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Human Polyclonal DOCK1 Primary Antibody for WB - ABIN257645
Hasegawa, Kiyokawa, Tanaka, Nagashima, Gotoh, Shibuya, Kurata, Matsuda: DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. in Molecular and cellular biology 1996
Dock1 modulation by miR (show MLXIP Antibodies)-31 plays an important function in glioma invasion
In summary, this investigation identifies an EGFR (show EGFR Antibodies)-DOCK180-RAC1-MLK3 (show MAP3K11 Antibodies)-JNK (show MAPK8 Antibodies) signaling axis that drives glioblastoma cell migration and dissemination.IMPLICATIONS: On the basis of these findings, MLK3 (show MAP3K11 Antibodies) emerges as a potential therapeutic target for the treatment of glioblastoma
one statistically significant common variant in the DOCK1 gene was associated with DeltaBMI in GI cancer and COPD (show ARCN1 Antibodies) cases providing support for at least partially shared aetiology of DeltaBMI in complex diseases.
Taken together, these results indicate that DOCK1 is a critical regulator of the malignant phenotypes induced by Rac1(P29S), and suggest that targeting DOCK1 might be an effective approach to treat cancers associated with Rac1(P29S) mutation.
Data suggest that GPR124 (show GPR124 Antibodies) promotes cell adhesion via interaction with Elmo1 (show ELMO1 Antibodies)-Dock180 and intersectin 1 (show ITSN1 Antibodies)/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124 (show GPR124 Antibodies)-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 (show GPR124 Antibodies) = G-protein coupled receptor 124 (show GPR124 Antibodies); Elmo1 (show ELMO1 Antibodies) = ELMO domain-containing protein 1 (show ELMOD1 Antibodies); Dock180 = dedicator of cytokinesis protein 1 180 kDa)
stimulation of the DOCK180 pathway represents an alternative mechanism of PTP1B (show PTPN1 Antibodies) inhibitor-stimulated endothelial cell motility, which does not require concomitant VEGFR2 (show KDR Antibodies) activation as a prerequisite.
Thus, Elmo1 (show ELMO1 Antibodies) and Dock180 facilitate blood vessel formation by stabilization of the endothelium during angiogenesis.
High DOCK180 expression is associated with serous ovarian cancer.
our findings describe a novel mechanism by which EGFRvIII drives glioma tumorigenesis and invasion through protein kinase A-dependent phosphorylation of Dock180
findings indicate that a chemokine-controlled pathway, consisting of Galphai2, ELMO1/Dock180, Rac1 and Rac2, regulates the actin cytoskeleton during breast cancer metastasis
Inactivation of Dock1 in mammary gland epithelial cells and activation of Stat3 (show STAT3 Antibodies) coincide with a delay in the initiation of mammary gland involution.
Dock1 and Dock5 (show Dock5 Antibodies) are not the important exchange factors regulating Rac (show AKT1 Antibodies) activity during the establishment and maintenance of the glomerular barrier
DOCK1-Rac (show AKT1 Antibodies) signaling as an HER2 (show ERBB2 Antibodies) effector pathway essential for HER2 (show ERBB2 Antibodies)-mediated breast cancer progression to metastasis.
The phospholipase D (show PLD Antibodies)-PA axis selectively controls dorsal ruffle formation by regulating DOCK1 localization.
The data demonstrate the ability of the SH3 domain (show ITSN1 Antibodies) of DOCK180 to interact with ELMO1 (show ELMO1 Antibodies), regardless of the presence of the polyproline-containing C-terminal end.
Dock1 has an essential role in embryonic development.
Results indicate that the combination of DOCK2 (show DOCK2 Antibodies) and DOCK180 plays a significant but not essential role in prevascular fetal thymus colonization.
A novel signaling cascade is identified in which ELMO1 (show ELMO1 Antibodies)/DOCK180 regulates vasculature formation in zebrafish.
The fusion of embryonic fast-twitch myoblasts requires the activities of Dock1 and the closely related Dock5 (show Dock5 Antibodies) protein.
This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis.
180 kDa protein downstream of CRK
, DOwnstream of CrK
, dedicator of cyto-kinesis 1
, dedicator of cytokinesis protein 1
, dedicator of cytokinesis 1
, dedicator of cytokinesis protein 1-like