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anti-Rat (Rattus) GABRA5 Antibodies:
anti-Human GABRA5 Antibodies:
anti-Mouse (Murine) GABRA5 Antibodies:
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Mouse (Murine) Polyclonal GABRA5 Primary Antibody for WB - ABIN152536
Maison, Rosahl, Homanics, Liberman: Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Show all 5 Pubmed References
GABRA5 receptor plays a unique role in reinforcing the effects of alcohol.
evaluated the role of alpha1 and alpha5 subunit-containing GABAA (show GABRg1 Antibodies) receptors (alpha1GABAA and alpha5GABAA receptors, respectively) in the ability of benzodiazepine-type drugs to alter performance in the cognitive domain of executive function
Low GABRA5 expression typified hyperproliferative tumors, and loss of taurine signaling correlated with reduced patient survival, suggesting this tumor suppressive mechanism operates in vivo.
Report benzodiazepine derivative as GABA-site inhibitor of extra-synaptic GABAA (show GABRg1 Antibodies) alpha5 receptors.
Study found that a significant portion of GABAergic postsynaptic compartments contain the alpha5 GABAAR (show GABRG2 Antibodies) subunit, both in vitro and in vivo
This study showed that in male groups, the expression of GABRA5 was generally lower in schizophrenia cases compared to the control.
Findings provide genetic evidence for the involvement of the genes GABRB3 (show GABRB3 Antibodies) and GABRA5 in the susceptibility to panic disorder
1,2-dichlorohexafluorocyclobutane enhancement of GABRA5 activity is abolished by GABRB3 (show GABRB3 Antibodies) mutations.
These results provide initial evidence of a GABAA (show GABRg1 Antibodies) alpha5 deficit in autism spectrum disorder and support further investigations of the GABA system in this disorder.
The ratios of beta(3)/beta(2) and alpha(5)/alpha(1) subunit protein expression in Angelman syndrome (show ube3a Antibodies) cortex were significantly decreased when compared with controls.
These results suggest that the GABRA5 gene may confer susceptibility to bipolar I disorder.
findings support the hypothesis that reduced alpha5GABAAR activity contributes to an Autism Spectrum Disorder phenotype. The results also suggest that Gabra5-/- mice may serve as an animal model for ASD (show GUSB Antibodies), as assessed through EEG activity and sleep-wake behaviors.
Deletion of Gabra5 in newborn granule cells caused severe alterations of migration and dendrite development.
This study demonstrated that alpha5-GABAAR (show GABRG2 Antibodies)-mediated tonic inhibition in the DG plays an important role in ensuring normal cognitive functioning under high-interference memory conditions.
The results of this study suggested that gabra5 mediated tonic current, which is potentiated by H2O2, might contribute to H2O2-induced brain dysfunction.
in mice that lack the alpha5 subunit gene (Gabra5-/-), cultured embryonic hippocampal pyramidal neurons and ex vivo CA1 (show CA1 Antibodies) hippocampal neurons unexpectedly exhibited a decrease in Ih current density
Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide.
Data suggest that chronic exposure to ketamine impairs working memory in mice, which may be explained at least partly by up-regulation of Gabra5 subunits in the prefrontal cortex.
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
gamma-aminobutyric acid (GABA) A receptor, alpha 5
, gamma-aminobutyric acid A receptor, alpha 5-like
, gamma-aminobutyric acid receptor subunit alpha-5-like
, GABA(A) receptor subunit alpha-5
, GABA-A receptor alpha-5 subunit
, gamma-aminobutyric acid A receptor, alpha 5
, gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5
, gamma-aminobutyric acid A receptor, alpha 5
, gamma-aminobutyric acid receptor subunit alpha-5
, GABAA receptor alpha5 subunit
, ligand-gated ion channel subunit