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Our results suggest close conformational conservation between closed EAG (Kv12.1 and Kv10.2) and Shaker family channels, despite large differences in voltage sensitivity, activation rates, and activation threshold
Kv12.1 channels add to the growing list of K(+) channels that are insensitive to phospholipase C beta signaling
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit.
ELK channel 3
, ether-a-go-go-like potassium channel 3
, potassium voltage-gated channel subfamily H member 8
, potassium voltage-gated channel, subfamily H, member 8
, voltage-gated potassium channel subunit Kv12.1
, ether-a-go-go-like potassium channel 1
, potassium voltage-gated channel, subfamily H (eag-related), member 8