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IGF2 gene overexpression in a series of children diagnosed with adrenocortical tumors was not related to any clinical or biological features analyzed here, while IGF1R gene expression was significantly higher in children who presented tumor relapse and metastasis, which was not true for the IGF1R protein expression analyzed by immunohistochemistry. IGF1R overexpression could be indicative of aggressive ACTs in children.
Results show a significant over-expression of EGFR and IGF1R in adrenocortical carcinoma (ACC) tissue.
Data show that single-nucleotide polymorphisms (SNPs) of the IGF1R (rs12423791), and IGF1 (show IGF1 Proteins) (rs2162679, rs5742612, rs35767) genes were significantly associated with tumor response to oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX).
Amla extract (Emblica officinalis, AE) decreases the gene and protein expression of IGF1R, a target of miR (show MLXIP Proteins)-375, and SNAIL1 (show SNAI1 Proteins), a transcription factor that represses E-cadherin (show CDH1 Proteins) expression.
GSK1904529A, a Potent IGF-IR Inhibitor, Reverses MRP1 (show MDM4 Proteins)-Mediated Multidrug Resistance
There is an accelerated loss of IGF1R, following loss of UBQLN1 (show UBQLN1 Proteins) in lung adenocarcinoma cells.
data show that the GSK3B-FOXO3 (show FOXO3 Proteins) pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R after partial hepatectomy.
selective impairment of IGF-1 (show IGF1 Proteins)-induced DNA synthesis in lymphocytes of CDG patients through decreased gene expression and hypoglycosylation of the IGF-1 (show IGF1 Proteins) receptor
The INSR (show INSR Proteins) purified in n-dodecyl-beta-D-maltoside showed ligand-stimulated autophosphorylation and kinase activity, suggesting an intact transmembrane signaling mechanism.
Our findings suggest a novel mechanism by which CCE procyanidins can promote proteasome-independent degradation of nuclear Nrf2 (show GABPA Proteins) through IGF-1R phosphorylation and cysteine protease (show CTSB Proteins) activation.
A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.
study determined IGFR1 and PAPP-A (show PAPPA Proteins) expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB Proteins)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A (show PAPPA Proteins) secretion as a modulator of IGF1 (show IGF1 Proteins) in cattle with COD (show SNRPB Proteins)
Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.
two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle
insulin (show INS Proteins)-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
Data describes the long-term changes to skeletal muscle growth and IGF1 (show IGF1 Proteins), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Results do not support the premise that increased apoptosis associated with high levels of IGF1 (show IGF1 Proteins) is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.
IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR (show FRAP1 Proteins) activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.
IGF-1 (show IGF1 Proteins) and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.
IGF-I (show IGF1 Proteins), IGF-II, and IGFBP-3 (show IGFBP3 Proteins) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
IL-1beta (show IL1B Proteins) impaired the actions of IGF-I (show IGF1 Proteins) at a point distal to the IGF receptor
IGF-1R is expressed in porcine somatostatin (show SST Proteins)-containing islet D-cells
This study suggests an association between the affinity of insulin (show INS Proteins) receptors and number of IGF-1 (show IGF1 Proteins) receptors with placental and/or fetal growth.
mRNA expression of IGF-I receptor
results demonstrate for the first time that Igf1r is important in acute asthma pathobiology and resolution of HDM (show HDAC3 Proteins)-induced inflammation
This study found that expressions of Cav3.2 (show CACNA1H Proteins) and IGF-1R, and their colocalization were not increased in DRGs of mice following axotomy. In addition, Cav3.2 (show CACNA1H Proteins) or IGF-1R subpopulation neurons did not acquire significant switch in expression phenotype after sciatic nerve axotomy.
The present observations indicate that IGF-IR regulates glucose transporter 1 (show SLC2A1 Proteins) activity in astrocytes.
Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.
these data suggest that the decreased mammary gland tumor latency time caused by chronic IGF1R activation is related to modulation of tumor progression rather than increased tumor initiation.
Data show that tumors lacking PSMA had less than half the abundance of type 1 insulin-like growth factor receptor (IGF-1R), less activity in the survival pathway mediated by PI3K-AKT signaling, and more activity in the proliferative pathway mediated by MAPK-ERK1/2 signaling.
let-7g regulates autophagy in mouse granulosa cells by targeting insulin-like growth factor 1 receptor and downregulating protein kinase B (show AKT1 Proteins)/mammalian target of rapamycin (show FRAP1 Proteins) signaling
VEGF (show VEGFA Proteins) and IGF1 (show IGF1 Proteins) were critical factors for the spontaneous cardiac differentiation of BATDCs, and MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) signaling was involved in the role of VEGF (show VEGFA Proteins) and IGF1 (show IGF1 Proteins).
miR (show MLXIP Proteins)-223/IGF-IR signalling pathway is regulated in parallel in both the lung vasculature and the right ventricle under conditions of hypoxia induced pulmonary hypertension.
This study evaluated the expression of IGF-1 (show IGF1 Proteins) receptor, insulin receptor (show INSR Proteins) AND IGF-1 (show IGF1 Proteins) in the lammelar tissue of horses with insulin (show INS Proteins)-induced hyperinsulinemia.
The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.
Somatomedin (IGF-I (show IGF1 Proteins)) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
, insulin-like growth factor I receptor
, soluble IGF1R variant 1
, soluble IGF1R variant 2
, insulin-like growth factor receptor tyrosine kinase
, insulin-like growth factor-I receptor
, type 1 IGF receptor
, tyrosine kinase
, IGF-1 receptor
, insulin-like growth factor 1 receptor beta subunit
, insulin-like growth factor receptor 1
, insulin-like growth factor-1 receptor
, receptor tyrosine kinase
, insulin-like growth factor 1 receptor
, line 186
, insulin-like growth factor-1 receptor beta subunit