Browse our VEGFA Proteins (VEGFA)

Zebrafish Vascular Endothelial Growth Factor A (VEGFA) interaction partners

1. GDF6 promotes vascular stabilization by restraining vascular endothelial growth factor signaling.

2. Vegfaa role in the venous sprouting and spinal cord vascularization.

3. findings identify Vegfa as one of a select few known factors sufficient to activate adult cardiomyogenesis, while also illustrating how instructive factors for heart regeneration require spatiotemporal control for efficacy.

4. Vegfa signaling governs the formation of diverse arteries/veins by distinct cellular mechanisms in vertebrate vasculatures

5. vascular endothelial growth factor and Hedgehog pathways have roles in the development of the superficial system of ocular vessel patterning in zebrafish

6. miR-9 modulation of neuronal VEGF-A controls brain angiogenesis in vivo.

7. Timelapse analysis of individual cardiomyocyte trajectories reveals misdirected cells in zebrafish pdgfra mutants, suggesting that PDGF signaling steers cardiomyocytes toward the midline during cardiac fusion. Intriguingly, the ligand pdgfaa is expressed in the endoderm medial to the pdgfra-expressing myocardial precursors.

8. This study demonstrates the involvement of VEGF signaling in regulating sustained liver injuries after acute alcohol exposure.

9. we determined that radial glia control this process via the Vegf decoy receptor sFlt1: sflt1 mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 overexpression rescues it. Genetic mosaic analyses show that sFlt1 function in trunk endothelial cells can limit their over-sprouting.

10. High VEGFA expression is associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.

11. Rspo1 is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC specification: Wnt16/DeltaC/DeltaD and Vegfa/Tgfbeta1

12. Tmem2 regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.

13. low levels of Vegf signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of Vegf signaling promote arterial and inhibit venous specification.

14. altering the amount of VEGF signaling in endothelial cells by stimulating them with different VEGF concentrations triggered distinct and mutually exclusive dynamic Ca(2+) signaling responses that correlated with different cellular behaviors.

15. Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether downregulate the expression of VEGF and VEGFR, and simultaneously regulates VEGF signaling pathway to prevent angiogenesis.

16. noncanonical function of tars regulates vascular development presumably by modulating the expression of vegfa

17. Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.

18. The translation initiation factor eIF3i up-regulates VEGF-A, accelerates cell proliferation, and promotes angiogenesis in embryonic development.

19. lack of SULF1 expression downregulates VEGFA-mediated arterial marker expression, confirming that Sulf1 mediates arterial specification by regulating VegfA165 activity.

20. yolk-derived 17beta-estradiol sets the ventral boundary of hemogenic vascular niche specification by antagonizing the dorsal-ventral regulatory limits of VEGF.

Xenopus laevis Vascular Endothelial Growth Factor A (VEGFA) interaction partners

1. VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.

2. sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.

3. VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.

4. Functional roles of VEGF122 and VEGF170 during development were examined.

5. increased VEGF(170) levels disturb Hand-1 expression in the region required for normal heart morphogenesis

Cow (Bovine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

1. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

2. Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.

3. Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.

4. Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).

5. Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha and ATF6 arms of the unfolded protein response compared with untreated cells.

6. Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.

7. VEGF supports germ cell survival and sperm production in bulls.

8. analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle

9. VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter

10. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

11. Advanced glycation end products increase, through a protein kinase C-dependent pathway, expression in reignal endothelial cells; inhibited by gliclazide.

12. VEGF signaling is regulated by atrial natriuretic peptide, which preserves endothelial cell tight junction functional morphology

13. Airline pilots are good candidates to see if mutation in the VEGF promoter are responsible for some cases of amyotrophic lateral sclerosis.

14. role in dowregulating Flk-1/KDR involves Cbl-mediated ubiquitination

15. interaction with glucose-6-phosphate dehydrogenase is involved in angiogenesis

16. Results suggest that leptin might elicit angiogenesis through vascular endothelial growth factor induction as well as pigment epithelium-derived factor suppression in pericytes.

