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PTK7 overexpression is associated with esophageal squamous cell carcinoma.
Our data indicate that PTK7 protein expression is associated with the prognosis of oral tongue squamous cell carcinoma
PTK7 expression was correlated with tumor differentiation (P=0.027), lymph node metastasis (P=0.005), distant metastasis (P=0.001) and TNM (show ODZ1 Proteins) stage (P=0.028) of colorectal cancer patients
High PTK7 expression is associated with radioresistance in esophageal squamous cell carcinoma.
PTK7 enriches in self-renewing, multipotent stem cells of the human colon.
findings implicate PTK7 as a risk factor for NTDs and provide additional evidence for a pathogenic role of PCP (show PRCP Proteins) signaling in these malformations
overexpression in PTK7-negative cancer cells led to increased metastatic events. PTK7 expression thus represents a potential prognostic biomarker and a novel therapeutic target in CRC (show CALR Proteins).
data demonstrates that PTK7 regulates the activity of KDR (show KDR Proteins) biphasically by inducing oligomerization of KDR (show KDR Proteins) molecules at lower concentrations and by surrounding KDR (show KDR Proteins) molecules at higher concentrations.
PTK7 regulates Id1 (show ID1 Proteins) expression in CD44 (show CD44 Proteins)-high glioma cell lines. Targeting PTK7 could be an effective strategy for treating glioma with high CD44 (show CD44 Proteins) expression.
The results suggest that N-acylethanolamine acid amidase (show NAAA Proteins) and protein tyrosine kinase 7 may be used as potential tissue biomarkers to avoid overtreatment of non-aggressive prostate cancer
In a Ptk7-deficient mouse strain, loss of Ptk7 leads to a diminished pool of hematopoietic stem cells but does not affect in vitro or in vivo differentiation. This is correlated with increased quiescence and reduced homing abilities of Ptk7-deficient hematopoietic stem and progenitor cells.
Data suggest that protein tyrosine kinase 7 (PTK7) is essential for Wolffian duct morphogenesis and male fertility.
PTK7 expression plays an important role in the invasiveness of intrahepatic cholangiocarcinoma cells.
Planar polarity of neural cell motility and intercalation requires Ptk7 function.
acts in conjunction with the noncanonical Wnt pathway to orient epithelial planar cell polarity through modulation of myosin II-based contractile tension between supporting cells and hair cells
The tyrosine kinase receptor (show KDR Proteins), PTK7, is implicated in beta-catenin (show CTNNB1 Proteins)-dependent developmental processes.
These findings illustrate a novel and pivotal role for Cdx (show CDX1 Proteins) function upstream of Ptk7 and neural tube closure in vertebrates.
Chuzhoi mutation, that causes multiple abnormalities maps, to Chromosome 17 and carries a splice site mutation in Ptk7 and causes disruption of Ptk7 protein expression.
Ptk7 mRNA was expressed at high levels in lung and un-pregnant uterus among adult tissues, and in the tail, limbs, somites, gut (show GUSB Proteins), and craniofacial regions among embryonic tissues, and suggest that PTK7 plays multiple roles in embryonic development.
This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PTK7 protein tyrosine kinase 7
, inactive tyrosine-protein kinase 7
, tyrosine-protein kinase-like 7-like
, colon carcinoma kinase 4
, pseudo tyrosine kinase receptor 7
, tyrosine-protein kinase-like 7
, serum response factor
, protein chuzhoi
, protein-tyrosine kinase 7
, receptor tyrosine kinase-like protein
, kinase-like protein