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Human Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

1. PDGF-B expression was found in ovarian tumor microvessels in 72% of cases. High expression of PDGF (show PDGFA Proteins) in pericapillary cells was strongly associated with high expression of this marker in cancer cells. Significant correlations between PDGF-B and nestin (show NES Proteins) expression in malignant tumor microvessels were also found.

2. SOX7 transcription factor (show SOX7 Proteins) mediates PDGF (show PDGFA Proteins)-BB-induced IL-33 (show IL33 Proteins) expression.

3. High expression of PDGF (show PDGFA Proteins)-BB may be involved in the pathogenesis of Graves' disease. CCR2 (show CCR2 Proteins)-positive macrophages may induce the expression of PDGF (show PDGFA Proteins)-BB through HIF-1alpha (show HIF1A Proteins) signal.

4. rhPDGF-BB promoted the proliferation of hADSCs via miR (show MLXIP Proteins)-363/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway, indicating that rhPDGF-BB combined with ADSCs could treat Achilles tendinitis via miR (show MLXIP Proteins)-363/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway.

5. This review showed that PDGFB was one of the common gene involved included with brain calcification.

6. Rare Skin Tumor Dermatofibrosarcoma Protuberans (DFSP) is characterized by the translocation of the PDGFB gene to the collagen 1A1 (show COL1A1 Proteins) gene.

7. Transglutaminase type 2 affects cell migration through post-translational modification of PDGF (show PDGFA Proteins)-BB.

8. PDGF-B rs1800818 polymorphism might play a role in mediating the susceptibility to severe fever with thrombocytopenia syndrome in Chinese individuals.

9. PDAP-1 (show PDAP1 Proteins) as an effecter of PDGF (show PDGFA Proteins) signaling in glioma cells

10. High PDGFB expression is associated with gastric cancer.

Rhesus Monkey Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

1. intrinsic PDGF-B expressed in the spinal cord may play an essential role in neuroregulation in primates following cord hemisection

Cow (Bovine) Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

1. hypoxia increased the expression of platelet-derived growth factor (PDGF (show PDGFA Proteins)) and transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins)) and decreased the expression of neprilysin (NEP (show MME Proteins)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.

2. Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt (show AKT1 Proteins)/Stat3 (show STAT3 Proteins) signaling pathway.

3. PDGF-B transcription is increased by Nuclear Factor Kappa B

4. up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II (show AGT Proteins)-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation

5. PEDF promotes growth of pericytes through autocrine production of PDGFB.

6. Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.

Mouse (Murine) Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

1. microRNA let-7g suppresses PDGF (show PDGFA Proteins)-induced conversion of vascular smooth muscle cell into the atherosclerotic phenotype.

2. The PDGFB-overexpressing murine tumors closely cluster with human proneural and mesenchymal subtypes, as well as PDGFRA (show PDGFRA Proteins)-amplified at both the RNA and protein expression levels. These models can be generated in fully immunocompetent mixed or C57BL/6 genetic background mice, and therefore can easily be incorporated into preclinical studies for cancer cell-specific or immune cell-targeting drug discovery studies.

3. Myeloid cell-derived PDGF (show PDGFA Proteins) contributes to vascular neotissue formation by regulating macrophage apoptosis, smooth muscle cell proliferation and extracellular matrix deposition.

4. These results demonstrate the requirement of lymphatic endothelial cells-autonomous PDGFB expression and retention for smooth muscle cell recruitment to lymphatic vessels.

5. Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS (show ROS1 Proteins), NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF (show VEGFA Proteins), FGF-2 (show FGF2 Proteins) and PDGF (show PDGFA Proteins)-BB.

6. PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.

7. data suggest that the stronger fibrotic effect generated by Pdgfa (show PDGFA Proteins) overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells

8. loss-of-function mutations in PDGFB or PDGFRB (show PDGFRB Proteins) cause Primary Familial Brain Calcification.

9. Results suggest that regional Pax3 (show PAX3 Proteins) expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis

10. High PDGFB expression is associated with liver fibrosis.

Wheat germ Platelet-Derived Growth Factor beta Polypeptide (PDGFB) interaction partners

1. Data indicate a significant impairment of the activation mechanisms by PDGF (show PDGFA Proteins)-BB was shown after a hammerhead ribozyme targeting the membrane receptor PDGFR-beta (show PDGFRB Proteins) was applied.