COL4a3 ELISA Kit

Antigen Summary

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

Alternative names and synonyms associated with COL4a3

• collagen type IV alpha 3 chain (COL4A3) ELISA Kit
• collagen, type IV, alpha 3 (col4a3) ELISA Kit
• collagen, type IV, alpha 3 (Col4a3) ELISA Kit
• collagen type IV alpha 3 chain (Col4a3) ELISA Kit

• zTumstatin ELISA Kit
• [a]3(IV) ELISA Kit
• alpha3(IV) ELISA Kit

Protein level used designations for COL4a3

type IV collagen alpha 3 chain , collagen alpha-3(IV) chain , collagen type IV alpha3 chain , procollagen, type IV, alpha 3 , tumstatin , collagen, type IV, alpha 3 (Goodpasture antigen) , collagen IV, alpha-3 polypeptide