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Study characterises nuclear trafficking of IGF1R by intracellular amphiregulin as an important component of lung cancer biology, and demonstrates its contribution to the resistance of lung tumor cells to EGFR-tyrosine kinase inhibitor gefitinib.
Study shows that reduced insulin/insulin-like growth factor 1 signaling in astrocytes impairs their support for neurons under conditions of stress and this is associated with defects in the mitochondrial respiratory chain in astrocytes.
Study found that the expression of IGF1R was significantly increased in nonsmall cell lung cancer (NSCLC) and associated with poor prognosis. The mRNA expression of IGF1R in human NSCLC tissues was positively correlated with the level of EGFRAS1.
FER kinase is an important modulator of IGF-1R activity in cancer cells.Co-location of IGF-1R with FER in cell adhesion complexes enhances IGF-1R activity.
Studied insulin like growth factor 1 receptor (IGF1R) signaling and created cell line-specific models that show how early events in IGF1R signaling depend on the protein abundance profile of a cell.
Our cumulative findings indicate that Let-7c can inhibit the osteo/odontogenic differentiation of IGF-1-treated DPMSCs by targeting IGF-1R via the JNK/P38 MAPK signaling pathways.
IGF1R expression in circulating tumor cells is associated with improved prognosis in early breast cancer.
Insulin like growth factor-I and its receptor are upregulated in children with nonalcoholic fatty liver disease. These findings give a new hint for the potential therapeutic use of insulin like growth factor-I in pediatric nonalcoholic fatty liver disease complicated by liver fibrosis.
IGF1R expression was not associated with tumor recurrence, tumor progression, overall mortality, or cancer-specific mortality in upper tract urothelial carcinoma.
IGF-IR directly regulates the G2/M checkpoint via the PI3K/AKT pathway without influencing DSB repair
High IGF1R expression is associated with colorectal cancer.
We hypothesize that haploinsufficiency of the 15q26 genomic region distal to IGF1R gene might be related to growth disturbance; however, presence of the ring chromosome 15 itself could also be responsible for the growth delay.
MiR133a and miR133b may bind near rs1815009, and miR455 near rs2684788, within IGF1R 3'UTR.
study confirms the utility of proximity-labeling methods, such as BioID, to screen for interactors of cell-surface receptors and has uncovered a role of one of these interactors, SNX6, in the IGF1R signaling cascade.
Elevations of TGF-beta3, SMAD2 and SMAD4 in hypertrophic scars and increase of IGF-1R in immature stages may give some clues for acne hypertrophic scar formation.
miR-30a-5p could influence chemo-resistance by targeting IGF1R gene in melanoma cells, which might provide a potential target for the therapy of chemo-resistant melanoma cells.
IGF-1R signalling contributes to T cell dependent inflammation in arthritis. Inhibition of IGF-1R on the level of insulin receptor substrates alleviates arthritis by restricting IL6-dependent formation of Th17 cells and may open for new treatment strategies in rheumatoid arthritis.
Novel G310D variant in the insulin-like growth factor 1 receptor gene is associated with type 2 diabetes.
The molecular interactions of IGF1-IGF1R binding have been dissected.
higher IGF-IR mRNA expression observed in obese children, associated with the higher IGF-I and ALS and the lower IGFBP-1 levels
rs110343126 associated with fertility in hot-humid climate
A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.
study determined IGFR1 and PAPP-A expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A secretion as a modulator of IGF1 in cattle with COD
Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.
two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle
insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
Data describes the long-term changes to skeletal muscle growth and IGF1, 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Results do not support the premise that increased apoptosis associated with high levels of IGF1 is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.
IGF-I down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.
IGF-1 and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.
granulosa cell clustering is accompanied by marked increases in FSHr, IGF-1r, and p450 arom expression, and precedes induction and subsequent peak E2 production
Treatment with IGF1R antibodies reduced the stimulatory effect of IGF2 and IGF1 on estradiol production and cell proliferation.
For Day 25 conceptuses, there was higher expression of IGF-I mRNA for nuclear transfer and in vitro production embryonic tissues than for in vivo embryonic tissues.
Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
delivery of insulin-like growth factor-1 (IGF-1, delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1, its receptor (IGF-1R), and a well known IGF-1 binding protein (IGFBP-3) by articular chondrocytes
study to assess the mRNA expression of IGF-I, IGF-II, IGF-IR and IGF-IIR in bovine oocytes and different stages of preimplantation embryos
Data conclude that insulin and IGF-I receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
IGF-I, IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
IL-1beta impaired the actions of IGF-I at a point distal to the IGF receptor
IGF-1R is expressed in porcine somatostatin-containing islet D-cells
This study suggests an association between the affinity of insulin receptors and number of IGF-1 receptors with placental and/or fetal growth.
mRNA expression of IGF-I receptor
results point to a new TTR role through the IGF-I axis, mediated through TTR-IGF-IR interactions.
