No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Mouse (Murine) MME Protein expressed in Human Cells - ABIN2007528
Oefner, DArcy, Hennig, Winkler, Dale: Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon. in Journal of molecular biology 2000
Show all 5 Pubmed References
Human MME Protein expressed in HEK-293 Cells - ABIN2181505
Pardossi-Piquard, Dunys, Yu, St George-Hyslop, Alves da Costa, Checler: Neprilysin activity and expression are controlled by nicastrin. in Journal of neurochemistry 2006
Show all 4 Pubmed References
Human MME Protein expressed in Wheat germ - ABIN1311049
Li, Tao, Bova, Liu, Chan, Zhu, Zhang: Detection and verification of glycosylation patterns of glycoproteins from clinical specimens using lectin microarrays and lectin-based immunosorbent assays. in Analytical chemistry 2011
receptor signaling and NEP are involved in the resistance of CNP to human mesangial proliferation and Col-IV expression.
Urinary ACE2, neprilysin, and ADAM17 are increased in patients with diabetes and could be used as early biomarkers to predict the incidence or progression of CKD at early stages among individuals with type 2 diabetes.
Our detailed analyses, with a substantial number of brain samples, provide the first convincing evidence that DNA methylation of the NEP promoter is not involved in Alzheimer disease development and progression.
Tumorous CD10 is more strongly related to progression of urothelial carcinoma than stromal CD10 and is an independent factor for UC prognosis
showed CD10 positivity in fibroblast-like stromal cells and fibrous material
these data indicated under cigarette smoke condensate treatment; losing of membrane p120ctn could upregulate surface NEP protein level and thus facilitate BEAS-2B cell migration.
High expression of CD10 is associated with lymph node invasion in colorectal cancer.
We observed an increase of VCAM-1 urine levels in diabetic nephropathy-basal patients compared to diabetic controls and an increase of urinary neprilysin in DN-treated patients with persistent albuminuria
Degradation of tropoelastin and skin elastin by neprilysin
Xanthorrhizol (Xan) reduced 4-hydroxynonenal (HNE) levels on NEP proteins and preserved enzymatic activities of neprilysin (NEP) in HNE- or oligomeric Abeta42-treated cells. Xan reduced Abeta42 accumulation and protected neurones against oligomeric Abeta42-induced neurotoxicity through preservation of NEP activities
These findings support the role of the stromal CD10 expression in breast cancer progression and dissemination, and suggest a relationship with cancer stem cells.
Aberrant CD10 and BCL6 expression defines a subset of MCLs with higher mean Ki-67 index and higher prevalence of MUM1 expression
In Pakistani population, the frequency of GCB type DLBCL [diffuse large B cell lymphoma ]expressing CD10 and BCL6 is 37.5%, and non- GCB type DLBCL [diffuse large B cell lymphoma ] expressing MUM1 is 62.5%.
Our study firstly confirmed the association of MME miRNA binding site polymorphism with the risk of LOAD. However, the association results warrant further validation.
the Ras signaling pathway is involved in HIV-1 Tat-induced changes in ZO-1 and NEP.
In this meta-analysis of the Han Chinese population, neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese populations.
CD10 is a necessary component conferring the L1 effects in CRC cells. The identification of gene expression patterns of L1-domain-specific point mutations may provide novel markers and targets for interfering with L1-mediated CRC progression.
High CD10 expression is associated with lymphoma in Waldeyer ring.
Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies
CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine
Following low-fat feeding, NEP(-/-) mice exhibited lower beta- and alpha-cell mass compared with wild-type controls. A high-fat diet had no effect on these parameters in wild-type mice, but in NEP(-/-) mice, it resulted in the expansion of beta-cell mass.
feeding monohydroxylated demethoxycurcumin (also named demethylcurcumin) or dihydroxylated bisdemethoxycurcumin (also named bisdemethylcurcumin) to APPswe/PS1dE9 double transgenic mice upregulated NEP levels in the brain and reduced Abeta accumulation in the hippocampus and cortex.
The abundance of elastic fibers was reduced and fragmented in obesity, suggesting that the reduction in elastic fibers is initially caused by increased neprilysin and decreased fibrillin-1 expression, which may inhibit formation and stabilization of elastic fibers, resulting in skin fragility in obesity.
results indicate that NEP accelerates adipogenesis through enhancement of insulin-mediated PI3K-Akt activation and imply a high therapeutic value of NEP in treating obesity and obesity-related disorders.
Amyloid beta (Abeta)-degrading effects of overexpressed neprilysin can block deleterious BACE1-elevating mechanisms that accelerate Abeta production
Serum CD10 levels might serve as a useful marker of synchronous and metachronous liver metastasis in colorectal cancer.
Cell hypoxia in neuroblastoma cells results in up-regulation of neprilysin expression.
Neprilysin knockout mice developed more severe hyperalgesia than wild-type mice.
Data indicate that 5-aza-deoxycytidine induced the demethylation of neprilysin (NEP) gene and significantly increased NEP expression in a dose-dependent manner.
Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP/guanylyl cyclase B in the epididymal epithelium.
exogenous neprilysin was localized mainly in endosomes, thereby effectively excluding Abeta oligomers from the brain. AAV vector-mediated gene transfer may provide a therapeutic strategy for neurodegenerative diseases
These data suggest that NEP plays an important role in regulating the hair cycle by its increased expression and activity in the follicular epithelium during early anagen.
Data suggest that neprilysin (NEP) is up-regulated with chronic exposure of islet beta cells to free fatty acid and leads to insulin secretory dysfunction; in knockout mice, lack of NEP protects against high-fat induced insulin secretory dysfunction.
Genetic deficiency in neprilysin in conjunction with physiological stress initiate excessive alcohol consumption in mice.
Cell surface expression of the major amyloid-beta peptide (Abeta)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.
hypoxia may down-regulate NEP by increasing H3K9me2 and decreasing H3-Ace modulation
In this study, neutral endopeptidase played a role in regulating nerve function in insulin-deficient diabetes and obesity.
in vivo findings suggest that loss of NEP in mice could cause increased susceptibility to injury or exacerbate inflammatory responses after diesel exhaust particles exposure via release of specific cytokines from the lungs
NEP is a crucial player in the development of obesity.
Neutral endopeptidase 24.11 and DPP-IV is superior to DPP-IV inhibition alone in preserving intact GLP-1, which implies possibility that the combination has therapeutic potential.
This study provides evidence that NEP 24.11 is an important mediator of the degradation of both endogenous and exogenous glucagon in vivo.
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.
, common acute lymphocytic leukemia antigen
, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)
, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
, membrane metallo-endopeptidase variant 1
, membrane metallo-endopeptidase variant 2
, neutral endopeptidase 24.11
, skin fibroblast elastase
, common acute lymphoblastic leukemia antigen
, neutral endopeptidase
, neprilysin-410 short isoform
, membrane metallo endopeptidase
, membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase)
, LOW QUALITY PROTEIN: neprilysin