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Human Monoclonal PAX3 Primary Antibody for CyTOF, FACS - ABIN4898992
Awaya, Kato, Mizuno, Chang, Niwa, Umeda, Nakahata, Heike: Selective development of myogenic mesenchymal cells from human embryonic and induced pluripotent stem cells. in PLoS ONE 2012
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Human Polyclonal PAX3 Primary Antibody for IF (p), IHC (p) - ABIN737616
Bonchak, Eby, Willenborg, Chrobak, Henning, Krzywiec, Johnson, Le Poole: Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin. in Archives of biochemistry and biophysics 2014
Show all 4 Pubmed References
Human Polyclonal PAX3 Primary Antibody for IHC (p), IHC - ABIN250216
Hsieh, Yao, Lai, Yang: Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1. in Biochemical and biophysical research communications 2006
Show all 2 Pubmed References
Human Polyclonal PAX3 Primary Antibody for IHC, ELISA - ABIN185216
Tsukamoto, Nakamura, Niikawa: Isolation of two isoforms of the PAX3 gene transcripts and their tissue-specific alternative expression in human adult tissues. in Human genetics 1994
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Human Monoclonal PAX3 Primary Antibody for ELISA, WB - ABIN1724816
Dong, Li, Cao, Liu, Pier, Chen, Xu, Chen, Wang, Cui: FGF2 regulates melanocytes viability through the STAT3-transactivated PAX3 transcription. in Cell death and differentiation 2012
Human Polyclonal PAX3 Primary Antibody for IF/ICC, WB - ABIN2990115
Cao, Du, Lv, Lin, Mao, Xu, Liu, Liu: PAX3 inhibits β-Tubulin-III expression and neuronal differentiation of neural stem cell. in Biochemical and biophysical research communications 2017
Pax3 and SB1 gene interact to create different coat color patterns
No significant associations with coat color were found for PAX3 variants
A novel missense variant, PAX3:p.Pro32Arg, in Appaloosa horses with a splashed white phenotype in addition to their leopard complex spotting patterns.
several independent mutations in MITF and PAX3 together with known variants in the EDNRB and KIT genes explain a large proportion of horses with the more extreme white spotting phenotypes
The pax3 and Pax7 paralogs cooperate in neural and neural crest patterning using distinct molecular mechanisms, in Xenopus laevis embryos.
the inhibition of Alveolar rhabdomyosarcoma cell proliferation, survival, and migration after knockdown of PAX3-FOXO1 was significantly (>75%) reversed by knockdown of IL24.
Immunohistochemical expression of PAX3 is highly sensitive and specific for biphenotypic sinonasal sarcoma.
Results found that hypermethylation of Pax3 and the downregulation of the gene may be important events in the development of neural tube defects (NTDs) during embryogenesis. Also, a relationship was found between higher maternal serum PAH concentrations and PAX3 hypermethylation in fetal neural tissues with tube defects.
The HOXD8/DIAPH2-AS1 network regulated HTR-8/SVneo cell function under hypoxia by epigenetically regulating PAX3. This regulatory network may thus be responsible for PAX3 down-regulation in the placentas of PE patients.
PAX3 promotes glioma growth and development, by interacting with beta-catenin and regulating the Wnt signaling pathway.
Overexpression of miR-1 suppressed cell proliferation and induced arrest in the G0/G1 phase by increasing p21 levels via a p53-independent pathway through PAX3 suppression. These results indicate that miR-1 could be a therapeutic target for osteosarcoma.
PAX3-FOXO1 regulates key microRNAs that may represent novel therapeutic vulnerabilities in fusion positive Rabdomyosarcomas.
miR-206 reduces osteosarcoma cell malignancy in vitro by targeting PAX3 and MET gene expression.
In this review, we will discuss the current knowledge regarding potential therapeutic targets that might contribute to indirect interference with PAX3-FOXO1 activity in alveolar rhabdomyosarcoma at the different molecular levels and extrapolate these findings to fusion transcription factors in general.
Results shows that GILT expression is required for downregulation of PAX-3 proteins in late stage human melanoma cells. GILT co-localizes with PAX-3 proteins regulating its expression through the autophagy and lysosomal degradation pathway in human melanoma cells.
Results demonstrate that serum level of miR-658 is significantly lower in the NM group than in the DM group. Meanwhile, the levels of PAX3 and MET are lower in the NM group than in the DM group too. Both overexpression and silence of miR-658 significantly up-regulate or down-regulate the levels of PAX3 and MET in gastric cell lines.
miR-362-3p/Pax3 axis regulates cell viability, migration and invasion of HTR8/SVneo cells under hypoxia.
In spinal cord tissue, lower PAX3 expression, higher p53 expression, and increased levels of cleaved caspase 3(17kD) and cleaved caspase 8 (18kD) were found in anencephaly cases but not in spina bifida cases when compared with controls.