Astrocyte-specific knockout of IGFR impaired working memory, mitochondrial metabolism, and amyloid-beta uptake.
IGF-1R is necessary for the early orientation and polarity switch of cortical plate neurons and, therefore, for normal neuron migration and differentiation, including axonal outgrowth and the establishment of neuronal polarity.
Results suggest that insulin-like growth factor 1 receptor (IGF1R) signaling plays an important role in regulating embryonic epicardial cells (EPCs) proliferation, and this effect may be mediated by focal adhesion kinase (FAK) pathway.
Cell-lineage tracing revealed progenitor Leydig cell enrichment is secondary to Insr and Igf1r deletion in differentiated adult Leydig cell , suggesting a feedback mechanism between cells at different steps of differentiation.
we demonstrated that hypoxia significantly induced the GSC mesenchymal transition, increased the expression levels of the pluripotent transcription factor OCT4 and migration-associated proteins..he underlying mechanism involved significant IGF-1/IGF-1R activation of OCT4/CXCR4 expression through HIF-2alpha regulation.
These findings identify IGF1R as an important player in murine acute lung inflammation, suggesting that targeting IGF1R may counteract the inflammatory component of many lung diseases.
These results suggested that appropriate WBV may delay the progression of AS, which was associated with acutely elevated serum IGF-1 and lower levels of IGF-1 and IL-6 in the aorta for long-term treatment.
Study showed the significance of TLR4 in upregulation of MAPK/ErK in NMDAR hypofunction schizophrenic-mouse model. This is characterized by a decrease in hippocampal IGF-1R/CaMKIIalpha, and social interaction behavioral deficits. Ultimately, hippocampal TLR4 knockdown rescued IGF-1R/CaMKIIalpha decline and prevented behavioral deficits by reducing MAPK/ErK expression.
Expression of IGF-1 and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model.
diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin/InsR and IGF-1/IGF-1R signaling. Insulin therapy in the early stage may delay diabetic gastroparesis
Data identify central IGF-1R as a mediator of the integration of nutrient and temperature homeostasis. They also show that calorie restriction, IGF-1R signaling, and body temperature, three of the main regulators of metabolism, aging, and longevity, are components of the same pathway.
RIP3 and phosphorylated MLKL expressions were relatively decreased in the IGF-1 receptor monoclonal antibody group compared to the non-treated group. IGF-1 may be associated with RIP3-mediated necroptosis in vitro, while blocking of the IGF-1 pathway may reduce LPS-induced lung injuries in vivo.
Data (including data from studies in knockout mice) suggest double knockout (DKO) mice lacking Insr and Igf1r exhibit obesity with insulin resistance and increased adiposity; on high-fat diet, DKO mice exhibit metabolic syndrome. (Insr = insulin receptor; Igf1r = insulin-like growth factor I receptor)
results demonstrate for the first time that Igf1r is important in acute asthma pathobiology and resolution of HDM-induced inflammation
This study found that expressions of Cav3.2 and IGF-1R, and their colocalization were not increased in DRGs of mice following axotomy. In addition, Cav3.2 or IGF-1R subpopulation neurons did not acquire significant switch in expression phenotype after sciatic nerve axotomy.
The present observations indicate that IGF-IR regulates glucose transporter 1 activity in astrocytes.
Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.
This study evaluated the expression of IGF-1 receptor, insulin receptor AND IGF-1 in the lammelar tissue of horses with insulin-induced hyperinsulinemia.
The laminar cell types expressing insulin receptor and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.
Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]
Data suggest that transgenic zebrafish that are dominant-negative for IGF1R exhibit insulin resistant skeletal muscles and altered numbers of insulin-secreting cells; glucose intolerance develops with age after overfeeding.
define the first functional gene set for habituation learning in a vertebrate and identify pregnancy-associated plasma protein-aa-regulated IGF signaling
Duplicated zebrafish ig f1r genes (ig f1ra and ig f1rb)play largely overlapping but not identical functional roles in early development.
results provide novel insight into the cellular function of IGF1 receptor and show IGF1R signaling does not function as an anteriorizing signal but regulates embryonic growth and development by promoting cell survival and cell cycle progression
Data show a significant decrease in IGF-IR transcript numbers from type 1 diabetic blastocysts.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
, insulin-like growth factor I receptor
, soluble IGF1R variant 1
, soluble IGF1R variant 2
, insulin-like growth factor receptor tyrosine kinase
, insulin-like growth factor-I receptor
, type 1 IGF receptor
, tyrosine kinase
, IGF-1 receptor
, insulin-like growth factor 1 receptor beta subunit
, insulin-like growth factor receptor 1
, insulin-like growth factor-1 receptor
, receptor tyrosine kinase
, insulin-like growth factor 1 receptor
, line 186
, insulin-like growth factor-1 receptor beta subunit