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findings identify Vegfa as one of a select few known factors sufficient to activate adult cardiomyogenesis, while also illustrating how instructive factors for heart regeneration require spatiotemporal control for efficacy.
Vegfa signaling governs the formation of diverse arteries/veins by distinct cellular mechanisms in vertebrate vasculatures
vascular endothelial growth factor (show VEGF Proteins) and Hedgehog (show SHH Proteins) pathways have roles in the development of the superficial system of ocular vessel patterning in zebrafish
miR (show MYLIP Proteins)-9 modulation of neuronal VEGF-A controls brain angiogenesis in vivo.
Timelapse analysis of individual cardiomyocyte trajectories reveals misdirected cells in zebrafish pdgfra (show PDGFRA Proteins) mutants, suggesting that PDGF (show PDGFA Proteins) signaling steers cardiomyocytes toward the midline during cardiac fusion. Intriguingly, the ligand pdgfaa is expressed in the endoderm medial to the pdgfra (show PDGFRA Proteins)-expressing myocardial precursors.
This study demonstrates the involvement of VEGF signaling in regulating sustained liver injuries after acute alcohol exposure.
we determined that radial glia control this process via the Vegf decoy receptor sFlt1 (show FLT1 Proteins): sflt1 (show FLT1 Proteins) mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 (show FLT1 Proteins) overexpression rescues it. Genetic mosaic analyses show that sFlt1 (show FLT1 Proteins) function in trunk endothelial cells can limit their over-sprouting.
High VEGFA expression is associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.
Rspo1 (show RSPO1 Proteins) is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC (show FUT1 Proteins) specification: Wnt16 (show WNT16 Proteins)/DeltaC/DeltaD and Vegfa/Tgfbeta1 (show TGFB1 Proteins)
Tmem2 (show TMEM2 Proteins) regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.
VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.
sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.
VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.
increased VEGF(170) levels disturb Hand-1 (show HAND1 Proteins) expression in the region required for normal heart morphogenesis
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF (show VEGF Proteins)), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.
Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.
Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).
Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1 (show XBP1 Proteins)/IRE1 alpha (show ERN1 Proteins) and ATF6 (show ATF6 Proteins) arms of the unfolded protein response compared with untreated cells.
Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.
VEGF supports germ cell survival and sperm production in bulls.
analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle
VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter
Alterations in the expression of VEGF-A and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
The data supports the assumption that C9 gene expression may stimulate the expression of inflammatory (NLRP3 (show NLRP3 Proteins)) and angiogenic growth factors (VEGF) in retinal pigment epithelial cells.
DEC2 (show BHLHE41 Proteins) could upregulate retinal VEGF gene expression through modulation of HIF1alpha (show HIF1A Proteins) levels under hypoxic conditions.
High expression of VEGF is associated with Oral Invasive Carcinomas.
High VEGF expression is associated with angiogenesis of esophageal squamous cell carcinoma.
VEGF-A was over-expressed in hypoxic glioblastoma-derived exosomes, which enhance the permeability of a blood-brain barrier in vitro model by interrupting the expression of claudin-5 (show CLDN5 Proteins) and occludin (show OCLN Proteins).
Single CpG methylation appears to enhance VEGF G4 thermostability in a manner dependent on both the CpG methylation site and cation type
shear stress was able to induce arterial endothelial differentiation of stem cells from human exfoliated deciduous teeth, and VEGF-DLL4 (show DLL4 Proteins)/NotchEphrinB2 signaling was involved in this process.
Data indicate that CD147 promotes breast cancer cell proliferation, metastasis, and invasion by modulating matrix metalloproteinase 9 (MMP-9 (show MMP9 Proteins)) and vascular endothelial growth factor (VEGF (show VEGF Proteins)) expression.
Our data demonstrated that the expression of VEGF was significantly related to the tumor incidence, metastasis and prognosis of patients with gastric cancer, which provides new leads to the diagnosis of gastric cancer.
High VEGFA expression is associated with increased lymphangiogenesis and lymph node metastasis in prostate adenocarcinoma.
Study using Hcar1 (show GPR81 Proteins)-KO mice identified the lactate receptor Hcar1 (show GPR81 Proteins) as a key regulator of Vegf and angiogenesis in the brain and as an initial mediator of cerebral effects of physical exercise.
Motor neurons control blood vessel patterning by an autocrine mechanism that titrates motor neuron-derived VEGF via their own expression of sFlt1 (show FLT1 Proteins).
Targeting NLRP3 (show NLRP3 Proteins) shifts the VEGF-A-induced cardiac hypertrophy from a pathologic toward a more physiologic hypertrophy.
