Pleiotrophin antibody

Catalog No. ABIN7238324

This Rabbit Polyclonal antibody specifically detects Pleiotrophin in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Pleiotrophin antibody (ABIN7238324)

Target: Pleiotrophin (PTN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Pleiotrophin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Pleiotrophin Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human PTN

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Pleiotrophin

Target: Pleiotrophin (PTN)

Alternative Name: PTN

Background: Pleiotrophin(PTN) also known asheparin-binding brain mitogen(HBBM) orheparin-binding growth factor 8(HBGF-8) orneurite growth-promoting factor 1(NEGF1) orheparin affinity regulatory peptide(HARP) orheparin binding growth associated molecule(HB-GAM) is aproteinthat in humans is encoded by thePTNgene.Pleiotrophin is an 18- kDagrowth factorthat has a high affinity forheparin. It is structurally related tomidkineandretinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.

Molecular Weight: 19 kDa

NCBI Accession: NP_002816

UniProt: P21246

Pathways: RTK Signaling