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REVIEW: betaCTX is useful as an adjunct to imaging techniques for the diagnosis of Paget's disease of bone and for monitoring therapy and detecting recurrence. betaCTX also shows promise in the management of metastatic bone disease.
Integrative epigenomics, transcriptomics and proteomics of patients chondrocytes from hip or knee osteoarthritis (OA) identified AQP1, COL1A1 and CLEC3B as significantly and differentially regulated suggesting they play an important role in OA pathogenesis.
ADAMTS-2, collagen type-1, TIMP-3 and papilin levels of the uterosacral ligament play essential roles in the etiopathogenesis of pelvic organ prolapse among postmenopausal women without stress urinary incontinence.
COL1A1 protein and mRNA are upregulated in colorectal cancer tissues and cells regardless of KRAS genotype.
Serum was analyzed for sclerostin, cross linked telopeptide of type I collagen (CTXI), and procollagen type I amino-terminal propeptide (PINP). A significant time effect was found for sclerostin, which increased from pre-exercise to 5 min after exercise in both trials
The Col1A1 Sp1-binding site gene polymorphism showed a significant association in ALL patients with osteonecrosis.
Study identified COL1A1 gene as an invasionrelated gene from bioinformatics analysis. Its high level expression in malignant astrocytoma (MA) suggests that COL1A1 may be a candidate biomarker for MA prognosis.
The majority of the identified P/LP variants were in the FBN1 gene ..we found 4.9% of patients carried a P/LP variant as the underlying cause of their Thoracic aortic aneurysm/aortic dissection (TAAD), predominantly within FBN1 but with substantial contributions from TGFBR and COL genes.
a COL1A1 signal peptide heterozygous mutation leading to severe osteogenesis imperfecta
CITP, PIIINP, and P4NP 7S do not reflect myocardial collagen mRNA expression but presumably reflect extra-cardiac organ injury in heart failure.
BCL2, CCND1 and COL1A1 may be key novel clinically relevant genes in papillary thyroid carcinoma.
the presence or absence of a single cysteine in type-I collagen's C-propeptide domain is a key factor governing the ability of a given collagen polypeptide to stably homotrimerize.
Associated trait of genotype TT of polymorphisms of COL1A1gene rs 1800012 involves dolichostenomelia, joints' hypermobility, frequency increase of back bone deflection and rising CT exhaustion level in dysplastic process that is corresponded with abnormality of connective tissue skeleton qualitative composition
results strengthen the evidence for the association between polymorphisms of -1997 G/T, +1245 G/T of the COL1A1 gene in the genetic etiology of keloid scars
Structural basis of homo- and heterotrimerization of COL1A1/ COL1A2 has been reported.
patients with OI have homogenously thinner corneas compared with controls, we observed that a collagen I chain mutation was not responsible for corneal curvature alterations in OI.
Our findings demonstrate that collagen I could enhance the aggressive progression of residual hepatocellular carcinoma cells after suboptimal heat treatment and sorafenib may be a treatment approach to thwart this process.
Cellular expression of COL1A1 could promote breast cancer metastasis. COL1A1 is a new prognostic biomarker and a potential therapeutic target for breast cancer, especially in ER+ patients.
miR-129-5p level was decreased in fibrotic liver of human, and reduced by rOPN treatment. In contrast, miR-129-5p was induced in HSCs transfected by OPN siRNA. These data suggested that OPN induces Col 1 expression via suppression of miR-129-5p in hepatic stellate cells.
Depletion of MRTF-A abolished the upregulation of COL1A1 in response to the TGF-beta or Wnt signaling.
Partial fructosyl-hydroxylysine glycations at each of the helical domain cross-linking sites of type I collagen are found that are elevated in tissues from a diabetic mouse model.
Results show that COL1A1 and COL3A1 expression is up-regulated in Schistosoma japonicum-induced liver fibrosis. Furthermore, miR-29b directly targets COL1A1 and COL3A1 through binding to their 3'UTR.
findings suggest that deficiencies of leucine and isoleucine reduce type I and III tropocollagen syntheses in skin by suppressing the action of mTOR
Our studies demonstrate that a collagen-I-dense ECM can potently alter hormonal signals to drive the progression of ERalpha + breast cancer, increasing intravasation and pulmonary metastases.
Offspring that inherited the osteogenesis imperfect (OI) and high bone mass alleles had higher bone mass and strength than mice that inherited the OI allele alone.
a surface population of Hsp90 extracellularly binds TGFbetaRI and this complex behaves as an active participant in collagen production in TGFbeta-activated fibroblasts.
osthole could inhibit the collagen I and III expressions and their ratio in CFs treated with TGF-beta1 via Smad signaling pathway, which might be one of its anti-fibrotic action mechanisms.
Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA, and COL1a1 expression in a liver fibrosis disease model.
Type I collagen was highly expressed in the spinal cord during the scar-forming phase and induced astrocytic scar formation via the integrin-N-cadherin pathway.
collagen-I-mediated inhibition of proplatelet formation is specifically controlled by GPVI.
miR-29b can reduce collagen biosynthesis during skin wound healing likely via post-transcriptional inhibition of HSP47 expression.
Col1a1Jrt/+ mutant mice produce craniofacial and dental defects consistent with osteogenesis imperfecta and Ehlers-Danlos syndrome
the rate of collagen I degradation was increased in Poldip2(+/-) vs. Poldip2(+/+) MASMs. Conversely, activation of the PI3K/Akt/mTOR signaling pathway, involved in regulation of protein synthesis, was significantly elevated in Poldip2(+/-) MASMs as was beta1-integrin expression.
These data provided a plausible mechanism linking maternal vitamin D deficiency with altered postnatal lung function.
Col1 expression was seen in the cartilage zone of the mandibular condyle cartilage.
the Col1a1Jrt/+ mouse model of severe OI has hypersensitivity to mechanical and thermal stimuli, consistent with a state of chronic pain
HRG binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.
Calreticulin in mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation.
Homocysteine Induces Collagen I Expression by Downregulating Histone Methyltransferase G9a
These data suggested that intestinal epithelial cells were injured after IM treatment through the pVHL overexpression-induced degradation of collagen I or HIF-1alpha.
The present findings suggest that prolyl 3-hydroxylation incrementally regulates collagen fibril diameter in tendon.
These observations support a signaling network among JNKs, Smads, Snail1, and cortactin to regulate the invasion of MDA-MB-231 cells embedded in 3D collagen I, which may be targeted during screening of anti-invasion reagents.
The experiment results demonstrated that the aggregates of collagen incurred in the range of 0.30-0.45 mg/mL, while the more complicated ones emerged at higher concentrations of collagen (0.75 and 1.05 mg/mL).
Two subsystems of meniscal collagen and their different thermal stabilities.
These results imply that the fibril form of collagen plays a potential role in inhibiting the growth of cancer cells.
Data show that biglycan, collagen type I, collagen type II, decorin, and versican were significantly affected by vibration duration, frequency, and amplitude.
specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V
In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen
These results demonstrate a novel and important functional role of the DDR2 extracellular domain that may contribute to collagen regulation via modulation of fibrillogenesis.
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
A molecular model of collagen hydration is used to validate centrifugal dehydration force (CDF) and re-hydration isotherm (RHI) methods to measure and characterize hydration compartments on bovine tendon.
The elastic fibers are under tension and impart an intrinsic compressive stress on the collagen.
skeletal maturity may influence anterior cruciate ligament cells' metabolic activity, apoptosis, collagen production, and response to platelet rich plasms.
type I collagen degradation occurs within minutes after myocardial infarction
ven though in adult bone, skin and scales equal amounts of a1(col1a1a) a2(col1a2) and a3(col1a2)chains are present, the presented data suggest a tissue-specific stoichiometry and/or post-translational modification status for collagen type I
heterozygous chihuahua fish have phenotypic similarities to human osteogenesis imperfecta; mapping and molecular characterization of the chihuahua mutation indicates that the defect resides in the gene encoding the collagen I(alpha1) chain
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
alpha-1 type I collagen
, collagen alpha 1 chain type I
, collagen alpha-1(I) chain
, collagen alpha-1(I) chain preproprotein
, collagen of skin, tendon and bone, alpha-1 chain
, pro-alpha-1 collagen type 1
, alpha-1 type 1 collagen
, procollagen, type I, alpha 1
, collagen, type 1, alpha 1
, procollagen type I, alpha 1
, procollagen, type 1, alpha 1
, collagen, type I, alpha 1
, type I collagen alpha 1 chain
, type I collagen alpha1
, type I collagen pre-pro-alpha1(I) chain
, alpha 1 type I collagen
, collagen, type I, alpha 2
, collagen type I alpha 1
, prepro-alpha-1 collagen type I
, procollagen alpha 1 (I)
, collagen 1a1
, pro-alpha-1 type 1 collagen
, alpha-1 collagen (I)
, collagen alpha-1 chain
, collagen, type I, alpha 1b
, collagen, type I, alpha 3