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Human VEGFC Protein expressed in Escherichia coli (E. coli) - ABIN413872
Werchau, Toberer, Enk, Dammann, Helmbold: Merkel cell carcinoma induces lymphatic microvessel formation. in Journal of the American Academy of Dermatology 2011
Show all 6 Pubmed References
Vegfc acts through ERK (show MAPK1 Proteins) to induce sprouting and differentiation of trunk lymphatic progenitors.
data not only reveal a non-canonical function of Mt2 (show MT2 Proteins) in angiogenesis, but also propose Mt2 (show MT2 Proteins) as a novel regulator of vegfc expression.
Vegfc signaling increases mafba (show MAFB Proteins) expression to control downstream transcription
Vegfc is dispensable for facial lymphatic sprouting but not for the complete development of the facial lymphatic network.
In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1 (show CCBE1 Proteins), and Vegfc-driven sprouting is enhanced by local Ccbe1 (show CCBE1 Proteins) overexpression. Moreover, Vegfc- and Vegfr3 (show FLT4 Proteins)-dependent Erk (show MAPK1 Proteins) signaling is impaired in the absence of Ccbe1 (show CCBE1 Proteins).
Vegfc has an essential role in lymphangiogenesis [review]
The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 (show FLT4 Proteins) signaling in zebrafish.
Vegfc acts in two distinct modes during development: as a paracrine factor secreted from arteries to guide closely associated lymphatic vasculature and as an autocrine factor to drive migratory persistence during angiogenesis.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
Here, we show that vascular endothelial growth factor C (Vegfc), an angiogenic as well as a lymphangiogenic factor, is unexpectedly involved in this process in zebrafish.
VEGF-C and VEGF (show VEGFA Proteins)-C156S genes have roles in the pro-lymphangiogenic growth factor therapy of lymphedema
Transcription of the vascular endothelial growth factor C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in swine umbilical vein endothelial cells with classical swine fever virus acute infection.
No difference in bioactivity was detected between porcine relaxin-1 (show RLN1 Proteins) and recombinant human relaxin-2 (show RLN1 Proteins) in either mice or rats.
During progressive ischemia, functional and metabolic benefits of intramyocardial VEGF-C gene transfer were apparent. VEGF-C-induced collateral formation occurred at the site of gene transfer
CXCR4 (show CXCR4 Proteins), CCR7 (show CCR7 Proteins), VEGF-C and VEGF-D (show Figf Proteins) expression might have synergistic effects on the lymph node metastasis in patients with cervical cancer.
prolactin induction of VEGF-C and Runx2 was inhibited partly by Carboxypeptidase-D inhibitors, implicating nitric oxide , produced by PRL-regulated Carboxypeptidase-D, in breast cancer progression
Study is the first to describe the mechanism of bFGF (show FGF2 Proteins)-promoted lymphangiogenesis by upregulating VEGF-C expression in chondrosarcomas.
eIF4E (show EIF4E Proteins) promoted cholangiocarcinoma cell metastasis by up-regulating the expression of VEGF-C, MMP-2 (show MMP2 Proteins) and suppressing E-cadherin (show CDH1 Proteins) expression.
High expression of VEGF-C in the primary tumour may be a good determinant for detection of occult tumour cells in the lymph nodes of OSCC cases.
document for the first time that CCL5 (show CCL5 Proteins) induces tumor lymphangiogenesis by the induction of VEGF-C in human cancer cells.
Data suggest that the BRG1 (show SMARCA4 Proteins)/STAT3 (show STAT3 Proteins)/VEGFC in tumor-associated lymphangiogenesis might lead to the discovery of novel therapeutic targets in the treatment of cancers with BRG1 (show SMARCA4 Proteins) loss of function.
Studied the effect of recombinant human vascular endothelial growth factor (VEGF (show VEGF Proteins))-C on lymphangiogenesis, inflammation, and fibrosis in the mouse kidney using the unilateral ureteral obstruction (UUO); lymphangiogenesis was significantly induced in the UUO+VEGF-C group. In lymphatic endothelial cells, VEGF-C increased the activity and proliferation of such cells and expression of VCAM-1 (show VCAM1 Proteins).
In multivariate analysis, only serum VEGF-A (show VEGFA Proteins) correlated to diabetes duration, whereas VEGF-C only correlated to HbA1c and fasting blood glucose.
This study reports that human dendritic cells produce VEGF-C, a cytokine with potent pro-lymphangiogenic activity when stimulated with IFN-gamma (show IFNG Proteins)
lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 (show Adamts2 Proteins) and CCBE1 (show CCBE1 Proteins) spatially and temporally patterns developing lymphatics, and one in which VEGFD (show Figf Proteins) activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth
These results reveal an unexpected role for VEGF-C, a major lymphangiogenic growth factor, in the transition to fetal liver erythropoiesis.
Results suggest that interleukin-6 (IL-6 (show IL6 Proteins)) increases VEGF-C induction and lymphangiogenesis may involve, at least in part, Src (show SRC Proteins)-FAK (show PTK2 Proteins)-STAT3 (show STAT3 Proteins) cascade in lymphatic endothelial cells (LECs).
Data show that heparanase-1 (HPA-1 (show HPSE Proteins)) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (show SDC1 Proteins)) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1 (show SDC1 Proteins)/VEGF-C complex into the medium of hepatocarcinoma cell.
Data show that in the MCF-7 breast cancer cell line, only MT1X (show MT1X Proteins) metallothioneins (MTs (show NEU2 Proteins)) positively correlated with vascular endothelial growth factor C (VEGFC).
The findings in this study strongly suggest the following: i) that VEGF-C promotes the proliferative activity and migratory ability of mesenchymal stem cell ; and ii) VEGF-C and Tgfb (show TGFB1 Proteins) reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes, respectively.
The authors show that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine.
MT1-MMP (show MMP14 Proteins) directly cleaves LYVE-1 (show LYVE1 Proteins) on lymphatic endothelial cells to inhibit LYVE-1 (show LYVE1 Proteins)-mediated lymphangiogenic responses and restrains the production of VEGF-C.
HA increases lymphangiogenesis in renal fibrosis model and also stimulates vascular endothelial cell growth factor (show FGF1 Proteins)-C production from macrophages through Toll-like receptor 4 (show TLR4 Proteins)-dependent signal pathway
Results showed that the VEGF-C/VEGFR-3 (show FLT4 Proteins) system underlies the protective effect of ischemic preconditioning against forebrain ischemia in the mouse hippocampus
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
vascular endothelial growth factor C
, vascular endothelial growth factor c
, FLT4 ligand DHM
, vascular endothelial growth factor-related protein
, flt4 ligand
, vascular endothelial growth factor C isoform 129
, vascular endothelial growth factor C isoform 184