T3 thyroid hormone (show PTH Proteins) stimulates the expression and secretion of VEGF by Leydig cells
Dexamethasone suppressed mRNA VEGF expression and VEGF production in cortical cells while in medullar cells only VEGF production was reduced. Introduction of IL-7 (show IL7 Proteins), IL-1b (show IL1B Proteins) or murine thymocytes increased while addition of Semaphorin 3A (show SEMA3A Proteins), SDF-1a or ACTH (show POMC Proteins) decreased VEGF production by cortical epithelial cells with no influence on medullar cells.
lack of endogenous PTH (show PTH Proteins) may reduce VEGF expression in bone marrow mesenchymal stem cellsderived osteoblasts.
Upregulation of podocyte VEGF decreased the number of mesangial cells via inhibition of PDGF-B (show PDGFB Proteins)-mediated signaling.
These data provide a new pathological perspective on cerebellar astrogliosis in Niemann-Pick type C disease and suggest the importance of VEGF as a therapeutic target for this disease.
leukocyte domiciled midkine mediates increased plasma levels of VEGFA relevant for upregulation of endothelial nitric oxide synthase 1 and 3
Mesenchymal stem cells secrete VEGF which in turn mediates the differentiation of endothelial progenitor cells into endothelial cells.
It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.
results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility
Here we demonstrate that VEGF-165 mediates MSC (show MSC Proteins) differentiation into ECs via VEGFR-2 (show KDR Proteins)-dependent induction of Sox18 (show SOX18 Proteins), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.
VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.
VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.
findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch (show NOTCH1 Proteins) signaling.
interleukin-1beta-induced vascular endothelial growth factor (show VEGF Proteins) in airway smooth muscle cells
Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha (show HIF1A Proteins).
data shows that members of the VEGF-VEGFR (show KDR Proteins) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy
cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 (show ANGPT1 Proteins) improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation
Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor (show VEGF Proteins) Secretion
TNF (show TNF Proteins) may up-regulate VEGF and stimulate angiogenesis in the mare (show C16orf35 Proteins) early corpus luteum.
After acoustic trauma, vascular endothelial growth factor (show VEGF Proteins) was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.
Studied the role of T help 17 cells (Th17) and STAT3 (show STAT3 Proteins)-VEGF pathway in pathogenesis of psoriasis.
MiR (show MYLIP Proteins)-145 silencing promotes bone repair of avascular necrosis of femoral head (ANFH (show COL2A1 Proteins)) via upregulating VEGF, bFGF (show FGF2 Proteins) and inhibiting the bone cells apoptosis through Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway
ghrelin (show GHRL Proteins) can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF and VEGFR2 (show KDR Proteins) expression, inhibiting the plaque content of macrophages, and reducing MCP-1 (show CCL2 Proteins) expression at an advanced stage of atherosclerosis in rabbits
VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.
correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV (show KLHL2 Proteins)) and expression of VEGF and MVD (show MVD Proteins) in tumor tissue
Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.
Suggest supplemental oxygen inhibits HIF-1alpha (show HIF1A Proteins)/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 (show MMP9 Proteins) in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
VEGF expression peaked at 8 weeks after meniscus transplantation
Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF (show VEGF Proteins)).
VEGF induces TGF-beta1 (show TGFB1 Proteins) expression and myofibroblast transformation after glaucoma surgery.
Data suggest that microRNA-126 plays role in diabetic retinopathy; here, choroid-retinal endothelial cells exposed to high glucose exhibit down-regulation of microRNA-126 and up-regulation of VEGFA and PIK3R2; overexpression of microRNA-126 down-regulates expression of VEGFA and PIK3R2. (VEGFA = vascular endothelial growth factor A; PIK3R2 = class Ia phosphoinositol-3 kinase regulatory subunit 2 (show CCT2 Proteins))
VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.
These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF, CXCR4 (show CXCR4 Proteins), and TGFB1 (show TGFB1 Proteins) expression and inhibiting choroidl endothelial cell proliferation.
Apelin (show APLN Proteins) may play a role in the development of central retinal vein occlusion (CRVO). Apelin (show APLN Proteins) has a unique upstream signaling pathway, independent of the VEGF pathway.
Dll4 (show DLL4 Proteins) play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha (show HIF1A Proteins) and VEGF during the progression of CNV under hypoxic conditions.
A functional network involving VEGF, IGF2, and MMP9 (show MMP9 Proteins) in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.
, vascular endothelial growth factor A
, vascular endothelial growth factor A-A
, vascular endothelial growth factor A-a
, vascular endothelial growth factor 164
, vascular permeability factor
, vascular endothelial growth factor 188
, angiogenic factor
, Vascular permeability factor
, endothelial growth factor-164
, vascular endothelial growth factor VEGF