Browse our anti-NFAT1 (NFAT1) Antibodies

Full name:: anti-Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Antibodies (NFAT1)

On www.antibodies-online.com are 164 Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) Antibodies from 24 different suppliers available. Additionally we are shipping NFAT1 Kits (8) and NFAT1 Proteins (8) and many more products for this protein. A total of 186 NFAT1 products are currently listed.

Synonyms:: AI607462, NF-ATc2, NFAT1, NFAT1-D, NFATC2, NFATP

list all antibodies	Gene Name	GeneID	UniProt
	NFAT1	18019	Q60591
	NFAT1	4773	Q13469
	NFAT1	311658
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Most Popular Reactivities for anti-NFAT1 (NFAT1) Antibodies

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anti-Mouse (Murine) NFAT1 Antibodies:

anti-Human NFAT1 Antibodies:

anti-Rat (Rattus) NFAT1 Antibodies:

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Top referenced anti-NFAT1 Antibodies

Human Monoclonal NFAT1 Primary Antibody for ChIP, ELISA - ABIN152663 : Bonnet, Rochefort, Sutendra, Archer, Haromy, Webster, Hashimoto, Bonnet, Michelakis: The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
Show all 9 Pubmed References
Cow (Bovine) Polyclonal NFAT1 Primary Antibody for WB - ABIN2779960 : Glud, Sørensen, Andrulis, Wang, Kondo, Jessen, Krenacs, Stelkovics, Wabl, Serfling, Palmetshofer, Pedersen: A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. in Blood 2005 (PubMed)
Show all 3 Pubmed References
Human Polyclonal NFAT1 Primary Antibody for IHC, IHC (p) - ABIN4339296 : Quang, Leboucher, Passaro, Fuhrmann, Nourieh, Vincent-Salomon, Ghysdael: The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells. in Cell death & disease 2015 (PubMed)
Show all 2 Pubmed References
Human Polyclonal NFAT1 Primary Antibody for ELISA, IHC - ABIN4339294 : Celil Aydemir, Lee, Won Kim, Gardner, Prince, Mok Ahn, Lee, Young-In Lee: Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction. in Annals of the New York Academy of Sciences 2007 (PubMed)
Human Polyclonal NFAT1 Primary Antibody for ICC, IF - ABIN4339295 : Perotti, Baldassari, Molla, Vegetti, Bersani, Maurichi, Santinami, Anichini, Mortarini: NFATc2 is an intrinsic regulator of melanoma dedifferentiation. in Oncogene 2016 (PubMed)

More Antibodies against NFAT1 Interaction Partners

Mouse (Murine) Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) interaction partners

NFATc2 isoform was the most highly expressed in murine microglia cultures, and inhibition or deletion of NFATc2 was sufficient to attenuate the ability of the microglia to secrete cytokines. AbetaPP/PS1 (show PSEN1 Antibodies) (Alzheimer's disease model) x NFATc2-/- mice had attenuated cytokine levels compared to AbetaPP/PS1 (show PSEN1 Antibodies) mice as well as reduced microgliosis and astrogliosis with no effect on plaque load.
data suggest that NFAT1 may limit the hyperactivation of the NF-kappaB (show NFKB1 Antibodies)-mediated proinflammatory response in DCs and suppress autoimmunity by serving as a key regulator of DC tolerance.
These results support the idea that NFAT1 is necessary to fully suppress effector responses during Plasmodium-induced CD4 (show CD4 Antibodies)(+) T cell exhaustion.
These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (show CCNE1 Antibodies) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.
Overexpression of either ca-Nfatc2 or ca-Nfatc1 (show NFATC1 Antibodies) in mouse islets enhanced insulin (show INS Antibodies) secretion, whereas only ca-Nfatc2 was able to promote b-cell proliferation, suggesting distinct molecular pathways mediating insulin (show INS Antibodies) secretion vs. b-cell proliferation are regulated by NFAT (show NFATC1 Antibodies)
our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4 (show CD4 Antibodies)(+)/CD8 (show CD8A Antibodies)(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation.
It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Antibodies)-mediated maintenance of whole body homeostasis
NFAT (show NFATC1 Antibodies) directs signaling enzymes to gene promoters in islets.
FOXP3 (show FOXP3 Antibodies) can inhibit NFAT (show NFATC1 Antibodies) driven expression of CD40L (show CD40LG Antibodies) and IL-17 (show IL17A Antibodies) in CD4 (show CD4 Antibodies) T cells through its interaction with NFAT1 and inhibition of this interaction by a short synthetic peptide can modulate effector T cell activity
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.

