SCO1 Protein (GST tag)

Catalog No. ABIN7318963

Product Details

Target: SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SCO1 protein is labelled with GST tag.

Purpose: Recombinant Human SCO1/SCOD1 Protein (GST Tag)

Sequence: Gly132-Ser300

Characteristics: Recombinant Human Protein SCO1 Homolog Mitochondrial is produced by our E.coli expression system and the target gene encoding Gly132-Ser300 is expressed with a GST tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 50 mM PB, 1 mM DTT, pH 7.2.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))

Alternative Name: SCO1/SCOD1 (SCO1 Products)

Synonyms: SCOD1 Protein, 2610001C07Rik Protein, D11Bwg1310e Protein, SCO1 Protein, RGD1559538 Protein, SCO1, cytochrome c oxidase assembly protein Protein, SCO1 cytochrome c oxidase assembly protein Protein, SCO1 Protein, Sco1 Protein, sco1 Protein

Background:

Background: Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4D). A disorder of the mitochondrial respiratory chain has heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs.

Synonym: Protein SCO1 Homolog Mitochondrial, SCO1, SCOD1

Molecular Weight: 20.1 kDa

UniProt: O75880

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity