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We found a significant reduction of testosterone levels in mGluR7 knockout (KO) mice. Social investigating behaviour of intact mGluR7 KO mice also differed from that of wild-type mice; e.g. the KO mice showing less frequent anogenital sniffing and more frequent grooming behaviour. Further, castrated mGluR7 KO mice have smaller seminal vesicles than those of castrated wild-type mice, although intact mice were no different.
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Altered mGlu7 expression was found in brain regions associated with fear extinction in two different mouse strains which differ in their fear extinction behavior.
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mGlu7 may be a potential therapeutic target for multiple aspects of the Rett phenotype.
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The mGlu7 receptor was found to be involved in a wide range of behavioral and physiological alterations in response to chronic psychosocial stress exposure.
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This study provides evidence for mGlu7 receptor-mediated tonic modulation of a physiological function in vivo preventing synchronous and potentially pathological oscillations.
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Analysis of mGluR7 KO mice, c-Fos expression, and cerebral MMPIP microinjection indicate that inhibition of mGluR7 impairs intermale aggression owing to information processing dysfunction within the bed nucleus of the stria terminalis
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muscle does not appear to require high levels of SMN above what is produced by two copies of SMN2
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SAM68 is a physiological regulator of SMN2 splicing in a spinal muscular atrophy mouse model.
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Hyperoxia treatment increased the inclusion of SMN2 exon 7 in skeletal muscles and resulted in improved motor function.
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Elfn1 recruits mGluR7 to synaptic sites.A trans interaction of Elfn1 and mGluR7 controls targeted interneuron synapse development.
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GRM7 regulates the phosphorylation of CREB protein and the expression of Yes-associated protein (YAP) by directly interacting with CaM, which subsequently regulates the expression of CyclinD1 and ultimately affects early cortical development.
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Modeling the selective interaction between XAP044 and mGlu7's Venus flytrap domain, whose three-dimensional structure is already known, will facilitate future drug development supported by computer-assisted drug design
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The data of this study revealed very different roles for mGlu7 in amygdala synaptic transmission, fear learning and its expression
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These data suggest targeting mGlu7 receptors with selective antagonist drugs may be an effective and safe strategy for the treatment of anxiety disorders.
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Glutamate release mediated by GluR7 at nerve terminals is influenced by divalent calcium channel type Ca2+ ionophore.
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mGluR7, by affecting the cofilin/actin signaling, regulates NMDAR trafficking and function
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The genomic integration site of the mGluR7 transgene is in intron 4 in spinal muscular atrophy transgenic mice, especially those that have extended survival.
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Phorbol esters and prolonged activation of mGlu7 receptors both potentiate glutamate release via a common intracellular signalling pathway that occurs in nerve terminals containing N-type divalent calcium channels.
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This study suggested that mGlu7 receptor is involved in the regulation of GABAergic system activity at the level of GABA synthesised enzymes, specific proteins expressed by GABAergic neurons and metabotropic receptor for GABA.
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mGlu7 receptors may not only regulate the central components of chronic stress, but may also have a role in the regulation of fluid & electrolyte transport which is significantly disrupted in diseases such as IBS, by enhancing colonic secretory activity