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Chicken Polyclonal SOD2 Primary Antibody for ELISA, ICC - ABIN151490
Dumont, Wille, Stack, Calingasan, Beal, Lin: Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
Show all 17 Pubmed References
Rat (Rattus) Polyclonal SOD2 Primary Antibody for WB - ABIN152304
Siu, Alway: Id2 and p53 participate in apoptosis during unloading-induced muscle atrophy. in American journal of physiology. Cell physiology 2005
Show all 6 Pubmed References
Human Polyclonal SOD2 Primary Antibody for IF (p), IHC (p) - ABIN737361
Khan, Chen, Wan, Tania, Xu, Chen, Zhang: Regulatory effects of resveratrol on antioxidant enzymes: a mechanism of growth inhibition and apoptosis induction in cancer cells. in Molecules and cells 2013
Show all 6 Pubmed References
Human Polyclonal SOD2 Primary Antibody for IHC (fro), IHC (p) - ABIN151468
Dumont, Stack, Elipenahli, Jainuddin, Gerges, Starkova, Yang, Starkov, Beal: Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011
Show all 5 Pubmed References
Rat (Rattus) Polyclonal SOD2 Primary Antibody for WB - ABIN152303
Shi, So, Man, Vanhoutte: Oxygen-derived free radicals mediate endothelium-dependent contractions in femoral arteries of rats with streptozotocin-induced diabetes. in British journal of pharmacology 2007
Show all 3 Pubmed References
Chicken Polyclonal SOD2 Primary Antibody for IP, IHC - ABIN361648
Adachi, Ohta, Yamada, Futenma, Kato, Hirano: Quantitative analysis of extracellular-superoxide dismutase in serum and urine by ELISA with monoclonal antibody. in Clinica chimica acta; international journal of clinical chemistry 1993
Show all 10 Pubmed References
Chicken Polyclonal SOD2 Primary Antibody for ICC, IF - ABIN361656
Gao, Flores, Leff, Bose, McCord: Synthesis and anti-inflammatory activity of a chimeric recombinant superoxide dismutase: SOD2/3. in American journal of physiology. Lung cellular and molecular physiology 2003
Show all 10 Pubmed References
Human Polyclonal SOD2 Primary Antibody for IHC, IHC (p) - ABIN4355070
Lindfors, Nilsson, Garcia-Roves, Zuberi, Karimi, Donahue, Roopenian, Mulder, Uhlén, Ekström, Davisson, Hökfelt, Schalling, Johansen: Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse. in Proceedings of the National Academy of Sciences of the United States of America 2011
Show all 3 Pubmed References
Human Polyclonal SOD2 Primary Antibody for ICC, IF - ABIN4355072
Davis, Collier, Leonardo, Seifert, Ajmo, Pennypacker: Leukemia Inhibitory Factor Protects Neurons from Ischemic Damage via Upregulation of Superoxide Dismutase 3. in Molecular neurobiology 2016
Show all 2 Pubmed References
Human Polyclonal SOD2 Primary Antibody for WB - ABIN520368
Rodriguez-Rocha, Garcia-Garcia, Pickett, Li, Jones, Chen, Webb, Choi, Zhou, Zimmerman, Franco: Compartmentalized oxidative stress in dopaminergic cell death induced by pesticides and complex I inhibitors: distinct roles of superoxide anion and superoxide dismutases. in Free radical biology & medicine 2014
Prion (show PRNP Antibodies) propagation exacerbates an apoptotic pathway whereby mitochondrial dysfunction follows mislocalisation of SOD2 to cytosolic caspases permitting its degradation.
Depletion of superoxide dismutases promotes muscular and neuronal ROS (show ROS1 Antibodies) accumulation which may have a significant effect on age-dependent impairment of the Drosophila adults.
Paraquat exposure, but not Sod2 knockdown, resulted in increased carbonylated protein relative abundance.
