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C-kit-positive hematopoietic stem/progenitor cells expressed significantly higher of Nox1 (show NOX1 Proteins) and catalase (show CAT Proteins), but less of lactoperoxidase (show LPO Proteins) than in matured mononuclear cells.
c-KIT signaling regulates self-renewal capacity and prevents neurodifferentiation in culture.
These findings identify functional redundancy among Kit-dependent hematopoietic lineages and establish an unanticipated capacity of megakaryocytes to mediate IL-1 (show IL1A Proteins)-driven systemic inflammatory disease.
WNT (show WNT2 Proteins) signaling at an early stage (E12 (show ELSPBP1 Proteins)-E15) of submandibular salivary gland (SMG (show SNRPG Proteins)) development inhibits end bud morphogenesis and differentiation into proacini by suppressing Kit expression.
c-kit can reduce inflammation, positively modulate airway remodeling, and improve function in a mouse model of airway hyperresponsiveness
Kit inactivation within oocytes also led to premature ovarian failure, albeit via a contrasting phenotype. Despite normal initial complements of primordial follicles, oocytes remained dormant with arrested oocyte maturation. Foxo3 (show FOXO3 Proteins) protein localization in the nucleus versus cytoplasm explained both mutant phenotypes.
sca-1 antibody reduces both CD34+/c-kit+ progenitor cell surge and vascular restenosis after endoluminal vascular injury in a murine model.
These findings indicate the SCF (show KITLG Proteins)/Kit signaling insufficiency may contribute to the underdevelopment of ICCs and intestinal motility dysfunction upon hypoxia exposure.
we identified important roles for the GATA-2 C-ZnF in bone marrow hematopoiesis via control of c-Kit expression and HSC/HSPC survival.
IMC-G4 cells had an additional novel c-kit gene mutation of KIT-Tyr421Cys which is considered to induce neoplastic transformation of mouse mast cells
Results find that COA6 associates with COX2 and is crucial for its maturation and complex IV biogenesis. Also, COA6 interacts with the copper chaperone SCO1 which indicates that COA6 is intrinsically involved in the copper delivery process for COX2.
Sco1 is a metallochaperone that selectively transfers Cu(I) ions based on loop recognition, whereas Sco2 is a copper-dependent thiol reductase of the cysteine ligands in the oxidase.
COX20 cooperates with SCO1 and SCO2 (show SCO2 Proteins) to mature COX2 and promote the assembly of cytochrome c (show CYCS Proteins) oxidase.
COX19 (show COX19 Proteins) is necessary for the transduction of a SCO1-dependent mitochondrial redox signal that regulates ATP7A (show ATP7A Proteins)-mediated cellular copper efflux.
Results describe the tissue distribution of SCO1 and SCO2 in mouse and human tissues.
SCO1 facilitates the transfer of copper from SCO2 (show SCO2 Proteins) to the CuA site at an early stage of COX (show COX8A Proteins) assembly in mitochondria.
data suggest that both Cu(I) and Cu(II) binding are critical for normal Sco (show SNAI1 Proteins) function.
Cox17-mediated copper metallation of Sco1, as well as the subsequent failure of Cu(A) site maturation, is the basis for the inefficient assembly of the cytochrome c oxidase complex in SCO1 patients
Sco1 has evolved to bind a metal atom via the di-Cys (show DNAJC5 Proteins) motif to act as a copper chaperone, the oxidized form of the nickel-bound protein suggests that it may also maintain the thioredoxin (show TXN Proteins) function.
These results suggest a mitochondrial pathway for the regulation of cellular copper content that involves signaling through SCO1 and SCO2, perhaps by their thiol redox or metal-binding state.
Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene.
Dominant white spotting
, Steel Factor Receptor
, c-kit proto-oncogene protein
, dominant spotting
, mast/stem cell growth factor receptor Kit
, proto-oncogene c-Kit
, proto-oncogene tyrosine-protein kinase Kit
, spotted sterile male
, tyrosine-protein kinase Kit
, protein SCO1 homolog, mitochondrial
, SCO cytochrome oxidase deficient homolog 1