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anti-Human PTK7 Antibodies:
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Human Polyclonal PTK7 Primary Antibody for IHC, ELISA - ABIN1003048
Park, Lee, Lee: Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. in Journal of biochemistry 1997
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Human Polyclonal PTK7 Primary Antibody for IHC, ELISA - ABIN1003049
Müller-Tidow, Schwäble, Steffen, Tidow, Brandt, Becker, Schulze-Bahr, Halfter, Vogt, Metzger, Schneider, Büchner, Brandts, Berdel, Serve: High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets. in Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Show all 4 Pubmed References
Human Monoclonal PTK7 Primary Antibody for IHC, ELISA - ABIN969374
Shin, Maeng, Jung, Min, Kwon, Lee: Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis. in Biochemical and biophysical research communications 2008
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Human Polyclonal PTK7 Primary Antibody for IHC (p), WB - ABIN2476280
Easty, Mitchell, Patel, Flørenes, Spritz, Bennett: Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma. in International journal of cancer. Journal international du cancer 1997
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Human Polyclonal PTK7 Primary Antibody for FACS, IHC (p) - ABIN392230
Wang, Li, Yin, Wang, Wang, Wei, Guo, Ma, Shi, Zhou, Wang: PTK7 protein is decreased in epithelial ovarian carcinomas with poor prognosis. in International journal of clinical and experimental pathology 2014
Inhibition of PTK7 by siRNA treatment significantly decreases the viability of atypical teratoid rhabdoid tumors (ATRT)patient-derived tumor cell lines.These studies provide the groundwork for future preclinical in vivo studies aiming to investigate the efficacy of PTK7 inhibition on ATRT tumor growth
PTK7 localization and protein stability is affected by canonical Wnt (show WNT2 Antibodies) ligands.
These findings demonstrate that PTK7 upregulates MMP9 (show MMP9 Antibodies) through activation of AP-1 (show FOSB Antibodies) and NF-kappaB (show NFKB1 Antibodies) and, thus increases invasive properties of ESCC cells.
PTK7 overexpression is associated with esophageal squamous cell carcinoma.
Our data indicate that PTK7 protein expression is associated with the prognosis of oral tongue squamous cell carcinoma
PTK7 expression was correlated with tumor differentiation (P=0.027), lymph node metastasis (P=0.005), distant metastasis (P=0.001) and TNM (show ODZ1 Antibodies) stage (P=0.028) of colorectal cancer patients
High PTK7 expression is associated with radioresistance in esophageal squamous cell carcinoma.
PTK7 enriches in self-renewing, multipotent stem cells of the human colon.
findings implicate PTK7 as a risk factor for NTDs and provide additional evidence for a pathogenic role of PCP (show PRCP Antibodies) signaling in these malformations
overexpression in PTK7-negative cancer cells led to increased metastatic events. PTK7 expression thus represents a potential prognostic biomarker and a novel therapeutic target in CRC (show CALR Antibodies).
PTK7 regulates extracellular matrix integrity and the activity levels of RAC1 and myosin II, which in turn regulates Wolffian duct morphogenesis and therefore, epididymal function.
In a Ptk7-deficient mouse strain, loss of Ptk7 leads to a diminished pool of hematopoietic stem cells but does not affect in vitro or in vivo differentiation. This is correlated with increased quiescence and reduced homing abilities of Ptk7-deficient hematopoietic stem and progenitor cells.
Data suggest that protein tyrosine kinase 7 (PTK7) is essential for Wolffian duct morphogenesis and male fertility.
data demonstrates that PTK7 regulates the activity of KDR (show KDR Antibodies) biphasically by inducing oligomerization of KDR (show KDR Antibodies) molecules at lower concentrations and by surrounding KDR (show KDR Antibodies) molecules at higher concentrations.
PTK7 expression plays an important role in the invasiveness of intrahepatic cholangiocarcinoma cells.
Planar polarity of neural cell motility and intercalation requires Ptk7 function.
acts in conjunction with the noncanonical Wnt pathway to orient epithelial planar cell polarity through modulation of myosin II-based contractile tension between supporting cells and hair cells
The tyrosine kinase receptor (show KDR Antibodies), PTK7, is implicated in beta-catenin (show CTNNB1 Antibodies)-dependent developmental processes.
These findings illustrate a novel and pivotal role for Cdx (show CDX1 Antibodies) function upstream of Ptk7 and neural tube closure in vertebrates.
Chuzhoi mutation, that causes multiple abnormalities maps, to Chromosome 17 and carries a splice site mutation in Ptk7 and causes disruption of Ptk7 protein expression.
This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PTK7 protein tyrosine kinase 7
, inactive tyrosine-protein kinase 7
, tyrosine-protein kinase-like 7-like
, colon carcinoma kinase 4
, pseudo tyrosine kinase receptor 7
, tyrosine-protein kinase-like 7
, serum response factor
, protein chuzhoi
, protein-tyrosine kinase 7
, receptor tyrosine kinase-like protein
, kinase-like protein