factor-like protein 2
, fibroblast growth factor 7 L homeolog