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Syk (show SYK Proteins)-induced signals in bone marrow stromal cell lines are mediated by phospholipase C (show PLC Proteins) gamma1 (PLCgamma1 (show PLCG1 Proteins)) in osteogenesis and PLCgamma2 in adipogenesis.
Results show that mice with the mutated Plcg2 gene were less prone to transformation into MALT lymphomas as a result of elevated Treg numbers, and decrease of pro-inflammatory cytokines.
PLCgamma2 in clear cells plays an essential role in luminal expansion of the epididymis during the prepubertal period in mice
platelet activation through GPVI (show GP6 Proteins) and alphaIIbbeta3 utilizes PLCgamma2 because PLCgamma1 (show PLCG1 Proteins) levels are insufficient to support responsiveness, but that PLCgamma1 (show PLCG1 Proteins) can restore responsiveness if expressed at levels normally achieved by PLCgamma2.
amarogentin prevents platelet activation through the inhibition of PLC (show HSPG2 Proteins) gamma2-PKC cascade and MAPK (show MAPK1 Proteins) pathway
PLCgamma2 and protein kinase C are important upstream signals that regulate myelopoiesis through cytokines.
inflammatory osteolysis can be abrogated by treatment with a molecule composed of the tandem SH2 domains of PLCgamma2.
down-regulation of PLCgamma2-beta-catenin (show CTNNB1 Proteins) pathway occurs in mice and humans and leads to myeloid-derived suppressor cells-mediated tumor expansion.
a novel role of the PLCgamma2-IP(3)-Ca(2 (show CA2 Proteins)+) cascade in the LPS (show TLR4 Proteins)-induced innate immune response pathway where release of intracellular Ca(2 (show CA2 Proteins)+) mediates TLR4 (show TLR4 Proteins) trafficking and subsequent activation of IRF3 (show IRF3 Proteins).
VapB (show VAPB Proteins) positively regulates RANKL (show TNFSF11 Proteins)-mediated osteoclastogenesis via PLCgamma2-Ca(2 (show CA2 Proteins)+)-NFAT (show NFATC1 Proteins) signaling
finding that mutations or polymorphisms in two putative calcium-regulated domains of PLCG2 are associated with ibrutinib-resistant CLL adds to the evidence supporting complex regulatory shifts in the PLCG2 protein likely occurring during the development of resistance
Data show that protein-altering changes are in PLCG2, ABI3 (show ABI3 Proteins), and TREM2 (show TREM2 Proteins) genes highly expressed in microglia and highlight an immune-related protein-protein interaction network in Alzheimer's disease.
Ocular manifestations of phospholipase-Cgamma2-associated antibody deficiency and immune dysregulation show mutations in the PLC (show HSPG2 Proteins)[gamma]2 gene leading to aberrant function of immune cells and overproduction of interleukin-1 [beta] (IL-1 (show IL1A Proteins)[beta]).
R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 Rerouting of the transmembrane signals emanating from BCR (show BCR Proteins) and converging on PLCgamma2 through Rac (show AKT1 Proteins) in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 mutations or to prevent its development in ibrutinib-treated CLL patients.
Data show that phospholipase Cgamma2 (PLCgamma2) is strongly expressed in B cell non-Hodgkin lymphoma and especially in a large subset of Diffuse large B-cell lymphoma (DLBCL).
Characterization of the effect of missense point-mutation at R665W in PLCG2 on signaling mechanisms of ibrutinib resistance in chronic lymphocytic leukemia cells.
amarogentin prevents platelet activation through the inhibition of PLC (show HSPG2 Proteins) gamma2-PKC (show PRRT2 Proteins) cascade and MAPK (show MAPK1 Proteins) pathway
PLCG2 missense mutation is a risk factor in the development of steroid sensitive nephrotic syndrome in childhood.
The autoinhibitory C-terminal SH2 domain of phospholipase C (show PLC Proteins)-gamma2 stabilizes B cell receptor signalosome assembly.
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
, phosphoinositide phospholipase C-gamma-2
, phospholipase C-gamma-2
, phosphoinositide phospholipase C
, phospholipase C-IV
, phosphatidylinositol-specific phospholipase C