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anti-Mouse (Murine) NFAT1 Antibodies:
anti-Human NFAT1 Antibodies:
anti-Rat (Rattus) NFAT1 Antibodies:
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Human Monoclonal NFAT1 Primary Antibody for ChIP, ELISA - ABIN152663
Bonnet, Rochefort, Sutendra, Archer, Haromy, Webster, Hashimoto, Bonnet, Michelakis: The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 9 Pubmed References
Cow (Bovine) Polyclonal NFAT1 Primary Antibody for WB - ABIN2779960
Glud, Sørensen, Andrulis, Wang, Kondo, Jessen, Krenacs, Stelkovics, Wabl, Serfling, Palmetshofer, Pedersen: A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. in Blood 2005
Show all 3 Pubmed References
Human Polyclonal NFAT1 Primary Antibody for IHC, IHC (p) - ABIN4339296
Quang, Leboucher, Passaro, Fuhrmann, Nourieh, Vincent-Salomon, Ghysdael: The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells. in Cell death & disease 2015
Show all 2 Pubmed References
Human Polyclonal NFAT1 Primary Antibody for ELISA, IHC - ABIN4339294
Celil Aydemir, Lee, Won Kim, Gardner, Prince, Mok Ahn, Lee, Young-In Lee: Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction. in Annals of the New York Academy of Sciences 2007
Human Polyclonal NFAT1 Primary Antibody for ICC, IF - ABIN4339295
Perotti, Baldassari, Molla, Vegetti, Bersani, Maurichi, Santinami, Anichini, Mortarini: NFATc2 is an intrinsic regulator of melanoma dedifferentiation. in Oncogene 2016
NFATc2 isoform was the most highly expressed in murine microglia cultures, and inhibition or deletion of NFATc2 was sufficient to attenuate the ability of the microglia to secrete cytokines. AbetaPP/PS1 (show PSEN1 Antibodies) (Alzheimer's disease model) x NFATc2-/- mice had attenuated cytokine levels compared to AbetaPP/PS1 (show PSEN1 Antibodies) mice as well as reduced microgliosis and astrogliosis with no effect on plaque load.
data suggest that NFAT1 may limit the hyperactivation of the NF-kappaB (show NFKB1 Antibodies)-mediated proinflammatory response in DCs and suppress autoimmunity by serving as a key regulator of DC tolerance.
These results support the idea that NFAT1 is necessary to fully suppress effector responses during Plasmodium-induced CD4 (show CD4 Antibodies)(+) T cell exhaustion.
These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (show CCNE1 Antibodies) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.
Overexpression of either ca-Nfatc2 or ca-Nfatc1 (show NFATC1 Antibodies) in mouse islets enhanced insulin (show INS Antibodies) secretion, whereas only ca-Nfatc2 was able to promote b-cell proliferation, suggesting distinct molecular pathways mediating insulin (show INS Antibodies) secretion vs. b-cell proliferation are regulated by NFAT (show NFATC1 Antibodies)
our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4 (show CD4 Antibodies)(+)/CD8 (show CD8A Antibodies)(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation.
It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Antibodies)-mediated maintenance of whole body homeostasis
NFAT (show NFATC1 Antibodies) directs signaling enzymes to gene promoters in islets.
FOXP3 (show FOXP3 Antibodies) can inhibit NFAT (show NFATC1 Antibodies) driven expression of CD40L (show CD40LG Antibodies) and IL-17 (show IL17A Antibodies) in CD4 (show CD4 Antibodies) T cells through its interaction with NFAT1 and inhibition of this interaction by a short synthetic peptide can modulate effector T cell activity
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
Results show that NFAT1 expression is regulated by ASIC2 (show ACCN1 Antibodies) under acidosis and that NFAT1, binds to genes clustered in pathways involved in Rho GTPase (show RACGAP1 Antibodies) signaling and calcium signaling.
Our results indicate that NFATc2 may be used as an early diagnostic or predictive biomarker for colorectal carcinoma as well as a therapeutic target
NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2 (show SOX2 Antibodies)/ ALDH1A1 (show ALDH1A1 Antibodies) axis in lung adenocarcinoma.
NFATc2 and Sp1 (show PSG1 Antibodies) are co-localized in cell nuclei and physically interact at the NFAT (show NFATC1 Antibodies) target sequence termed NFAT (show NFATC1 Antibodies)-responsive promotor construct. Sp1 (show PSG1 Antibodies) increases the functional activity of its binding partner NFATc2.
Our data have shown for the first time the regulation of CacyBP/SIP (show CACYBP Antibodies) gene expression by NFAT1. Since NFAT (show NFATC1 Antibodies) transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP (show CACYBP Antibodies) in the immune system.
An interaction of NFAT1 and the beta-catenin (show CTNNB1 Antibodies) pathway, validate lysophosphatidic acid as an in vivo activator of beta-catenin (show CTNNB1 Antibodies)-dependent transcription during allograft fibrogenesis.
the expression of NFATc2 promotes melanoma dedifferentiation and immune escape
NFAT1 is stimulated by subplasmalemmal Ca2 (show CA2 Antibodies)+ microdomains, whereas NFAT4 (show NFATC3 Antibodies) additionally requires Ca2 (show CA2 Antibodies)+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors.
NFAT1 overexpression is associated with Melanoma Tumor Growth and Metastasis.
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
, nuclear factor of activated T-cells, cytoplasmic 2-like
, NFAT pre-existing subunit
, T-cell transcription factor NFAT1
, nuclear factor of activated T-cells, cytoplasmic 2
, NFAT transcription complex, preexisting component
, T cell transcription factor NFAT1
, nuclear factor of activated T-cells, preexisting component
, preexisting nuclear factor of activated T-cells 2