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Human Monoclonal GJB3 Primary Antibody for IF, ELISA - ABIN561044
Tattersall, Scott, Gray, Zicha, Kelsell: EKV mutant connexin 31 associated cell death is mediated by ER stress. in Human molecular genetics 2009
Prostaglandin E stimulates Connexin isoforms via GSK-3beta/beta-catenin (show CTNNB1 Antibodies) via EP2-receptor-dependent cAMP/PKA and PI3K/Akt (show AKT1 Antibodies) in mouse embryonic stem cells.
Connexin 31-deficient trophoblast stem cells revealed a shift in giant cell differentiation from Prl3d1 expressing parietal giant cells to Ctsq, Prl3b1, and Prl2c2-positive giant cells.
Expression profile of the Gjb3 in the developing mouse cochlea
Mutant cx31 showed reduced phosphorylation levels compared to Cx31 wild type, indicating a pivotal role of serine residue 266 for Cx31 phosphorylation, but didn't interfere with correct intracellular trafficking of gap junction proteins.
During trophoblast cell lineage differentiation, the Cx31 gap junction channel is involved in maintaining the proliferative diploid trophoblast cell population.
Cx31/Cx43 (show GJA1 Antibodies) double-deficient mice exhibit the known phenotypes of the single-knockout strains but no combined effects
Cx31 and Cx43 (show GJA1 Antibodies) proteins functionally interact, possibly by forming heteromeric channels in the epidermis.
GJB3 c.538C>T does not contribute to hearing loss, and this conclusion will assist with genetic counseling and risk prediction for deafness related to the GJB3 c.538C>T variant
The results of the present study indicated that combined heterozygous mutations of the SLC264 and GJB3 genes may result in severe hearing loss. These results contribute to the understanding of clinical phenotype of deaf patients carrying combined mutations in the SLC26A4 (show SLC26A4 Antibodies) and GJB3 genes.
study suggests that Connexin-31 mutant proteins are un/misfolded to cause erythrokeratodermia variabilis likely via an AP-1 (show FOSB Antibodies)-mediated mechanism and identifies a small molecule with therapeutic potential of the disease
identified dominant pathogenic missense mutation in the M4 transmembrane domain of GJB3; mutation led to the erythrokeratodermia variabilis (EKV) phenotype in the patient's family; results, combined with literature review, suggest dominant missense mutations outside the E2 domain in GJB3 are associated with EKV, and those within the E2 domain cause ADNSHL
Mutations in 12S rRNA, SLC26A4 (show SLC26A4 Antibodies), GJB2 (show GJB2 Antibodies) and GJB3 are highly associated with deafness.
The CX31 V174M mutant may have an effect on the formation and function of the gap junction, in nonsyndromic hearing loss.
In this study, we found no mutations of GJB3 in two Progressive symmetrical erythrokeratoderma families.
We report a missense mutation p.G45E in the GJB3 gene, which was responsible for Erythrokeratodermia variabilis in a Chinese family.
GJB3 and GJB6 (show GJB6 Antibodies) genetic variants are associated with the pathogenicity of nonsyndromic sensorineural hearing loss.
Mutation analysis of GJB3 and GJB4 (show GJB4 Antibodies) in Chinese patients with erythrokeratodermia variabilis.
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
connexin 31 b
, connexin 31
, gap junction protein, beta 3 b
, gap junction protein, beta 3, 31kDa
, gap junction beta-3 protein
, gap junction membrane channel protein beta 3
, gap junction beta 3
, gap junction beta-6 protein
, gap junction protein, beta 6 (connexin 30)