Connexin 31 antibody (C-Term)

Catalog No. ABIN5536021

Product Details anti-Connexin 31 Antibody

Target: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Binding Specificity: AA 227-257, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Connexin 31 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This Connexin 31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-257 amino acids from the C-terminal region of human Connexin 31.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Connexin 31

Target: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Alternative Name: Connexin 31 (GJB3 Products)

Synonyms: CX31 antibody, DFNA2 antibody, DFNA2B antibody, EKV antibody, Cnx31 antibody, Cx31 antibody, D4Wsu144e antibody, Gjb-3 antibody, ekv antibody, cx31 antibody, dfna2 antibody, gjb3b antibody, dfna2b antibody, connexin-31 antibody, gap junction protein beta 3 antibody, gap junction protein, beta 3 antibody, gap junction protein beta 3 L homeolog antibody, GJB3 antibody, Gjb3 antibody, gjb3.L antibody, gjb3 antibody

Background: Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

Molecular Weight: 31 kDa

Gene ID: 2707

UniProt: O75712

Pathways: Sensory Perception of Sound