17. Shear stress and VEGF converge at the membrane receptor Flk-1 and these stimuli share the Flk-1/Cbl/Akt pathway in activating IKK activation.

18. Tumor cells activate confluent, quiescent EC, promoting survival, phenotypic, and gene expression changes. Of importance, VEGF antagonism converts tumor-conditioned medium from protective to endothelial cell-damaging effects.

19. MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression

20. placenta growth factor expression is regulated by both VEGF and hyperglycaemia via VEGFR-2

Human Vascular Endothelial Growth Factor A (VEGFA) interaction partners

1. miR-944 was significantly downregulated in cancer tissues and cell lines. Upregulating miR-944 inhibited cellular proliferation and invasion in OS cells by directly targeting VEGF.

2. Study shows an increased VEGF-A165a/b ratio in Moyamoya disease compared to intracranial atherosclerotic disease, and suggest that both intensive medical management and surgical revascularization elevate the VEGF-A165a/b ratio in ICAD patients.

3. Parasympathetic activity increases with digital microvascular damage and promotes VEGF release in systemic sclerosis.

4. The expression of COX-2 increase with stage of the endometrial tumor and with the expression of p53 and VEGF in the endometrial carcinomas.

5. VEGF-A expression in ovarian and breast cancer.VEGF-A role in the cancer cell invasiveness.

6. Positive VEGFA cytoplasmic expression was significantly associated with less differentiation grade of oral squamous cell carcinoma.

7. vitreous levels increased in neovascular retinal diseases

8. High expression of VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not of PDGF-BB/PDGFR-beta may contribute to immature and inflammatory intraplaque angiogenesis and plaque instability in a rabbit model of atherosclerosis.

9. GDF6 promotes vascular stabilization by restraining vascular endothelial growth factor signaling.

10. IL-17, a pro-inflammatory cytokine, mostly secreted by infiltrated CD4(+) T helper cells, has shown to mediate resistance to anti-VEGF therapies, through recruiting bone marrow derived cells and modulating stromal cells activities including endothelial cells, tumor associated macrophages and cancer associated fibroblasts. [review]

11. Case Report: protein-losing enteropathy with undifferentiated connective tissue disease with increased intestinal mucosa VEGF.

12. Study shows that both in prostate and breast cancers vascular endothelial growth factor and sphingosine-kinase-1 are independently regulated by mammalian target of rapamycin 1.

13. Findings show that high expression of the angiogenic marker, VEGF, in visceral adipocytes directly promotes vasculature in the uterus and mTOR activity in the endometrial glands, and provide evidence that VEGF-mTOR signaling drives endometrial cell growth leading to hyperplasia and cancer.

14. VEGF, COX-2, and p27 may be important biological markers that determine the angiogenic and lymphangiogenic potentials of papillary thyroid carcinoma, particularly between the follicular and classic variants.

15. VEGF may be associated with the onset of schizophrenia

16. These results not only call into question the use of VEGFA alone in bone regeneration, but also highlight the importance in BTE of appropriately formulated combined delivery of VEGFA and BMP2.

17. VEGF and IL-8 play a prominent role in the pathogenesis of early forms of rosacea and the hemostasis system.

18. The Novel Short Isoform of Securin Stimulates the Expression of Cyclin D3 and Angiogenesis Factors VEGFA and FGF2, but Does Not Affect the Expression of MYC Transcription Factor

19. these results show peripheral blood levels of VEGF are significantly increased in colorectal patients

20. Study found that VEGF-A expression in the epidermis associated to the mechanism of facial reddened skin.

Mouse (Murine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

1. VEGF and VEGFB counteractively regulate adipose development and function in energy metabolism.

2. The data suggest that TFAF6 inhibition reduces choroidal neovascularization formation via down-regulating expression of HIF-1a and VEGF and activation of macrophages and microglia.

