Browse our anti-NFAT1 (NFAT1) Antibodies

Mouse (Murine) Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) interaction partners

1. NFATc2 isoform was the most highly expressed in murine microglia cultures, and inhibition or deletion of NFATc2 was sufficient to attenuate the ability of the microglia to secrete cytokines. AbetaPP/PS1 (show PSEN1 Antibodies) (Alzheimer's disease model) x NFATc2-/- mice had attenuated cytokine levels compared to AbetaPP/PS1 (show PSEN1 Antibodies) mice as well as reduced microgliosis and astrogliosis with no effect on plaque load.

2. data suggest that NFAT1 may limit the hyperactivation of the NF-kappaB (show NFKB1 Antibodies)-mediated proinflammatory response in DCs and suppress autoimmunity by serving as a key regulator of DC tolerance.

3. These results support the idea that NFAT1 is necessary to fully suppress effector responses during Plasmodium-induced CD4 (show CD4 Antibodies)(+) T cell exhaustion.

4. These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (show CCNE1 Antibodies) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.

5. Overexpression of either ca-Nfatc2 or ca-Nfatc1 (show NFATC1 Antibodies) in mouse islets enhanced insulin (show INS Antibodies) secretion, whereas only ca-Nfatc2 was able to promote b-cell proliferation, suggesting distinct molecular pathways mediating insulin (show INS Antibodies) secretion vs. b-cell proliferation are regulated by NFAT (show NFATC1 Antibodies)

6. our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4 (show CD4 Antibodies)(+)/CD8 (show CD8A Antibodies)(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation.

7. It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Antibodies)-mediated maintenance of whole body homeostasis

8. NFAT (show NFATC1 Antibodies) directs signaling enzymes to gene promoters in islets.

9. FOXP3 (show FOXP3 Antibodies) can inhibit NFAT (show NFATC1 Antibodies) driven expression of CD40L (show CD40LG Antibodies) and IL-17 (show IL17A Antibodies) in CD4 (show CD4 Antibodies) T cells through its interaction with NFAT1 and inhibition of this interaction by a short synthetic peptide can modulate effector T cell activity

10. Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.

Human Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) interaction partners

1. NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2 (show SOX2 Antibodies)/ ALDH1A1 (show ALDH1A1 Antibodies) axis in lung adenocarcinoma.

2. NFATc2 and Sp1 (show PSG1 Antibodies) are co-localized in cell nuclei and physically interact at the NFAT (show NFATC1 Antibodies) target sequence termed NFAT (show NFATC1 Antibodies)-responsive promotor construct. Sp1 (show PSG1 Antibodies) increases the functional activity of its binding partner NFATc2.

3. Our data have shown for the first time the regulation of CacyBP/SIP (show CACYBP Antibodies) gene expression by NFAT1. Since NFAT (show NFATC1 Antibodies) transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP (show CACYBP Antibodies) in the immune system.

4. An interaction of NFAT1 and the beta-catenin (show CTNNB1 Antibodies) pathway, validate lysophosphatidic acid as an in vivo activator of beta-catenin (show CTNNB1 Antibodies)-dependent transcription during allograft fibrogenesis.

5. the expression of NFATc2 promotes melanoma dedifferentiation and immune escape

6. NFAT1 is stimulated by subplasmalemmal Ca2 (show CA2 Antibodies)+ microdomains, whereas NFAT4 (show NFATC3 Antibodies) additionally requires Ca2 (show CA2 Antibodies)+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors.

7. NFAT1 overexpression is associated with Melanoma Tumor Growth and Metastasis.

8. These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (show CCNE1 Antibodies) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.

9. revealed more than 170 NFAT (show NFATC1 Antibodies)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (show NFATC1 Antibodies) and NFATc2 in T cells, such as Raptor (show RPTOR Antibodies), CHEK1 (show CHEK1 Antibodies), CREB1 (show CREB1 Antibodies), RUNX1 (show RUNX1 Antibodies), SATB1 (show SATB1 Antibodies), Ikaros (show IKZF1 Antibodies), and Helios (show ZNFN1A2 Antibodies).

10. NFAT1 silencing could suppress cell migration and invasion through MMP-3 (show MMP3 Antibodies).