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the shiomaneki (sio) gene locus encodes Col4a6 (show COL4a6 Proteins), a subunit of type IV collagen (show COL4 Proteins), which, in a complex with Col4a5, is a basement membrane (BM) component. Both col4a5 and col4a6 (show COL4a6 Proteins) mutants displayed similar abnormalities in the axogenesis
During motor axon regeneration, col4a5 destabilizes axons probing inappropriate trajectories to ensure target-selective regeneration, possible through slit1a.
Genetic and biochemical studies indicate that Slit binds to Dragnet (Col4a5) which forms the basement membrane on the surface of the tectum.
Our study showed that the rs544012 AC and rs679505 AA genotypes were independently associated with the risk of ICH in the Chinese Han population and that the AA haplotype (rs3742207-rs11069830) in the COL4A1 gene may be related to the risk of ICH in the Chinese Han population
The rs532625 AA genotype in the COL4A1 gene was independently associated with the risk of disability and death in a Chinese Han population following intracerebral hemorrhage.
this study shows that COL4A1 production by urothelial carcinoma of the bladder plays a pivotal role in tumor invasion through the induction of tumor budding
Strong correlations between the expression of type I, II, IV collagen and osteopontin (show SPP1 Proteins) and the clinical stage of tympanosclerosis indicate the involvement of these proteins in excessive fibrosis and pathological remodeling of the tympanic membrane.
Genotype-phenotype correlations in pathology caused by COL4A1 and COL4A2 (show COL4a2 Proteins) mutations have been summarized. (Review)
Urine levels of COL4A1, COL13A1 (show COL13A1 Proteins), the combined values of COL4A1 and COL13A1 (show COL13A1 Proteins) (COL4A1 + COL13A1 (show COL13A1 Proteins)), and CYFRA21-1 were significantly elevated in urine from patients with BCa (show BLNK Proteins) compared to the controls. A high urinary COL4A1 + COL13A1 (show COL13A1 Proteins) was found to be an independent risk factor for intravesical recurrence.
Building collagen IV (show COL4 Proteins) smart scaffolds on the outside of cells has been summarized. (Review)
Our findings extend the spectrum of COL4A1 mutations linked with renal disease and demonstrate that the highly conserved C-terminal part of the NC1 domain of the alpha1 chain of type IV collagen (show COL4 Proteins) is important in the integrity of glomerular basement membrane in humans.
Twist1 (show TWIST1 Proteins) appears to require both palladin (show PALLD Proteins) and collagen alpha1(VI) as downstream effectors for its prometastatic effects, which could be future therapeutic targets in cancer metastasis.
only collagen-IV (show COL4 Proteins) elicits the formation of proteolytically active podosomes through a mechanism involving increased Src (show SRC Proteins) phosphorylation, p190RhoGAP (show GRLF1 Proteins)-B (also known as ARHGAP5) relocalisation and MT1-MMP (show MMP14 Proteins) (also known as MMP14 (show MMP14 Proteins)) cell surface exposure at podosome sites.
Col4a1 mutation generates vascular abnormalities correlated with neuronal damage in a mouse model of HANAC syndrome
Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit (Col4a1, GPBP (show COL4A3BP Proteins), Lamc1 (show LAMC1 Proteins), peroxidasin) during uterine reprogramming.
DDR1 (show DDR1 Proteins) kinase activity is required for regulating collagen IV (show COL4 Proteins) synthesis.
the lens and possibly vasculature play important roles in Col4a1-related anterior segment dysgenesis.
Mutations in murine Col4a1 and Col4a2 (show COL4a2 Proteins) genes affected the balance between lung epithelial progenitors and differentiated cells. Mutations in Col4a1 derived from the vascular component were sufficient to cause defects in vascular development and the blood-gas barrier. Col4a1 and Col4a2 (show COL4a2 Proteins) mutants displayed disrupted myofibroblast proliferation, differentiation and migration.
This extensive description of the muscular phenotype of the Col4a1 HANAC murine model suggests a potential contribution of primary endothelial cell defects, together with muscle BM alterations, to the development of COL4A1-related myopathy.
The findings indicate the critical role of CatB in regulating the expression of collagens III and IV by fibroblasts via prolonging TLR2/NF-kappaB (show NFKB1 Proteins) activation and oxidative stress.
data show that both basement membrane defects and ER stress contribute to Col4a1 renal disease, which has important implications for the development of treatment strategies for collagenopathies
Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A (show PDGFA Proteins)), a potent chemotactic factor for fibroblasts.
Col4a1 mutations cause abnormal vascular development, which triggers small-vessel disease, recurrent hemorrhagic strokes, and age-related macroangiopathy.
High shear stress up-regulates type IV collagen (show COL4 Proteins) synthesis and down-regulates MMP-2 (show MMP2 Proteins) secretion in endothelial cells.
alpha1.alpha2 stabilize the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys (show LYZ Proteins) cross-links
This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
collagen alpha-5(IV) chain
, type IV collagen alpha 1
, collagen, type IV, alpha 1
, collagen type IV alpha 1 chain
, collagen alpha-1(IV) chain-like
, COL4A1 NC1 domain
, collagen IV, alpha-1 polypeptide
, collagen alpha-1(IV) chain
, collagen of basement membrane, alpha-1 chain
, alpha1(IV) collagen
, procollagen, type IV, alpha 1
, retinal anterior wiring
, alpha 1 type IV collagen
, collagen IV a1 chain