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anti-Mouse (Murine) RHOG Antibodies:
anti-Rat (Rattus) RHOG Antibodies:
anti-Human RHOG Antibodies:
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Human Polyclonal RHOG Primary Antibody for IHC, IHC (p) - ABIN4350435
Sahu, Kumar, Sreenivasamurthy, Selvan, Madugundu, Yelamanchi, Puttamallesh, Dey, Anil, Srinivasan, Mukherjee, Gowda, Satishchandra, Mahadevan, Pandey, Prasad, Shankar: Host response profile of human brain proteome in toxoplasma encephalitis co-infected with HIV. in Clinical proteomics 2014
ELMO2 (show ELMO2 Antibodies)-RhoG-ILK (show ILK Antibodies) complex has a key role in integrin-independent stabilization of the microtubule network in differentiated keratinocytes.
RhoG is expressed and activated in platelets, plays an important role in GPVI (show GP6 Antibodies)-Fc receptor gamma-chain (show FCER1G Antibodies) complex-mediated platelet activation, and is critical for thrombus formation in vivo.
RhoG protein regulates platelet granule secretion and thrombus formation in mice.
Examined the role of RhoG in the invasive behavior of glioblastoma cells; found that depletion of RhoG strongly inhibits activation of the Rac1 GTPase by both HGF and EGF; also RhoG contributes to the formation of lamellipodia and invadopodia.
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac (show AKT1 Antibodies), CDC42 (show CDC42 Antibodies), and RhoG small GTPase (show RACGAP1 Antibodies) activities
Results indicate that RhoG promotes neural progenitor cell proliferation through PI3K in cortical development.
RhoG function is mediated by signals independent of Rac1 (show RAC1 Antibodies) and Cdc42 (show CDC42 Antibodies) activation and instead by direct utilization of a subset of common effectors
different biological properties of RhoG and Rac1 (show RAC1 Antibodies) can be traced to specific amino acid variations in their switch I, beta2/beta3 hairpin, alpha5 helix, and C-terminal polybasic regions.
In RhoG deficient mice, the development of B and T lymphocytes was unaffected. However, there was an increase in the level of serum IgG1 and IgG2b as well as a mild increase of the humoral immune response to thymus-dependent antigens.
define RhoG as a critical component of G protein-coupled receptor (show GPR34 Antibodies)-stimulated signaling cascades in murine neutrophils
High RHOG expression is associated with lung adenocarcinoma.
RhoG and SGEF (show ARHGEF26 Antibodies) modulate the phosphorylation of paxillin (show PXN Antibodies), which plays a key role during invadopodia disassembly.
yrosine phosphorylation of SGEF (show ARHGEF26 Antibodies) suppresses its interaction with RhoG, the elevation of RhoG activity, and SGEF (show ARHGEF26 Antibodies)-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl (show MCF2 Antibodies) homology domain, as a major phosphorylation site of SGEF (show ARHGEF26 Antibodies) by Src (show SRC Antibodies), and Y530F mutation blocked the inhibitory effect of Src (show SRC Antibodies) on SGEF (show ARHGEF26 Antibodies)
These results suggest that the levels of RhoG and RhoB GTPases and their negative regulator RhoGDI3 might be linked to the aggressiveness of the pancreatic cancerous cell lines. It is possible that RhoGDI3 could induce the downregulation of RhoG and RhoB.
These data suggest a novel link between Tiam1 (show TIAM1 Antibodies) and RhoG/ILK (show ILK Antibodies) /ELMO2 (show ELMO2 Antibodies) pathway as upstream effectors of the Rac1 (show RAC1 Antibodies)-mediated phagocytic process in trabecular meshwork cells.
This study describes the regulation of EMT (show ITK Antibodies) in RPE (show RPE Antibodies) cells by TGF-beta1 (show TGFB1 Antibodies)/miR (show MLXIP Antibodies)-124/RHOG signaling and suggests that the supplement of miR (show MLXIP Antibodies)-124 exogenously would be a valuable therapeutic approach for the prevention or treatment of proliferative vitreoretinopathy.
several Rho family small GTPases activate PI3K (show PIK3CA Antibodies) by an indirect cooperative positive feedback that required a combination of Rac (show AKT1 Antibodies), CDC42 (show CDC42 Antibodies), and RhoG small GTPase (show RACGAP1 Antibodies) activities
The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.
The activation of RhoG recruits its effector ELMO2 (show ELMO2 Antibodies) and a Rac (show AKT1 Antibodies) GEF (show SLC2A4RG Antibodies) Dock4 (show DOCK4 Antibodies) to form a complex with EphA2 (show EPHA2 Antibodies) at the tips of cortactin (show CTTN Antibodies)-rich protrusions in migrating breast cancer cells.
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X.
aplysia ras-related homolog G (RhoG)
, ras homolog G (RhoG)
, rho-related GTP-binding protein RhoG
, sid 10750
, ras homolog gene family, member G (rho G)
, rho G
, ras homolog family member G S homeolog
, ras homolog gene family, member Ga
, ras homolog gene family, member Gd