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Human Polyclonal Tricellulin Primary Antibody for ICC, IHC (fro) - ABIN261710
Nguyen, Suzuki, Wakasugi, Hohchi, Hashida, Ohbuchi: Different expressions of erbB1/2 and tight junction proteins in hypertrophic inferior turbinates and nasal polyps. in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2013
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Findings suggest that both tricellular tight junctions proteins TRIC and LSR (show LSR Antibodies) have crucial roles for the differentiated cochlear cell survival.
Tricellulin is a specific redox sensor and sealing element at 3-cell contacts and may compensate as a redox mediator for occludin (show OCLN Antibodies) loss at 2-cell contacts in vivo and in vitro.
GFP-tagged angulin-1/LSR (show LSR Antibodies), in which serine 288 was substituted by alanine, was observed to be dispersed to bicellular junctions, indicating that phosphorylation of Ser288 is crucial for the exclusive localization of angulin-1/LSR (show LSR Antibodies) and tricellulin at tTJs.
localization of angulin-1/LSR (show LSR Antibodies) and tricellulin at tricellular contacts of brain and retinal endothelial cells in vivo
Loss of tricellulin prevented the coalition of the strands of the bicellular junction with the central element of the tricellular junction in the inner ear epithelia.
The findings show the heterogeneity of the molecular organization of tTJs in terms of the content of LSR (show LSR Antibodies), ILDR1 (show ILDR1 Antibodies) or ILDR2, and suggest that ILDR1 (show ILDR1 Antibodies)-mediated recruitment of tricellulin to TCs is required for hearing.
The tricellulin may be a component to maintain the integrity for PNS myelin function and morphology.
marvelD3 (show MARVELD3 Antibodies), occludin (show OCLN Antibodies), and tricellulin define the tight junction-associated MARVEL protein family
In this study, we identify tricellulin, the first integral membrane protein that is concentrated at the vertically oriented TJ strands of tricellular contacts.
In the inner ear, tricellulin is concentrated at the tricellular tight-junctions in cochlear and vestibular epithelia, including the structurally complex and extensive junctions between supporting and hair cells.
Our results provide new insights into the function of tricellulin, and its nuclear localization may become a new prognostic factor for pancreatic cancers.
GSK3beta may inhibit VRK2 (show VRK2 Antibodies) catalytic activity by disrupting its flexibility. The inhibition of VRK2 (show VRK2 Antibodies) catalytic activity by GSK3beta may also inhibit VRK2 (show VRK2 Antibodies)-induced degradation of TRiC, which could suppress polyQ-expanded Htt (show HTT Antibodies) aggregation.
Tricellulin-dependent macromolecule passage was comparably regulated in leaky and tight epithelia, but relative and absolute ion permeabilities of the tricellular tight junction (tTJ) were different.
Data show that the E3 ubiquitin ligase (show MUL1 Antibodies) Itch forms a complex with tricellulin and thereby enhances its ubiquitination.
we demonstrated that PLG (show PLG Antibodies) functions as a molecular bridge between tricellulin and streptococcal surface enolase (SEN (show MORF4 Antibodies)). The wild type strain efficiently translocated across the epithelial monolayer, accompanied by cleavage of transmembrane junctional proteins.
The expressions of MARVELD2, CLDN1 (show CLDN1 Antibodies) and CLDN3 (show CLDN3 Antibodies) mRNA were significantly lower in cholesteatoma tissue and may be involved in epithelium permeability.
High tricellulin expression is associated with hepatocellular carcinoma.
MARVELD2 variants are responsible for about 1.5 % (95 % CI 0.8-2.6) of non-syndromic hearing loss in our cohort of 800 Pakistani families. The c.1331+2T>C allele is recurrent.
This study reveals the presence and subcellular distribution of tricellulin in brain endothelial cells.
The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene.
MARVEL (membrane-associating) domain containing 2
, MARVEL domain-containing protein 2