PAX3 has a major regulatory role in the development, maintenance and progression of certain tumors, which may be related to its role in normal development. [review]
PAX3-FOXO1 fusion protein serves as a driver mutation to initiate a cascade of mRNA and miRNA changes that ultimately reprogram proliferating myoblasts to induce the formation of alveolar rhabdomyosarcoma
Cells harboring the fusion gene are selectively sensitive to small-molecule inhibition of protein targets induced by, or bound to, PAX3-FOXO1-occupied super enhancers. Furthermore, PAX3-FOXO1 recruits and requires the BET bromodomain protein BRD4 to function at super enhancers, resulting in a complete dependence on BRD4 and a significant susceptibility to BRD inhibition
The borders of this novel topologically associating domains (TADs)correspond to the original 5'- and 3'- borders of the PAX3 and FOXO1 TADs, respectively, suggesting that TAD organisation precedes the formation of regulatory long-range interactions. Our results demonstrate that, upon translocation, novel regulatory landscapes are formed allowing new intra-TAD interactions between the original loci involved
identified novel EYA4 mutation can be considered responsible of the hearing loss observed in the proband and her father, while a dual molecular diagnosis was reached in the relatives co-segregating the EYA4 and the PAX3 mutations
Transcriptional factor PAX3 (PAX3) exerted its tumor suppressor function by inhibiting the activity of major signaling pathways and enhancing expression and activity of transcription factor forkhead box O3 protein (FOXO3a).
These previously unreported digenic mutations in PAX3/GJB2 resulted in deafness associated with Waardenburg syndrome type I in this family
SNP and haplotype analysis of PAX3 gene provide evidence for association with growth traits in Chinese cattle.
Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mouse mesoderm.
Hippo/MST downregulation has a critical role in PAX3-FOXO1-positive rhabdomyosarcoma tumorigenesis
Study identifies Pax3 interaction with members of the chromatin looping complex, including the LIM-domain binding protein 1 (Ldb1) and demonstrates that Ldb1 is recruited to a subset of Pax3-bound elements characterized by increased levels of H3K4me1 deposition. Reduced Ldb1 expression impairs Pax3-dependent myogenic specification both in vitro and in vivo.
MIR-124 suppresses PAX3 expression, which in turn regulated the differentiation of neural stem cells.
Zac1 and GPR39 are upregulated by Pax7 but not Pax3. Pax3 plays a different role in myogenic progression than Pax7.
Mass spectrometry based screening for potential interaction partners revealed that BRAF interacts and phosphorylates PAX3.
Sequence analysis identified a missense point mutation (c.101G>A) in exon 2 of Pax3 that resulted in a methionine to isoleucine conversion at amino acid 62 of the PAX3 protein
This study show that Pax3+ satellite cells retain long-term self-renewal ability and express slow-MyHC isoforms after differentiation.
Pax3 enhances expression of Polysialic acid on neural cell adhesion molecule in NMuMG cells by upregulating ST8Sia II expression and downregulating ST8Sia IV expression.
PAX3 role in neural tube defects
The Pax3(GFP) allele proved to be a convenient marker to identify and directly sort heterogeneous populations of melanoma cells within the tumor bulk at each stage of melanoma progression.
deletion of Foxc1 and Foxc2 specifically in Pax3-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb
findings suggest a tumor suppressor role for APC/C(Cdh1) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma.
These results demonstrate a requirement for endoglin in descendants of Pax3-expressing vascular cell precursors.
Results suggest that regional Pax3 expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis
we show that the ability of Pax3 to induce the skeletal myogenic cell fate occurs at the expenses of the cardiac lineage.
Pax3 activity is regulated by the Hippo pathway and Pax factors are Hippo effectors.
Loss of Pax3 expression is associated with craniofacial abnormalities.
the PAX3-NCOA2 fusion gene has a dual role in the tumorigenesis of rhabdomyosarcoma
positive input from the neural-specific transcription factor Sox2. Altogether, our data provide important mechanistic insights into the coordinated integration of different signaling pathways on a short Pax3 CRM.
BMP, Wnt and FGF signaling are needed for expression of the neural plate border specifiers pax3a and zic3 in zebrafish
evidence of YAP's role in regulating pax3 neural crest expression
Pax3 in zebrafish is required for specification of two specific lineages of neural crest, xanthophores and enteric neurons.
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2\;13)(q35\;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.
paired box 3
, paired box protein 3
, paired box gene 3 (Waardenburg syndrome 1)
, Paired-domain transcription factor Pax3
, Waardenburg syndrome 1
, paired box protein Pax-3
, paired-box 3
, paired box protein Pax-3-like
, paired box 3 b
, paired box protein Pax-3-B
, paired-domain transcription factor Pax3-B
, paired box gene 3
, paired box homeotic gene 3
, paired domain gene 3
, paired domain gene HuP2
, paired-box 3 protein
, homeodomain protein PAX3