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These data provide the first evidence for a physiologic role of these isoforms in RET pathway function.
Significantly, we show that introduction of mapk10 (show MAPK10 Proteins) mutations into ret heterozygotes enhanced the ENS deficit, supporting MAPK10 (show MAPK10 Proteins) as a Hirschsprung disease (HSCR (show EDNRB Proteins)) susceptibility locus. Our studies demonstrate that ret heterozygous zebrafish is a sensitized model, with many significant advantages over existing murine models, to explore the pathophysiology and complex genetics of HSCR (show EDNRB Proteins).
RET expression is investigated within the brain of zebrafish; both RET protein and mRNA are observed.
In animals lacking Ret or Gfra3 (show GFRA3 Proteins) function, myogenic gene expression is reduced in forming opercular muscles, but not in non-opercular muscles derived from the same muscle anlagen.
evaluation of noncoding sequences at the zebrafish ret locus conserved among teleosts, and at the human RET locus, conserved among mammals
genes beyond RET may be implicated in the genesis of sporadic cases of HD
The cardiac GFRA2 (show GFRA2 Proteins) signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase (show TXK Proteins).
Nuclease (show DCLRE1C Proteins)-resistant aptamers that recognize the human receptor tyrosine kinase RET were obtained using RET-expressing cells as targets in a modified random pool of sequences.
identified four genomic rearrangements involving the genes BRAF, RET, and ROS1
Detection of Gene Rearrangements in Circulating Tumor Cells: Examples of ALK-, ROS1 (show ROS1 Proteins)-, RET-Rearrangements in Non-Small-Cell Lung Cancer and ERG (show ERG Proteins)-Rearrangements in Prostate Cancer.(
These findings support the role of RET in the development of the enteric nervous system but underline the importance of other genetic or environmental factors contributing to the gastrointestinal phenotype of the disease. Somehow, this RET R114H mutation proved to have a role in the etiology of both CIPO and HSCR (show EDNRB Proteins) and could contribute to a more diffuse imbalance of gut (show GUSB Proteins) dysmotility.
High RET expression is associated with perineurial invasion of pancreatic adenocarcinoma.
RET expression was significantly greater in patients with Extraskeletal myxoid chondrosarcoma relative to other types of sarcomas except for liposarcoma
RET gene rearrangement plays a role in the pathogenesis of papillary thyroid cancer.
Patients with high- and moderate-risk RET mutations had similar OS and development of distant metastatic disease after medullary thyroid carcinoma diagnosis and therefore similarly aggressive clinical courses. High-risk connotes increased disease aggressiveness; thus, future guidelines should consider RET mutation classification by disease onset (early vs late) rather than by risk (high vs moderate).
results contradict previous studies suggesting that mammalian GFRalpha1 (show GFRA1 Proteins) and GDNF cannot bind and activate non-mammalian RET and vice versa
The cardiac GFRA2 (show GFRA2 Proteins) signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase (show TYRO3 Proteins).
Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.
Mechanistically, Ret is engaged in a positive feedback loop with Wnt/Wingless signalling, modulated by Src and Fak kinases.
Authors did not find evidence for genetic interaction between Ret and Sema3d (show SEMA3D Proteins) affecting survival, presence of myenteric plexus or intestine transcriptome.
findings uncover a novel spinal circuit that mediates crosstalk between touch and pain pathways and suggest that some early RET positive Dorsal Horn neurons could function as pain "gating" neurons.
Using an organ culture system for prostate development and Ret mutant mice, we demonstrate that RET-mediated GDNF signaling in UGS increases proliferation of mesenchyme cells and suppresses androgen-induced proliferation and differentiation of prostate epithelial cells, inhibiting prostate development.
we described a RET-ER81 (show ETV1 Proteins)-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ
Hox (show MSH2 Proteins) proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes.
Ret and Gfra2 (show GFRA2 Proteins) null mice display comparable early central projection deficits, but Gfra2 (show GFRA2 Proteins) null rapidly adapting mechanoreceptors recover later.
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
proto-oncogene tyrosine-protein kinase receptor Ret
, receptor tyrosine kinase
, ret proto-oncogene
, proto-oncogene tyrosine-protein kinase receptor Ret-like
, RET transforming sequence
, cadherin family member 12
, cadherin-related family member 16
, hydroxyaryl-protein kinase
, proto-oncogene c-Ret
, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
, Ret gene for receptor tyrosin
, Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease)
, ret tyrosine kinase