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Human Polyclonal NTRK3 Primary Antibody for BR, CyTOF - ABIN5013014
Huang, Lai, Wu, Hsu, Cheng, Lan, Chiu: BDNF mediated TrkB activation is a survival signal for transitional cell carcinoma cells. in International journal of oncology 2010
Show all 3 Pubmed References
Human Monoclonal NTRK3 Primary Antibody for ELISA, WB - ABIN969324
Hisaoka, Sheng, Tanaka, Hashimoto: Gene expression of TrkC (NTRK3) in human soft tissue tumours. in The Journal of pathology 2002
Human Polyclonal NTRK3 Primary Antibody for FACS - ABIN4897363
Rezaee, Rellick, Piedimonte, Akers, OLeary, Martin, Craig, Gibson: Neurotrophins regulate bone marrow stromal cell IL-6 expression through the MAPK pathway. in PLoS ONE 2010
Human Monoclonal NTRK3 Primary Antibody for CyTOF, FACS - ABIN4900210
Delcroix, Curtis, Schiller, Montero-Menei: EGF and bFGF pre-treatment enhances neural specification and the response to neuronal commitment of MIAMI cells. in Differentiation; research in biological diversity 2010
Data show that neurotrophin 3 (show NTF3 Antibodies) receptor TrkC acts as an activator in tumorigenicity and metastasis of colorectal cancer, and was frequently overexpressed in colorectal cancer (CRC (show CALR Antibodies)) cells, patients' tumor samples.
LINC00052 could regulate NTRK3 expression by forming complementary base pairing with miR (show MLXIP Antibodies)-128 and miR (show MLXIP Antibodies)-485-3p to reduce the luciferase activity of NTRK3 3'UTR (show UTS2R Antibodies).
Case Reports: mammary analog secretory carcinoma of the thyroid gland with ETV6 (show ETV6 Antibodies) rearrangement and ETV6 (show ETV6 Antibodies)-NTRK3 gene fusion.
The prevalence of ETV6 (show ETV6 Antibodies)-NTRK3 kinase fusions were determined in papillary thyroid cancer of adult population
We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as Mammary analogue secretory carcinoma after next-generation sequencing revealed an ETV6-NTRK3 fusion.
Data suggest that kinase domains of neurotrophin (show BDNF Antibodies) receptor isoforms, TRKA (show NTRK1 Antibodies), TRKB (show NTRK2 Antibodies), and TRKC, exhibit a bulky phenylalanine gatekeeper, leading to a small and unattractive back pocket/binding site for antineoplastic kinase inhibitors. [REVIEW]
Pan (show SUPT6H Antibodies)-Trk (show NTRK1 Antibodies) immunohistochemistry is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma.
5 gastrointestinal stromal tumors cases lacking alterations in the KIT/PDGFRA (show PDGFRA Antibodies)/SDHx/RAS pathways, including two additional cases with FGFR1 (show FGFR1 Antibodies)-TACC1 (show TACC1 Antibodies) and ETV6 (show ETV6 Antibodies)-NTRK3 fusions, are reported.
High expression of TrkC is associated with glioblastoma.
Study found that copy number variations of NTRK3 were associated with platinum-sensitive and platinum-resistant recurrences. Amplification of NTRK3 perfectly predicted platinum-sensitive relapse of ovarian cancer.
our data suggest that Runx3 (show RUNX3 Antibodies) may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 variants
adult homozygous TrkAC knock-in mice displayed severe deficits in acute and tissue injury-induced pain, representing the first viable adult Trk (show NTRK1 Antibodies) mouse mutant with a pain phenotype
TrkC expression in E13.5 VCG neurons requires NeuroD (show NEUROD1 Antibodies) and that TrkC expression may be necessary for the normal migration and innervations of those neurons.
The dependence receptor TrkC interacts with Cobra1 (show COBRA1 Antibodies).TrkC killer fragment shuttles with Cobra1 (show COBRA1 Antibodies) to the mitochondria to engage apoptosis.
ETV6 (show ETV6 Antibodies)-SAM (show TTN Antibodies) domain interface mutations block ETV6 (show ETV6 Antibodies)-NTRK3-induced cellular transformation
This study demonistrated that NTRK3 plays a role in panic disorder by regulating hippocampus-dependent fear memories.
Despite elimination of TrkC mRNA, no differences in development of kindling were detected between TrkC conditional null and wild type control mice.
find that both IRS1 (show IRS1 Antibodies) and kinase active IGF1R (show IGF1R Antibodies) are required for ETV6 (show ETV6 Antibodies)-NTRK3 transformation, that tyrosine phosphorylated IRS1 (show IRS1 Antibodies) is present in high molecular weight complexes with EN and IGF1R (show IGF1R Antibodies), and that EN colocalizes with IGF1R (show IGF1R Antibodies) at the plasma membrane
Data describe the distribution and changes of TrkB (show NTRK2 Antibodies) and TrkC in the dopamine neurons of the substantia nigra by comparison of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP (show PTPN2 Antibodies)) Parkinson disease mouse model.
Data suggest that postsynaptic TrkC trans interaction with presynaptic PTPsigma (show PTPRS Antibodies) generates bidirectional adhesion and recruitment essential for excitatory synapse development and positions these signaling molecules at the center of synaptic pathways.
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
, ETV6-NTRK3 fusion
, NT-3 growth factor receptor
, tyrosine kinase receptor C
, neural receptor protein-tyrosine kinase (trkC)
, trkC tyrosine kinase
, neurotrophic tyrosine kinase receptor type 3
, tyrosine kinase C receptor, TrkC receptor, high-affinity neurotrophin receptor
, neurotrophic tyrosine kinase, receptor, type 3
, NT-3 growth factor receptor-like