The functional SOD1 (show SOD1 Antibodies) and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions.
ocytes lacking maternal SOD2 protein develop into adults just like normal SOD2-containing oocytes suggesting that maternal SOD2-mediated protection against mitochondrial ROS (show ROS1 Antibodies) is not essential for oocyte viability
Muscles appear to be more sensitive to superoxide attack relative to the neurons and such overt phenotypes observed in SOD2-deficient animals can be directly attributed to the muscle.
Overexpression of Cu,ZnSOD (show SOD1 Antibodies) and MnSOD in transgenic Drosophila.
Ablation of mitochondrial SOD2 through expression of a GAL4 (show LGALS4 Antibodies)-regulated, inverted-repeat Sod2 RNA-interference causes increased endogenous oxidative stress, loss of respiratory chain & TCA cycle components,& early-onset mortality in young adults.
Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity.
The chromosomal deficiency Df(2R)017 significantly up-regulated MnSOD mRNA by 1.7-fold. Deficiency in four other genomic intervals, Df(1)ct-J4, Df(2L)BSC4, Df(3L)66C-G28 and Df(3R)Scr (show SCRIB Antibodies), down-regulated MnSOD expression.
SOD1 (show SOD1 Antibodies) and SOD2 provide independent protection to compartment-specific protein iron-sulfur clusters against attack by superoxide generated under oxidative stress
SOD2 gene polymorphism may modulate biochemical responses to a 12-week swimming training.
Study shows an association of the polymorphism of MnSOD 47C/T in the Algerian population with type 1 diabetes without complications.
MnSOD is the major superoxide scavenger in mitochondria, whose activity is regulated by SIRT3 (show SIRT3 Antibodies)-mediated deacetylation, particularly at the Lys68 site, and can be enhanced by a SIRT3 (show SIRT3 Antibodies) coumarin derivative.
Heavy alcohol drinking down-regulates ALDH2 (show ALDH2 Antibodies) gene expression level. Heavy smoking up-regulates SOD2 gene expression level in patients with head and neck squamous cell carcinoma.
This is the first report evaluating the role of SOD2 in native and T351-mutated BCR-ABL (show ABL1 Antibodies)-expressing cells and in a large cohort of chronic myeloid leukemia (show BCL11A Antibodies) patients. In leukemic cells silenced for SOD2 expression a specific down-regulation of the expression of PRDX2 (show PRDX2 Antibodies) gene was found.
The investigated MnSOD and Catalase (show CAT Antibodies) polymorphisms do not predispose to the development of alcoholic Chronic Pancreatitis.
Allele-specific interaction between GPX1 (show GPX1 Antibodies) and MnSOD affects the levels of Bcl2 (show BCL2 Antibodies), Sirt3 (show SIRT3 Antibodies) and E-cadherin (show CDH1 Antibodies).
Studies suggest that both SOD3 (show SOD3 Antibodies) and SOD2 superoxide dismutases are regulated by oxidative stress and redox-dependent signaling mechanisms.
Data confirmed that SOD2 is important in the development and prognosis of salivary adenoid cystic carcinoma (SACC); that SOD2 deregulation is related to migration and invasion in SACC; and that the SOD2-dependent production of intracellular H2O2 promotes the migration and invasion of SACC, which involves the ERK-Slug signaling pathway.
This study builds upon in vivo investigation examined the heroin dependency risk associated with the rs2758339 and rs5746136 polymorphisms, as well as their relationship with the SOD2 mRNA levels in normal peripheral blood cells. The findings of the present study indicated that the study polymorphisms are significantly associated with the risk of dependency to heroin but are not associated with the SOD2 expression level.
