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miR378b represses the mRNA expression levels of COL1A1 via interference with SIRT6 (show SIRT6 Proteins) in human dermal fibroblasts.
Exogenous proline stimulates type I collagen and HIF-1alpha expression and the process is attenuated by glutamine in human skin fibroblasts.
the efficacy of pamidronate treatment does not seem to be related to the genotype of type I collagen in patients with osteogenesis imperfecta (show COL1A2 Proteins).
MiR (show MLXIP Proteins)-133a-3p could inhibit the proliferation and migration of oral squamous cell carcinoma cells through directly targeting COL1A1 and reducing its expression.
COL1A1 gene mutation is associated with osteogenesis imperfecta (show COL1A2 Proteins).
Elevation of serum alpha1(I) collagen DNA levels in scleroderma patients may be useful as the diagnostic marker, reflecting the presence of vasculopathy.
study showed that GG homozygotes were underrepresented in the ACL (show ACLY Proteins)-rupture group compared with the control group, which suggests an association with reduced risk of anterior cruciate ligament injury
Review/Meta-analysis: possible relationship between GG genotype of COL1A1 +1245G/T polymorphism and osteoporosis risk in post-menopausal women.
These results support an activation mechanism of DDR1 (show DDR1 Proteins) whereby collagen induces lateral association of DDR1 (show DDR1 Proteins) dimers and phosphorylation between dimers.
an endoplasmic reticulum complex of resident chaperones that includes HSP47 (show SERPINH1 Proteins), FKBP65 (show FKBP10 Proteins), and BiP (show GDF10 Proteins) regulating the activity of LH2 (show PLOD2 Proteins).
Our studies demonstrate that a collagen-I-dense ECM (show MMRN1 Proteins) can potently alter hormonal signals to drive the progression of ERalpha (show ESR1 Proteins) + breast cancer, increasing intravasation and pulmonary metastases.
a surface population of Hsp90 (show HSP90 Proteins) extracellularly binds TGFbetaRI and this complex behaves as an active participant in collagen production in TGFbeta (show TGFB1 Proteins)-activated fibroblasts.
osthole could inhibit the collagen I and III expressions and their ratio in CFs treated with TGF-beta1 (show TGFB1 Proteins) via Smad (show SMAD1 Proteins) signaling pathway, which might be one of its anti-fibrotic action mechanisms.
Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA (show SMN1 Proteins), and COL1a1 expression in a liver fibrosis disease model.
Type I collagen was highly expressed in the spinal cord during the scar-forming phase and induced astrocytic scar formation via the integrin-N-cadherin (show CDH2 Proteins) pathway.
collagen-I-mediated inhibition of proplatelet formation is specifically controlled by GPVI (show GP6 Proteins).
miR (show MLXIP Proteins)-29b can reduce collagen biosynthesis during skin wound healing likely via post-transcriptional inhibition of HSP47 (show SERPINH1 Proteins) expression.
Col1a1Jrt/+ mutant mice produce craniofacial and dental defects consistent with osteogenesis imperfecta (show COL1A2 Proteins) and Ehlers-Danlos syndrome
the rate of collagen I degradation was increased in Poldip2 (show POLDIP2 Proteins)(+/-) vs. Poldip2 (show POLDIP2 Proteins)(+/+) MASMs. Conversely, activation of the PI3K/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway, involved in regulation of protein synthesis, was significantly elevated in Poldip2 (show POLDIP2 Proteins)(+/-) MASMs as was beta1-integrin expression.
Col1 expression was seen in the cartilage zone of the mandibular condyle cartilage.
These observations support a signaling network among JNKs, Smads, Snail1 (show SNAI1 Proteins), and cortactin (show CTTN Proteins) to regulate the invasion of MDA-MB-231 cells embedded in 3D collagen I, which may be targeted during screening of anti-invasion reagents.
Data show that biglycan (show BGN Proteins), collagen type I, collagen type II, decorin (show DCN Proteins), and versican (show Vcan Proteins) were significantly affected by vibration duration, frequency, and amplitude.
specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V
In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen (show COL1A2 Proteins)
These results demonstrate a novel and important functional role of the DDR2 (show DDR2 Proteins) extracellular domain that may contribute to collagen regulation via modulation of fibrillogenesis.
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
A molecular model of collagen hydration is used to validate centrifugal dehydration force (CDF (show CTNNA2 Proteins)) and re-hydration isotherm (RHI) methods to measure and characterize hydration compartments on bovine tendon.
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
collagen, type I, alpha 1
, alpha 1 type I collagen
, collagen, type I, alpha 2
, collagen type I alpha 1
, procollagen alpha 1 (I)
, collagen 1a1
, alpha-1 type I collagen
, collagen alpha 1 chain type I
, collagen alpha-1(I) chain
, collagen alpha-1(I) chain preproprotein
, collagen of skin, tendon and bone, alpha-1 chain
, pro-alpha-1 collagen type 1
, alpha-1 type 1 collagen
, procollagen, type I, alpha 1
, alpha-1 collagen (I)
, collagen alpha-1 chain
, type I collagen pre-pro-alpha1(I) chain
, prepro-alpha-1 collagen type I
, type I collagen alpha 1 chain
, type I collagen alpha1
, pro-alpha-1 type 1 collagen
, collagen, type 1, alpha 1
, procollagen type I, alpha 1
, procollagen, type 1, alpha 1