Browse our PDGFB Proteins (PDGFB)

Human Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

1. This review showed that PDGFB was one of the common gene involved included with brain calcification.

2. Rare Skin Tumor Dermatofibrosarcoma Protuberans (DFSP) is characterized by the translocation of the PDGFB gene to the collagen 1A1 (show COL1A1 Proteins) gene.

3. Transglutaminase type 2 affects cell migration through post-translational modification of PDGF (show PDGFA Proteins)-BB.

4. PDGF-B rs1800818 polymorphism might play a role in mediating the susceptibility to severe fever with thrombocytopenia syndrome in Chinese individuals.

5. PDAP-1 (show PDAP1 Proteins) as an effecter of PDGF (show PDGFA Proteins) signaling in glioma cells

6. High PDGFB expression is associated with gastric cancer.

7. We observed that regenerating and necrotic muscle fibers in muscle biopsy samples from Duchenne muscular dystrophy (show DMD Proteins) patients expressed PDGF (show PDGFA Proteins)-BB.

8. Elevated PDGFB expression was noted in 29% of patients with papillary renal cell carcinoma (show MOK Proteins).

9. Insulin (show INS Proteins) treatment caused sustained Akt (show AKT1 Proteins) activity, whereas EGF (show EGF Proteins) or PDGF (show PDGFA Proteins)-AA promoted transient signaling; PDGF (show PDGFA Proteins)-BB produced sustained responses at higher concentrations.Transient responses to EGF (show EGF Proteins) were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I (show IGF1 Proteins) caused full Akt (show AKT1 Proteins) activation

10. high-throughput affinity plasma proteomic profiling is a valuable research strategy to identify potential candidate biomarkers for thrombosis-related disorders, and our study suggests a novel association of PDGFB plasma levels with venous thromboembolism.

Rhesus Monkey Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

1. intrinsic PDGF-B expressed in the spinal cord may play an essential role in neuroregulation in primates following cord hemisection

Cow (Bovine) Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

1. hypoxia increased the expression of platelet-derived growth factor (PDGF (show PDGFA Proteins)) and transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins)) and decreased the expression of neprilysin (NEP (show MME Proteins)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.

2. Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt (show AKT1 Proteins)/Stat3 (show STAT3 Proteins) signaling pathway.

3. PDGF-B transcription is increased by Nuclear Factor Kappa B

4. up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II (show AGT Proteins)-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation

5. PEDF promotes growth of pericytes through autocrine production of PDGFB.

6. Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.

Mouse (Murine) Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

1. Myeloid cell-derived PDGF (show PDGFA Proteins) contributes to vascular neotissue formation by regulating macrophage apoptosis, smooth muscle cell proliferation and extracellular matrix deposition.

2. These results demonstrate the requirement of lymphatic endothelial cells-autonomous PDGFB expression and retention for smooth muscle cell recruitment to lymphatic vessels.

3. Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS (show ROS1 Proteins), NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF (show VEGFA Proteins), FGF-2 (show FGF2 Proteins) and PDGF (show PDGFA Proteins)-BB.

4. PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.

5. data suggest that the stronger fibrotic effect generated by Pdgfa (show PDGFA Proteins) overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells

6. loss-of-function mutations in PDGFB or PDGFRB (show PDGFRB Proteins) cause Primary Familial Brain Calcification.

7. Results suggest that regional Pax3 (show PAX3 Proteins) expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis

8. High PDGFB expression is associated with liver fibrosis.

9. Increased expression of STAT5b (show STAT5B Proteins) + PDGFB led to increased expression of downstream STAT5b (show STAT5B Proteins) targets.

10. Platelets produce PDGFB to activate stellate cells and promote fibrosis in MDR2 (show ABCB4 Proteins)-null mice.