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Full name:: Protein Phosphatase 3, Catalytic Subunit, alpha Isoform Proteins (PPP3CA)

On www.antibodies-online.com are 11 Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) Proteins from 7 different suppliers available. Additionally we are shipping PPP3CA Antibodies (122) and PPP3CA Kits (31) and many more products for this protein. A total of 171 PPP3CA products are currently listed.

Synonyms:: 2900074D19Rik, AI841391, AW413465, calcineurin, caln, calna, calna1, ccn1, CN, CnA, cna1, fj46e08, ppp2b, ppp3ca, si:dkeyp-79c2.2, wu:fj46e08

list all proteins	Gene Name	GeneID	UniProt
	PPP3CA	5530	Q08209
	PPP3CA	19055	P63328
	PPP3CA	24674	P63329
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Human Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) interaction partners

Mutation in PPP3CA gene is associated with Severe Neurodevelopmental Disease with Seizures.
identify a distinct C-terminal autoinhibitory four-residue sequence in CNAbeta1, (462)LAVP(465), which competitively inhibits substrate dephosphorylation. In vitro and cell-based assays revealed that the CNAbeta1-containing holoenzyme, CNbeta1, is autoinhibited at a single site by either of two inhibitory regions, CBD (show OPN1MW Proteins) and LAVP, which block substrate access to the substrate-binding groove.
Studies indicate the importance of the AKAP79 (show AKAP5 Proteins)/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 (show CA1 Proteins) region of the hippocampus.
Ca(2 (show CA2 Proteins)+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT (show NFATC1 Proteins)) c4 axis is required for neuritin (show NRN1 Proteins)-induced Kv4.2 (show KCND2 Proteins) transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
CN-A and nephrin were (show CABIN1 Proteins) clearly reduced in the kidneys of a 10-year-old boy who had relapsing steroid-resistant nephrotic syndrome (show NPHS1 Proteins).
that KIF1Bbeta affects mitochondrial dynamics through calcineurin-dependent dephosphorylation of Dynamin-related protein 1 (DRP1 (show DNM1L Proteins)), causing mitochondrial fission and apoptosis
for Aspergillus fumigatus, activation of macrophage calcineurin-NFAT (show NFATC1 Proteins) occurs via a phagosomal TLR9 (show TLR9 Proteins)-dependent and Bruton's tyrosine kinase (show BTK Proteins)-dependent signalling pathway that is independent of MyD88 (show MYD88 Proteins)
Data indicate that both nuclear factors of activated T cells (NFATs) motifs partially compete for binding but do not fully displace each other on the calcineurin (Cn) epitope.
Lysosomal calcium signaling regulates autophagy through calcineurin and TFEB (show TFEB Proteins).
Human herpesvirus 6B U54 binds the calcineurin (CaN) phosphatase enzyme, causing improper dephosphorylation and nuclear translocation of NFAT (show NFATC1 Proteins) (nuclear factor of activated T cells) proteins, resulting in suboptimal IL-2 (show IL2 Proteins) gene transcription.

Mouse (Murine) Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) interaction partners

these results demonstrate that increased susceptibility to Aspergillus fumigatus is dependent on calcineurin signaling in myeloid cells
the CaN-Nfat (show NFATC1 Proteins) pathway regulates development and function of IFN-gamma (show IFNG Proteins)-producing gammadelta T cells.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
Ca(2 (show CA2 Proteins)+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT (show NFATC1 Proteins)) c4 axis is required for neuritin (show NRN1 Proteins)-induced Kv4.2 (show KCND2 Proteins) transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction.
Calcineurin inhibitor (show RCAN1 Proteins) tacrolimus ameliorated proteinuria in nephrotic model by inhibiting the redistribution of CN-A and nephrin (show NPHS1 Proteins) at the slit diaphragm.
global deficiency of catalytic subunit Ppp3cb (show PPP3CB Proteins), and tissue-specific ablation of regulatory subunit Ppp3r1 (show PPP3R1 Proteins) from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity
Overexpression of the phosphatase calcineurin A prevents the development of a capillary/myocyte mismatch despite progressive myocardial hypertrophy.
Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB (show NFKB1 Proteins)-inducing kinase (NIK (show MAP4K4 Proteins)) and attenuate NIK (show MAP4K4 Proteins)-dependent gene expression
Data indicate that calcineurin (CnAalpha-/- or CnAbeta (show PPP3CB Proteins)-/-) is required for pathological but not compensatory renal hypertrophy.

Cow (Bovine) Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) interaction partners

The calmodulin binding region from residues 389 to 420 was modeled based on the structure of two other proteins having calmodulin binding domains with the same 1-8-14 structural motif as calcineurin.

Pig (Porcine) Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) interaction partners

PPP3CA Protein Profile

Protein Summary

catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase\; mediates activities of transcription factors and ion channels\; involved in regulation of T-cell activation

Alternative names and synonyms associated with PPP3CA

protein phosphatase 3 catalytic subunit alpha (PPP3CA)
protein phosphatase 3, catalytic subunit, alpha isoform (Ppp3ca)
protein phosphatase 3, catalytic subunit, alpha isozyme (PPP3CA)
protein phosphatase 3 catalytic subunit alpha (Ppp3ca)
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) (ppp3ca)
protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog (ppp3ca.L)
protein phosphatase 3, catalytic subunit, alpha isozyme (ppp3ca)
serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (LOC100205420)

2900074D19Rik protein
AI841391 protein
AW413465 protein
calcineurin protein
caln protein
calna protein
calna1 protein
ccn1 protein
CN protein
CnA protein
cna1 protein
fj46e08 protein
ppp2b protein
ppp3ca protein
si:dkeyp-79c2.2 protein
wu:fj46e08 protein

Protein level used designations for PPP3CA

CAM-PRP catalytic subunit , calcineurin A alpha , calmodulin-dependent calcineurin A subunit alpha isoform , protein phosphatase 2B, catalytic subunit, alpha isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform , serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform , PP2B alpha 1 , PP2BA alpha , protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) , protein phosphatase 3, catalytic subunit, alpha isoform , Calcineurin subunit A alpha , protein phosphatase-2Ba , calcineurin catalytic subunit delta isoform , calcineurin catalytic subunit , protein phosphatase 3, catalytic subunit, alpha isozyme , serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like

GENE ID	SPECIES
5530	Homo sapiens
19055	Mus musculus
286852	Bos taurus
395113	Gallus gallus
24674	Rattus norvegicus
380507	Xenopus laevis
397241	Sus scrofa
403486	Canis lupus familiaris
447196	Xenopus laevis
461403	Pan troglodytes
709773	Macaca mulatta
794574	Danio rerio
100014900	Monodelphis domestica
100067434	Equus caballus
100083890	Ornithorhynchus anatinus
100144934	Xenopus (Silurana) tropicalis
100174530	Pongo abelii
100205420	Hydra magnipapillata
100386369	Callithrix jacchus
100547009	Meleagris gallopavo
100583664	Nomascus leucogenys

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