Human Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) interaction partners

Results show that NFAT1 expression is regulated by ASIC2 (show ACCN1 Antibodies) under acidosis and that NFAT1, binds to genes clustered in pathways involved in Rho GTPase (show RACGAP1 Antibodies) signaling and calcium signaling.
Our results indicate that NFATc2 may be used as an early diagnostic or predictive biomarker for colorectal carcinoma as well as a therapeutic target
NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2 (show SOX2 Antibodies)/ ALDH1A1 (show ALDH1A1 Antibodies) axis in lung adenocarcinoma.
NFATc2 and Sp1 (show PSG1 Antibodies) are co-localized in cell nuclei and physically interact at the NFAT (show NFATC1 Antibodies) target sequence termed NFAT (show NFATC1 Antibodies)-responsive promotor construct. Sp1 (show PSG1 Antibodies) increases the functional activity of its binding partner NFATc2.
Our data have shown for the first time the regulation of CacyBP/SIP (show CACYBP Antibodies) gene expression by NFAT1. Since NFAT (show NFATC1 Antibodies) transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP (show CACYBP Antibodies) in the immune system.
An interaction of NFAT1 and the beta-catenin (show CTNNB1 Antibodies) pathway, validate lysophosphatidic acid as an in vivo activator of beta-catenin (show CTNNB1 Antibodies)-dependent transcription during allograft fibrogenesis.
the expression of NFATc2 promotes melanoma dedifferentiation and immune escape
NFAT1 is stimulated by subplasmalemmal Ca2 (show CA2 Antibodies)+ microdomains, whereas NFAT4 (show NFATC3 Antibodies) additionally requires Ca2 (show CA2 Antibodies)+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors.
NFAT1 overexpression is associated with Melanoma Tumor Growth and Metastasis.
These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (show CCNE1 Antibodies) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.

NFAT1 Antigen Profile

Antigen Summary

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.

Alternative names and synonyms associated with NFAT1

nuclear factor of activated T-cells 2 (NFATC2) antibody
nuclear factor of activated T-cells 2 (nfatc2) antibody
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 (Nfatc2) antibody
nuclear factor of activated T-cells 2 (Nfatc2) antibody

AI607462 antibody
NF-ATc2 antibody
NFAT1 antibody
NFAT1-D antibody
NFATC2 antibody
NFATP antibody

Protein level used designations for NFAT1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 , nuclear factor of activated T-cells, cytoplasmic 2-like , NF-ATp , NFAT pre-existing subunit , T-cell transcription factor NFAT1 , nuclear factor of activated T-cells, cytoplasmic 2 , NF-ATc2 , NFAT transcription complex, preexisting component , T cell transcription factor NFAT1 , nuclear factor of activated T-cells, preexisting component , preexisting nuclear factor of activated T-cells 2

GENE ID	SPECIES
100052657	Equus caballus
469972	Pan troglodytes
100450332	Pongo abelii
100464798	Ailuropoda melanoleuca
100542144	Meleagris gallopavo
100556205	Anolis carolinensis
100599959	Nomascus leucogenys
710601	Macaca mulatta
100414856	Callithrix jacchus
100490186	Xenopus (Silurana) tropicalis
18019	Mus musculus
4773	Homo sapiens
311658	Rattus norvegicus
485930	Canis lupus familiaris
100134969	Sus scrofa
530401	Bos taurus
419346	Gallus gallus

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Show all anti-Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) Antibodies with Pubmed References

Mouse (Murine) Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) interaction partners

Human Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) interaction partners

Antigen Summary

Alternative names and synonyms associated with NFAT1

Protein level used designations for NFAT1