3. early local misexpression of VEGF genes and abnormal decidual vasculature preceded sFlt-1 overexpression and increased complement deposition in BPH/5 placentae.

4. Study indicated that Stat3 was involved in the negative regulation of Vegf expression by miR20b in mouse H22 hepatocellular carcinoma cells.

5. Study using Hcar1-KO mice identified the lactate receptor Hcar1 as a key regulator of Vegf and angiogenesis in the brain and as an initial mediator of cerebral effects of physical exercise.

6. Motor neurons control blood vessel patterning by an autocrine mechanism that titrates motor neuron-derived VEGF via their own expression of sFlt1.

7. Targeting NLRP3 shifts the VEGF-A-induced cardiac hypertrophy from a pathologic toward a more physiologic hypertrophy.

8. T3 thyroid hormone stimulates the expression and secretion of VEGF by Leydig cells

9. Dexamethasone suppressed mRNA VEGF expression and VEGF production in cortical cells while in medullar cells only VEGF production was reduced. Introduction of IL-7, IL-1b or murine thymocytes increased while addition of Semaphorin 3A, SDF-1a or ACTH decreased VEGF production by cortical epithelial cells with no influence on medullar cells.

10. lack of endogenous PTH may reduce VEGF expression in bone marrow mesenchymal stem cellsderived osteoblasts.

11. Upregulation of podocyte VEGF decreased the number of mesangial cells via inhibition of PDGF-B-mediated signaling.

12. These data provide a new pathological perspective on cerebellar astrogliosis in Niemann-Pick type C disease and suggest the importance of VEGF as a therapeutic target for this disease.

13. leukocyte domiciled midkine mediates increased plasma levels of VEGFA relevant for upregulation of endothelial nitric oxide synthase 1 and 3

14. Mesenchymal stem cells secrete VEGF which in turn mediates the differentiation of endothelial progenitor cells into endothelial cells.

15. This study showed that the quantity of VEGF in the glioma microenvironment seems to be crucial for the participation of microglia/macrophages on tumor progression.

16. AK131850 directly competed miR-93-5p in N-OC and M-OC through sponge, thereby increasing VEGFa transcription, expression and secretion through derepressing of miR-93-5p on VEGFa.

17. miR203 expression may be upregulated by IL17 stimulation, and miR203 is a positive regulator of IL17induced VEGF secretion.

18. NF-kappaBmiR15abFGF/VEGFA axis contributes to the impaired angiogenic capacity of bone marrowmesenchymal stem cells in high fat dietfed mice.

19. Results support the idea that excess heparin binding epidermal growth factor-like growth factor (HB-EGF) leads to a significant elevation of vascular endothelial growth factor (VEGF) and ventricular dilatation. These data suggest a potential pathophysiological mechanism that elevated HB-EGF can elicit VEGF induction and hydrocephalus.

20. Over-expression of VEGF-A165b is protective against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney.

Pig (Porcine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

1. It regulates endometrial remodeling in the porcine endometrial tissues during follicular and luteal phase.

2. It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.

3. results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility

4. Here we demonstrate that VEGF-165 mediates MSC differentiation into ECs via VEGFR-2-dependent induction of Sox18, which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.

5. VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.

6. VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.

7. findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch signaling.

8. interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells

9. Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha.

10. data shows that members of the VEGF-VEGFR system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy

11. cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation

12. The mRNA for VEGFA was expressed in early developing and in maturing glomeruli.

13. Data show that subventricular zone neural stem cells express VEGF and all VEGF splice variants, VEGFR1, VEGFR2 and Neuropilin-1 and -2 mRNAs.

14. The earlier increase in VEGF protein and mRNA expression in the Meishan versus the Yorkshire conceptus may explain the previously reported increased vascularity and increased placental efficiency of this breed compared the Yorkshire breed.

