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Mutation in PPP3CA gene is associated with Severe Neurodevelopmental Disease with Seizures.
identify a distinct C-terminal autoinhibitory four-residue sequence in CNAbeta1, (462)LAVP(465), which competitively inhibits substrate dephosphorylation. In vitro and cell-based assays revealed that the CNAbeta1-containing holoenzyme, CNbeta1, is autoinhibited at a single site by either of two inhibitory regions, CBD (show OPN1MW Proteins) and LAVP, which block substrate access to the substrate-binding groove.
Studies indicate the importance of the AKAP79 (show AKAP5 Proteins)/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 (show CA1 Proteins) region of the hippocampus.
Ca(2 (show CA2 Proteins)+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT (show NFATC1 Proteins)) c4 axis is required for neuritin (show NRN1 Proteins)-induced Kv4.2 (show KCND2 Proteins) transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
CN-A and nephrin were (show CABIN1 Proteins) clearly reduced in the kidneys of a 10-year-old boy who had relapsing steroid-resistant nephrotic syndrome (show NPHS1 Proteins).
that KIF1Bbeta affects mitochondrial dynamics through calcineurin-dependent dephosphorylation of Dynamin-related protein 1 (DRP1 (show DNM1L Proteins)), causing mitochondrial fission and apoptosis
for Aspergillus fumigatus, activation of macrophage calcineurin-NFAT (show NFATC1 Proteins) occurs via a phagosomal TLR9 (show TLR9 Proteins)-dependent and Bruton's tyrosine kinase (show BTK Proteins)-dependent signalling pathway that is independent of MyD88 (show MYD88 Proteins)
Data indicate that both nuclear factors of activated T cells (NFATs) motifs partially compete for binding but do not fully displace each other on the calcineurin (Cn) epitope.
Lysosomal calcium signaling regulates autophagy through calcineurin and TFEB (show TFEB Proteins).
Human herpesvirus 6B U54 binds the calcineurin (CaN) phosphatase enzyme, causing improper dephosphorylation and nuclear translocation of NFAT (show NFATC1 Proteins) (nuclear factor of activated T cells) proteins, resulting in suboptimal IL-2 (show IL2 Proteins) gene transcription.
these results demonstrate that increased susceptibility to Aspergillus fumigatus is dependent on calcineurin signaling in myeloid cells
the CaN-Nfat (show NFATC1 Proteins) pathway regulates development and function of IFN-gamma (show IFNG Proteins)-producing gammadelta T cells.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction.
Calcineurin inhibitor (show RCAN1 Proteins) tacrolimus ameliorated proteinuria in nephrotic model by inhibiting the redistribution of CN-A and nephrin (show NPHS1 Proteins) at the slit diaphragm.
global deficiency of catalytic subunit Ppp3cb (show PPP3CB Proteins), and tissue-specific ablation of regulatory subunit Ppp3r1 (show PPP3R1 Proteins) from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity
Overexpression of the phosphatase calcineurin A prevents the development of a capillary/myocyte mismatch despite progressive myocardial hypertrophy.
Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB (show NFKB1 Proteins)-inducing kinase (NIK (show MAP4K4 Proteins)) and attenuate NIK (show MAP4K4 Proteins)-dependent gene expression
Data indicate that calcineurin (CnAalpha-/- or CnAbeta (show PPP3CB Proteins)-/-) is required for pathological but not compensatory renal hypertrophy.
The calmodulin binding region from residues 389 to 420 was modeled based on the structure of two other proteins having calmodulin binding domains with the same 1-8-14 structural motif as calcineurin.
catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase\; mediates activities of transcription factors and ion channels\; involved in regulation of T-cell activation
CAM-PRP catalytic subunit
, calcineurin A alpha
, calmodulin-dependent calcineurin A subunit alpha isoform
, protein phosphatase 2B, catalytic subunit, alpha isoform
, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
, PP2B alpha 1
, PP2BA alpha
, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
, protein phosphatase 3, catalytic subunit, alpha isoform
, Calcineurin subunit A alpha
, protein phosphatase-2Ba
, calcineurin catalytic subunit delta isoform
, calcineurin catalytic subunit
, protein phosphatase 3, catalytic subunit, alpha isozyme
, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like