The results showed that 60-min ischemia of the porcine uterus conducted at the mid-secretory estrous phase caused decreased HIF-1alpha (show HIF1A Antibodies) and increased SOD-2 gene expression.
show that ischemia markedly potentiated the expression of arginase-1 (show ARG1 Antibodies), and also induced the SOD2 in the wound tissue.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2, GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1 (show NR3C1 Antibodies). TNF (show TNF Antibodies) and IL6 (show IL6 Antibodies) levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
Data suggest that during ectogenesis of blastocysts infected with bovine Herpesvirus type 5, expression of SOD2 (Mn) remains high indicating intense mitochondrial activity; this effect may be involved in inhibition of apoptosis in infected embryos.
expression profile of SOD2 in follicles: oocytes (SOD2 restricted to ooplasm (show NLRP5 Antibodies)); cumulus cells (expressed some SOD2); follicular fluid (small follicles show increased amounts of SOD2 in comparison with large follicles)
Shear stress influences spatial variations in vascular Mn-SOD expression with implications for LDL nitration.
The expression of SOD1 (show SOD1 Antibodies) and SOD2 through the course of the estrous cycle is reported.
Heart mitochondrial nucleoids contained SOD2, aortic endothelial cell mitochondrial nucleoids did not
Enhanced mitochondrial oxidative stress under hyperlipidemic conditions in aging induces plaque instability, in part by increasing smooth muscle cell apoptosis, necrotic core expansion, and matrix degradation in Sod2/ApoE (show APOE Antibodies) knockout mice.
Deletion of SOD2 increases mitochondrial reactive oxygen species but does not influence platelet function.
This study reveals a novel model regulating cardiomyocyte apoptosis which is composed of miR (show MLXIP Antibodies)-23a and MnSOD.
data showed that Klotho (show KL Antibodies) protects Tac (show IL2RA Antibodies)-induced oxidative stress by negatively regulating the PI3K/AKT (show AKT1 Antibodies) pathway and subsequently enhancing FoxO3a (show FOXO3 Antibodies)-mediated MnSOD expression.
Moderate MnSOD and/or catalase (show CAT Antibodies) overexpression in desmin (show DES Antibodies)-null hearts leads to a marked decrease in intracellular reactive oxygen species, ameliorates mitochondrial and other ultrastructural defects, minimizes myocardial degeneration and leads to a significant improvement of cardiac function.
this study shows that differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine SOD2-tg heart
SOD2 overexpression blocks maternal diabetes-induced oxidative stress and ER stress, and reduces the incidence of NTDs in embryos exposed to maternal diabetes
the regulation of mitochondrial ROS (show ROS1 Antibodies) by SOD2 and Sirt3 (show SIRT3 Antibodies) plays an important role in fine-tuning the Osteoclast differentiation program.
treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 (show IDH2 Antibodies) knockdown-induced decrease in MnSOD expression, eNOS (show NOS3 Antibodies) phosphorylation and NO production in endothelial cells
On normal salt diet, renal CuZnSOD (show SOD1 Antibodies) and ECSOD (show SOD3 Antibodies) proteins were similar but renal MnSOD was lower in hGRK4g486V than Non-T mice and remained low on high salt diet. hGRK4gammawild-type mice were normotensive and hGRK4g142V mice were hypertensive but both were salt-resistant and in normal redox balance. Chronic tempol treatment partially prevented the salt-sensitivity of hGRK4g486V mice.
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, manganese superoxide dismutase
, Mn Sod
, Mn superoxide dismutase
, superoxide dismutase 2, mitochondrial
, superoxide dismutase [Mn], mitochondrial
, Mn-superoxide dismutase
, mitochodnrial SOD
, mitochondrial Mn-superoxide dismutase 2
, mitochondrial MnSOD
, mitochondrial superoxide dismutase 2
, superoxide dismutase
, superoxide dismutase 2
, superoxide dismutase 2 (Mn)
, superoxide dismutase-2
, indophenoloxidase B
, manganese-containing superoxide dismutase
, mangano-superoxide dismutase
, superoxide dismutase (Mn type)
, manganous superoxide dismutase
, manganese SOD
, Superoxide dimutase 2, mitochondrial