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PP2B activity was higher with phosphotyrosine in presence of Ca(2+) than with p-NPP. Further experiments, involving calmodulin as a modulator, confirmed phosphotyrosine as a better substrate
An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha (show NFKBIA Proteins)/NF-kappaB (show NFKB1 Proteins)(p65 (show NFkBP65 Proteins)), miR (show MLXIP Proteins)-196b-3p, Meis2 (show MEIS2 Proteins), and PPP3CC is formed during the emergence of castration-resistant prostate cancer.
this stusy demonstrates that male mice lacking Ppp3cc or Ppp3r2 genes (knockout mice) are infertile, with reduced sperm motility owing to an inflexible midpiece.
The PPP3CC involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation.
protein level of PPP3CC negatively correlates with the cellular level of IP3, suggesting a regulatory role of PPP3CC in the IP3-Ca2 (show CA2 Proteins)+ signaling pathway
study suggests that NMDA receptor-mediated signalling genes, DAO (show ABP1 Proteins), PPP3CC, DTNBP1 (show DTNBP1 Proteins) might be involved in schizophrenia pathogenic mechanisms related to gender
This study demoistrated that PPP3CC are not genetic risk factors for schizophrenia in japanese.
results identify PPP3CC, located at 8p21.3, as a potential schizophrenia susceptibility gene and support the proposal that alterations in calcineurin signaling contribute to schizophrenia pathogenesis
Decreased hippocampal expression of the susceptibility gene PPP3CC in schizophrenia.
PPP3CC may not play a major role in Japanese schizophrenia
The results suggest that PPP3CC gene may be a true susceptibility gene for schizophrenia.
The Polymorphism, Single Nucleotide of ppp3cc is assosciated with schizophrenia.
No significant differences in calcineurin A gamma expression was observed between patients with schizophrenia and normal controls
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene.
calcineurin A gamma
, protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform
, serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
, protein phosphatase 3, catalytic subunit, gamma isoform-like
, protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)
, protein phosphatase 3, catalytic subunit, gamma isozyme
, serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like
, CAM-PRP catalytic subunit
, PP2BA gamma
, calcineurin, testis-specific catalytic subunit
, calmodulin-dependent calcineurin A subunit gamma isoform
, protein phosphatase 2B, catalytic subunit, gamma isoform
, protein phosphatase 3 catalytic subunit gamma
, protein phosphatase 3, catalytic subunit, gamma isoform