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these results indicate that PAK4 confers CDDP resistance via the activation of MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) and PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathways. PAK4 and PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathways can reciprocally activate each other.
PAK4 activity was markedly decreased in postmortem brain tissue from Parkinson's disease (PD) patients and in rodent models of PD. Expression of constitutively active PAK4(S445N/S474E) (caPAK4) protected DA neurons in both the 6-hydroxydopamine and alpha-synuclein rat models of PD and preserved motor function.
Our results indicate that PAK4 plays an important role in the potentiation of insulin secretion by fatty acids downstream of GPR40.
PAK4 downregulation decreased PPARgamma (show PPARG Proteins)-mediated Nox1 (show NOX1 Proteins) expression and suppressed EMT (show ITK Proteins) in IR-treated glioma cells.
miR (show MLXIP Proteins)-1271/Zic2 (show ZIC2 Proteins)/PAK4 axis plays an important role in hepatocellular carcinoma progression.
findings suggest that PAK4-activated PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling is both kinase-dependent and -independent, which contributes to breast cancer progression
Functional role and therapeutic targeting of PAK4 in multiple myeloma has been presented.
PAK4 overexpression in hepatocellular carcinoma (HCC (show FAM126A Proteins)) promotes metastatic invasion by regulating p53 (show TP53 Proteins) phosphorylation.
Study demonstrated that PAK4 interacted with eEF1A1 (show EEF1A1 Proteins) to promote migration and invasion of gastric cancer cells, thereby providing new insights into the function of PAK4 and eEF1A1 (show EEF1A1 Proteins) in the progression of gastric cancer.
The results support a novel connection between HIF-1a (show HIF1A Proteins) and Pak4 in hypoxic cancer cells, and provide insights into mechanisms whereby tumors respond to and thrive under oxygen-deficient conditions.
PAK4 microparticles may have a role in the ventilation-induced lung injury process
These data demonstrate the relevance of PAK4 in osteoclast differentiation and the potential of PAK4 inhibitors for treating osteoclast-related disorders.
PAK4 promotes alpha-MSH/UVB-induced melanogenesis via the CREB (show CREB1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathways and suggest that PAK4 may be a potential therapeutic target in pigmentation disorders.
PAK4 phosphorylates Par6B (show PARD6B Proteins) at Ser143 blocking its interaction with Cdc42 (show CDC42 Proteins).
Defined here is the overlap in phosphopeptides regulated by K-Ras (show HRAS Proteins), Cdc42 (show CDC42 Proteins), and PAK4; perturbation of these signaling components affects phosphoproteins associated with microtubule depolymerization, cytoskeletal organization, and the cell cycle.
These results indicate that PAK4 functions, including control of actin dynamics, are necessary for normal development of the heart
p21-activated kinase 4 regulates regulatory myosin light chain phosphorylation and myosin contractility during FcgammaR-mediated phagocytosis.
the transient increase in PAK4 levels at early G1 reduces p21 levels, thereby abrogating the activity of CDK4 (show CDK4 Proteins)/CDK6 (show CDK6 Proteins) kinases, and allowing cells to proceed with the cell cycle in a precisely coordinated way
Conditional Pak4 knockout mice were born normally, but displayed growth retardation and died prematurely. The brains showed a dramatic decrease in proliferation of cortical and striatal neuronal progenitor cells.
results suggest that overexpression of Pak4 triggers events that are important for the transformation of mammary epithelial cells
pak4 is dispensable in zebrafish.
Zebrafish pak4 is required for primitive myeloid cell development.
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, p21(CDKN1A)-activated kinase 4
, p21-activated kinase 4
, protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
, serine/threonine-protein kinase PAK 4
, p21 (CDKN1A)-activated kinase 4
, p21 protein (Cdc42/Rac)-activated kinase 4