15. Contrast media did not affect bone marrow cell viability/VEGF secretion.

16. VEGF upregulation in the proliferative zone after ischemic damage may play a role in stimulating vascular invasion and granulation tissue formation in the necrotic hypertrophic zone of the epiphyseal cartilage

17. Data demonstrate that lipopolysaccharides evoke a heat shock response, with an increase heat shock proteins 70 and Hsp32) and of VEGF, a specific endothelial cell growth factor.

18. Vascular endothelial growth factor (VEGF) plays an important role in the thecal angiogenesis during follicular development.

19. number of preovulatory follicles and the capillary density in the theca interna increased significantly in the ovaries injected with VEGF gene

20. our study revealed the presence of VEGF in endothelial and smooth muscle cells of vascular subovarian plexus arteries

Horse (Equine) Vascular Endothelial Growth Factor A (VEGFA) interaction partners

1. Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion

2. TNF may up-regulate VEGF and stimulate angiogenesis in the mare early corpus luteum.

Guinea Pig Vascular Endothelial Growth Factor A (VEGFA) interaction partners

1. After acoustic trauma, vascular endothelial growth factor was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.

2. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

Rabbit Vascular Endothelial Growth Factor A (VEGFA) interaction partners

1. MiR-145 silencing promotes bone repair of avascular necrosis of femoral head (ANFH) via upregulating VEGF, bFGF and inhibiting the bone cells apoptosis through Wnt/beta-catenin pathway

2. ghrelin can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF and VEGFR2 expression, inhibiting the plaque content of macrophages, and reducing MCP-1 expression at an advanced stage of atherosclerosis in rabbits

3. VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.

4. correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV) and expression of VEGF and MVD in tumor tissue

5. Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.

6. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

7. Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.

8. VEGF expression peaked at 8 weeks after meniscus transplantation

9. Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF).

10. VEGF induces TGF-beta1 expression and myofibroblast transformation after glaucoma surgery.

11. The results of this study are promising concerning the role of VEGF as a diagnostic marker in moderate osteoarthritis

12. The overexpression of VEGF increased tumor growth and vascularization, favored cyst formation, and reduced tumor necrosis.

13. VEGF may play a role in the blood-aqueous barrier dysfunction after retinal laser photocoagulation.

14. In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF and TNFalpha.

15. It appears that VEGF modulates angiogenesis and osteogenesis in shockwave-promoted bone healing in rabbits.

16. Transplantation of mononuclear bone marrow cells promotes the expression of VEGF in acute liver injury.

17. The down-regulation of VEGF may play a critical role in the disease process of osteonecrosis.

18. Vitreous VEGF levels increase in positive correlation with plasma VEGF during pregnancy

19. Antenatal intratracheal VEGF administration was associated with an increase in Flk-1 immunoreactivity.

20. VEGF is expressed at different times and locations during bone healing.

Rhesus Monkey Vascular Endothelial Growth Factor A (VEGFA) interaction partners

1. Data suggest that microRNA-126 plays role in diabetic retinopathy; here, choroid-retinal endothelial cells exposed to high glucose exhibit down-regulation of microRNA-126 and up-regulation of VEGFA and PIK3R2; overexpression of microRNA-126 down-regulates expression of VEGFA and PIK3R2. (VEGFA = vascular endothelial growth factor A; PIK3R2 = class Ia phosphoinositol-3 kinase regulatory subunit 2)

2. VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.

3. Evidence of non-AUG translation initiation in humans.

4. Evidence of non-AUG translation initiation in humans.

5. These findings suggest that FBLN5 may interfere with choroidal neovascularization by downregulating VEGF, CXCR4, and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.

6. Apelin may play a role in the development of central retinal vein occlusion (CRVO). Apelin has a unique upstream signaling pathway, independent of the VEGF pathway.

7. Dll4 play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha and VEGF during the progression of CNV under hypoxic conditions.

8. A functional network involving VEGF, IGF2, and MMP9 in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.