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anti-Human Pleiotrophin Antibodies:
anti-Mouse (Murine) Pleiotrophin Antibodies:
anti-Rat (Rattus) Pleiotrophin Antibodies:
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Human Monoclonal Pleiotrophin Primary Antibody for IHC (p), ELISA - ABIN562528
Koutsioumpa, Hatziapostolou, Mikelis, Koolwijk, Papadimitriou: Aprotinin stimulates angiogenesis and human endothelial cell migration through the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta. in European journal of pharmacology 2009
Show all 7 Pubmed References
Human Polyclonal Pleiotrophin Primary Antibody for ELISA, WB - ABIN5692922
Zhang, Liu, Liu, Zhou, Song, Cao, An: miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression. in PLoS ONE 2017
Human Polyclonal Pleiotrophin Primary Antibody for ELISA, WB - ABIN4346164
Kretschmer, Fairhurst, Hulmes, Popjes, Böhlen, Kovesdi: Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant. in Biochemical and biophysical research communications 1993
Human Polyclonal Pleiotrophin Primary Antibody for EIA, IHC (p) - ABIN115512
Asari, Kanemitsu, Kurihara: Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium. in The Journal of biological chemistry 2010
Show all 5 Pubmed References
zebrafish HBNF was able to enhance extensive neurite outgrowth in zebrafish embryos during embryogenesis
a heparin-binding growth factor, produced mainly by glia cells, was the predominant binding partner for chondroitin and dermatan sulfate hybrid chain biosynthesis.
Molecular crosstalk between tumour-associated macrophages and glioma stem cells through PTN-PTPRZ1 paracrine signalling supports glioblastoma malignant growth.
Expression of Mac-1 on the surface of human embryonic kidney (HEK) 293 cells induced their adhesion and migration to PTN. Accordingly, PTN promoted Mac-1-dependent cell spreading and initiated intracellular signaling manifested in phosphorylation of Erk1/2.
This study showed that increased serum pleiotrophin levels are associated with better developed coronary collateral circulation in patients with chronic total occlusion in at least one major coronary artery.
Pleiotrophin, a target of miR-384, promotes proliferation, metastasis and lipogenesis in hepatitis B virus-related hepatocellular carcinoma.
Elevated plasma midkine and pleiotrophin levels in systemic lupus erythematosus (SLE) patients suggest their involvement in this disease.
High PTN and N-syndecan expression was closely associated with metastasis and poor prognosis, suggesting that they may promote tumor progression and perineural invasion in the orthotopic mouse model of pancreatic cancer.
PTN expression in glioma cells is associated with chromosome 7 gain. PTN enhances PDGFB-induced gliomagenesis by stimulating proliferation of neural progenitor cells.
an early extracellular space disruption of PTN composition induces short- and long-term defaults in the establishment of proper functional cerebellar circuit.
NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin and osteoglycin.
PTN knockdown attenuated the progression of experimental PVR in vivo. These findings provide new insights into the pathogenesis of PVR.
Annealing helicase HARP closes RPA-stabilized DNA bubbles non-processively.
Neural precursor cell (NPC):glioma cell communication underpins the propensity of glioma to colonize the lateral ventricle subventricular zone (SVZ) through secretion of chemoattractant signals toward which glioma cells home; analyses of SVZ NPC-secreted factors revealed the neurite outgrowth-promoting factor pleiotrophin, with required SPARC/SPARCL1 and HSP90B as mediators of this chemoattractant effect.
these data indicate that PTN-PTPRZ-A signaling controls the timing of oligodendrocyte precursor cell differentiation in vivo, in which the CS moiety of PTPRZ receptors maintains them in a monomeric active state until its ligand binding.
PTN could be considered as a potential biomarker for the presence of breast cancer.
this study shows that the expression of PTN is significantly downregulated in keloid fibroblasts compared to normal human fibroblasts
findings link pleiotrophin abundance in gliomas with survival in humans and mice, and show that pleiotrophin promotes glioma progression through increased VEGF deposition and vascular abnormalization.
PTN levels in amniotic fluid were found to be lower in pregnancies complicated by chorioamnionitis than in healthy pregnancies.
Increased Pleiotrophin Concentrations in Papillary Thyroid Cancer
Data show that binding of pleiotrophin (PTN) to neuropilin-1 (NRP-1) stimulated the internalization and recycling of NRP-1 at the cell surface.
PTN and its signaling components may be of significance in the pathogenesis of epithelial ovarian cancer.
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation (By similarity).
heparin-binding neurite-promoting factor
, pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
, heparin affin regulatory protein
, heparin binding growth factor 8
, heparin-binding brain mitogen
, heparin-binding growth factor 8
, heparin-binding growth-associated molecule
, heparin-binding neurite outgrowth-promoting factor 1
, neurite growth-promoting factor 1
, osteoblast-specific factor 1
, pleiotrophic factor-beta-1
, heparin-binding neutrophic factor
, heparin affin regulatory peptide
, heparin-binding neurite promoting factor
, heparin-binding neurotorphic factor
, osteoblastic cell factor
, Pleiotrophin (Heparine binding factor, Hbnf, in the mouse)
, heparin binding factor