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VEGF-B is a potent regulator of the antioxidant pathway in retina.The antioxidant function of VEGF-B is mediated mainly by VEGFR1.
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the expression and role of VEGF-B in diabetic corneal neuropathy was examined by using type 1 diabetic mice and cultured trigeminal ganglion (TG) neurons.
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Data suggest that dietary fatty acids create epigenetic/nutrigenomic changes in methylation levels of CpG island at Vegfb promoter and changes in Vegfb expression in white adipocytes in vivo and in vitro, with particular up-regulation of DNA methylation by linoleic acid; Vegfb promoter methylation levels are closely related to Vegfb gene expression in visceral and subcutaneous adipose tissue.
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renal VEGF-B expression correlates with the severity of Diabetic Kidney Disease.
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PGC-1alpha is a master metabolic sensor that regulates the expression of Vegfa and Vegfb, coordinates blood vessels growth and fatty acid uptake with mitochondrial fatty acid oxidation.
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These data therefore support a tightly controlled, paracrine signaling mechanism of VEGF-B to VEGFR1.
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VEGFB-Induced Vascular Remodeling in Adipose Tissue Requires VEGF/VEGFR2. VEGFB-Induced Vascular Remodeling Improves Insulin Supply, Signaling, and Function in Obese Mice.
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VEGF-B is dispensable for normal cardiac function under unstressed conditions and for high fat diet-induced metabolic changes.
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VEGF-B is a vascular remodeling factor promoting cancer metastasis.
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Data indicate that vascular endothelial growth factor B knockout (Vegf-b-/-) mice showed impaired nerve repair with concomitant impaired trophic function.
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Data indicate that VEGF-B is a high-affinity VEGFR-1 ligand that, unlike PlGF, cannot efficiently induce signaling downstream of VEGFR-1.
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results demonstrate that the vascular endothelium can function as an efficient barrier to excess muscle lipid uptake even under conditions of severe obesity and type 2 diabetes, and that this barrier can be maintained by inhibition of VEGF-B signalling
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the RTEF-1-driven increase of VEGF-B plays an important role in communication between the endothelium and myocardium
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Study indicates that VEGF-B, instead of acting as an angiogenic factor, exerts direct neuroprotective effects through FLT1.
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Data show that no differences in vascular density, perfusion or immune cell infiltration upon altered Vegfb gene dosage were noted.
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VEGF-B appears to be a coronary growth factor in rats but not in mice.
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VEGF-B is involved in the retinal recovery processes and plays a potent role of neuroprotection in retinal ganglion cells after the optic nerve crush.
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VEGF-B specifically controlled endothelial uptake of fatty acids via transcriptional regulation of vascular fatty acid transport proteins
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Assignment of the mouse Vegfb gene to mouse chromosome 19 B
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when overexpressed in the lung, VEGF-B can be as potent as VEGF-A in attenuating pulmonary hypertension, although it has no effect on eNOS expression or vascular permeability.
