NTRK3
(Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
Binding Specificity
Extracellular Domain
Reactivity
Rat
Host
Sheep
Clonality
Polyclonal
Conjugate
This NTRK3 antibody is un-conjugated
Application
Western Blotting (WB), Immunohistochemistry (IHC)
Specificity
Specific for TrkC.
Cross-Reactivity
Human, Mouse, Rat
Cross-Reactivity (Details)
Other species not yet tested.
Purification
IgG
Immunogen
A synthetic peptide from the extracellular domain of rat TrkC conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse, human and monkey.
IHC, WB (confirmed by recombinant protein). A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice
Avoid freeze and thaw cycles.
Storage
4 °C/-20 °C
Storage Comment
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months
Target
NTRK3
(Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
FUNCTION: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.,Neurotrophic Receptors,Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3