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Study results revealed that microRNA-320a suppresses tumor cell growth and invasion of human breast cancer by targeting IGF-1R.
miR539 may inhibit the aggressive behaviour of PDAC by directly targeting IGF1R and may serve as a novel therapeutic target for patients with this disease
Data suggest that NEAT1, SRC3 (show NCOA3 Proteins), and IGF1R are highly expressed in prostate cancer cells; NEAT1 appears to interact with SRC3 (show NCOA3 Proteins) and promote cell proliferation via up-regulation of SRC3 (show NCOA3 Proteins)/IGF1R/AKT (show AKT1 Proteins) signaling pathway. (NEAT1 = nuclear paraspeckle assembly transcript-1; SRC3 (show NCOA3 Proteins) = steroid receptor coactivator protein-3 (show NCOA3 Proteins); IGF1R = insulin-like growth factor 1 receptor)
Results showed that the expression of IGF1R appears to be highly correlated with the expression of ABCG2 in osteosarcoma and with the expression of CD44 (show CD44 Proteins) in osteosarcoma patients under age of 10.
Here the authors report a nodal role of IGF-IR in the regulation of ERalpha (show ESR1 Proteins)-positive breast cancer cell aggressiveness and the regulation of expression levels of several extracellular matrix molecules.
Long noncoding RNA PVT1 enhances the expression of IGF1R through competitive binding to miR (show MLXIP Proteins)-30a.
They retained the main IGF-1R-related properties, but the hormones with His49 in IGF-1 and His48 in IGF-2 showed significantly higher affinities for IR-A and for IR-B, being the strongest IGF-1- and IGF-2-like binders of these receptors ever reported.
The association between the growth hormone (show GH1 Proteins)-insulin-like growth factor-1 (show IGF1 Proteins) (GH-IGF-1 (show IGF1 Proteins)) axis gene polymorphisms and short stature in Chinese children.
High IGF1R expression is associated with non-small cell lung cancer.
Our findings suggest that CKS1BP7 as well as IGF1R may serve as potential biomarkers for early detection and predict prognosis in breast cancer.
A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.
study determined IGFR1 and PAPP-A (show PAPPA Proteins) expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB Proteins)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A (show PAPPA Proteins) secretion as a modulator of IGF1 (show IGF1 Proteins) in cattle with COD (show SNRPB Proteins)
Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.
two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle
insulin (show INS Proteins)-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
Data describes the long-term changes to skeletal muscle growth and IGF1 (show IGF1 Proteins), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Results do not support the premise that increased apoptosis associated with high levels of IGF1 (show IGF1 Proteins) is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.
IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR (show FRAP1 Proteins) activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.
IGF-1 (show IGF1 Proteins) and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.
IGF-I (show IGF1 Proteins), IGF-II, and IGFBP-3 (show IGFBP3 Proteins) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
IL-1beta (show IL1B Proteins) impaired the actions of IGF-I (show IGF1 Proteins) at a point distal to the IGF receptor
IGF-1R is expressed in porcine somatostatin (show SST Proteins)-containing islet D-cells
This study suggests an association between the affinity of insulin (show INS Proteins) receptors and number of IGF-1 (show IGF1 Proteins) receptors with placental and/or fetal growth.
mRNA expression of IGF-I receptor
These results suggested that appropriate WBV may delay the progression of AS, which was associated with acutely elevated serum IGF-1 (show IGF1 Proteins) and lower levels of IGF-1 (show IGF1 Proteins) and IL-6 (show IL6 Proteins) in the aorta for long-term treatment.
Study showed the significance of TLR4 (show TLR4 Proteins) in upregulation of MAPK/ErK (show MAPK1 Proteins) in NMDAR (show GRIN1 Proteins) hypofunction schizophrenic-mouse model. This is characterized by a decrease in hippocampal IGF-1R/CaMKIIalpha, and social interaction behavioral deficits. Ultimately, hippocampal TLR4 (show TLR4 Proteins) knockdown rescued IGF-1R/CaMKIIalpha decline and prevented behavioral deficits by reducing MAPK/ErK (show MAPK1 Proteins) expression.
Expression of IGF-1 and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model.
diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin (show INS Proteins)/InsR (show INSR Proteins) and IGF-1 (show IGF1 Proteins)/IGF-1R signaling. Insulin (show INS Proteins) therapy in the early stage may delay diabetic gastroparesis
Data identify central IGF-1R as a mediator of the integration of nutrient and temperature homeostasis. They also show that calorie restriction, IGF-1R signaling, and body temperature, three of the main regulators of metabolism, aging, and longevity, are components of the same pathway.
RIP3 and phosphorylated MLKL expressions were relatively decreased in the IGF-1 (show IGF1 Proteins) receptor monoclonal antibody group compared to the non-treated group. IGF-1 (show IGF1 Proteins) may be associated with RIP3-mediated necroptosis in vitro, while blocking of the IGF-1 (show IGF1 Proteins) pathway may reduce LPS (show TLR4 Proteins)-induced lung injuries in vivo.
Data (including data from studies in knockout mice) suggest double knockout (DKO) mice lacking Insr (show INSR Proteins) and Igf1r exhibit obesity with insulin (show INS Proteins) resistance and increased adiposity; on high-fat diet, DKO mice exhibit metabolic syndrome. (Insr (show INSR Proteins) = insulin receptor (show INSR Proteins); Igf1r = insulin-like growth factor I receptor)
results demonstrate for the first time that Igf1r is important in acute asthma pathobiology and resolution of HDM (show HDAC3 Proteins)-induced inflammation
This study found that expressions of Cav3.2 (show CACNA1H Proteins) and IGF-1R, and their colocalization were not increased in DRGs of mice following axotomy. In addition, Cav3.2 (show CACNA1H Proteins) or IGF-1R subpopulation neurons did not acquire significant switch in expression phenotype after sciatic nerve axotomy.
The present observations indicate that IGF-IR regulates glucose transporter 1 (show SLC2A1 Proteins) activity in astrocytes.
This study evaluated the expression of IGF-1 (show IGF1 Proteins) receptor, insulin receptor (show INSR Proteins) AND IGF-1 (show IGF1 Proteins) in the lammelar tissue of horses with insulin (show INS Proteins)-induced hyperinsulinemia.
The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.
Somatomedin (IGF-I (show IGF1 Proteins)) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]
Data suggest that transgenic zebrafish that are dominant-negative for IGF1R exhibit insulin (show INS Proteins) resistant skeletal muscles and altered numbers of insulin (show INS Proteins)-secreting cells; glucose intolerance develops with age after overfeeding.
results provide novel insight into the cellular function of IGF1 (show IGF1 Proteins) receptor and show IGF1R signaling does not function as an anteriorizing signal but regulates embryonic growth and development by promoting cell survival and cell cycle progression
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
, insulin-like growth factor I receptor
, soluble IGF1R variant 1
, soluble IGF1R variant 2
, insulin-like growth factor receptor tyrosine kinase
, insulin-like growth factor-I receptor
, type 1 IGF receptor
, tyrosine kinase
, IGF-1 receptor
, insulin-like growth factor 1 receptor beta subunit
, insulin-like growth factor receptor 1
, insulin-like growth factor-1 receptor
, receptor tyrosine kinase
, insulin-like growth factor 1 receptor
, line 186
, insulin-like growth factor-1 receptor beta subunit