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anti-Human AIF1 Antibodies:
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Human Polyclonal AIF1 Primary Antibody for ELISA, ICC - ABIN249515
Del Galdo, Maul, Jiménez, Artlett: Expression of allograft inflammatory factor 1 in tissues from patients with systemic sclerosis and in vitro differential expression of its isoforms in response to transforming growth factor beta. in Arthritis and rheumatism 2006
Show all 61 Pubmed References
Human Polyclonal AIF1 Primary Antibody for IF (p), IHC (fro) - ABIN685477
Ogawa, Onozato, Okuhara, Nagasawa, Tamura, Hayashi: Spontaneous cutaneous soft tissue sarcoma with differentiation into fibroblasts in a Sprague-Dawley rat. in Journal of toxicologic pathology 2016
Show all 5 Pubmed References
Human Polyclonal AIF1 Primary Antibody for IP, IHC - ABIN1742480
Smith, Schmeltzer, Packard, Sah, Herman: Divergent effects of repeated restraint versus chronic variable stress on prefrontal cortical immune status after LPS injection. in Brain, behavior, and immunity 2016
Show all 2 Pubmed References
Human Monoclonal AIF1 Primary Antibody for IA, IHC (p) - ABIN2192043
Schluesener, Seid, Kretzschmar, Meyermann: Allograft-inflammatory factor-1 in rat experimental autoimmune encephalomyelitis, neuritis, and uveitis: expression by activated macrophages and microglial cells. in Glia 1998
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Human Polyclonal AIF1 Primary Antibody for IHC (p), WB - ABIN654407
Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: New genetic associations detected in a host response study to hepatitis B vaccine. in Genes and immunity 2010
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Human Polyclonal AIF1 Primary Antibody for ELISA, IHC - ABIN4278828
Arsenault, Coulombe, Zhu, Gong, Kil, Choi, Poutiainen, Brownell: Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS. in PLoS ONE 2015
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Human Polyclonal AIF1 Primary Antibody for IHC (p), WB - ABIN5518728
Xiao, Zhang, Zhang, Wang, Chen, Chen, Lv, Shi, Dong: Re-infection of the prion from the scrapie‑infected cell line SMB-S15 in three strains of mice, CD1, C57BL/6 and Balb/c. in International journal of molecular medicine 2016
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Human Polyclonal AIF1 Primary Antibody for IF (p) - ABIN685481
Song, Gaudin, King, Seo, Suh, Deng, Cui, Tietjen, Huttner, Saltzman: Surface chemistry governs cellular tropism of nanoparticles in the brain. in Nature communications 2017
Human Polyclonal AIF1 Primary Antibody for IHC (p), ELISA - ABIN2477309
Wang, Wang, Wang, Zhao, Zhang, Wang, Zhang, Wu, Yang: Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-?B, MAPKs and Akt signaling pathways. in Neuropharmacology 2014
Human Monoclonal AIF1 Primary Antibody for ELISA, WB - ABIN559819
Köhler: Allograft inflammatory factor-1/Ionized calcium-binding adapter molecule 1 is specifically expressed by most subpopulations of macrophages and spermatids in testis. in Cell and tissue research 2007
Small interfering RNA (siRNA)-mediated silencing of AIF-1 expression resulted in a reduction in cell proliferation and migration in human HCC cells.
It may be speculated that Iba-1 protein besides its major function (involvement in phagocytosis) can perform the role of a transcriptional factor.
This study shown the AIF1 expression in Microglia and Astrocytes in stroke, Alzheimer's disease, and Lewy body dementia.
involved in the immunological process underlying rheumatoid arthritis
Using double labeling with Iba-1 and cd68 could determine the physiological state of microglia in brain contusion based on their morphology and immunoreactivity.
The results of our study suggest that the AIF1 gene polymorphisms have no influence on long-term kidney allograft function.
Data showed that AIF-1 promoted the proliferation of HepG2 cells by accelerating the activation of IGF-1R and its downstream signaling pathway, which confirms that AIF-1 plays a crucial role in the development of hepatocellular carcinoma cells.
AIF-1 functions as a tumor suppressor possibly by regulating beta-catenin in gastric cancer. the level of AIF-1 expression may serve as a protective prognostic indicator for gastric cancer.
AIF-1, which induced chemokines and enhanced chemotaxis of monocytes, may represent a molecular target for the therapy of immune-inflammatory disorders
The results of this study suggest a lack of association between AIF-1 gene polymorphisms and response to sulphasalazine treatment in rheumatoid arthritis.
The results of this study suggest that the patients with the rs2259571 CC AIF1 genotype have a poorer response to therapy with Methotrexate.
We are unable to find statistically significant association between COX-2 and AIF-1 gene polymorphisms and allograft survival.
The overexpressed AIF-1, the novel inflammatory polypeptide derived from macrophage lineages, is closely associated with atherogenesis via affecting the blood composition and promoting macrophage uptake and foam cell formation.
AIF-1 can protect rheumatoid arthritis fibroblast-like synoviocytes from apoptosis induced by NO by upregulating the expression of p-Akt and p-BAD.
daintain/AIF-1 reinforced the resistance of breast cancer cells to cisplatin by inhibition of cell apoptosis and reduction of intracellular cisplatin accumulation
Serum AIF-1 concentration correlated with albuminuria and eGFR in patients with type 2 diabetes and it could be a marker of diabetic nephropathy as well as activated macrophages.
Our results suggest that the AIF1 rs2259571 CC genotype is associated with the active form of RA.
The serum AIF-1 concentrations were positively correlated with levels of fasting plasma glucose, hemoglobin A1c, triglycerides, and uric acid, and with waist circumference and BMI, and were inversely correlated with HDL cholesterol levels.
Overexpression of AIF-1 stimulates migration and proliferation of human vascular smooth muscle cells, whereas IRT-1 exerts opposite effects.
Our data suggest that SNPs in or near the AIF1 locus contribute to obesity risk in the Greek population.
Aif1 is important for bacterial and particle transcytosis in M cells.
These findings indicate that the expression of AIF-1 in macrophages is critical for the activation of renal fibroblasts to a profibrotic phenotype.
Macrophage-derived AIF-1 up-regulated reactive oxygen species production, adipokine TNFalpha, IL6, resistin release, and inhibited adiponectin secretion.
A new subset of resident macrophages in the intestinal muscularis externa was discovered, identified as iba1(pos) CD169(neg).
These results suggest that AIF-1 plays an important role in the mechanism underlying lung fibrosis, and may provide an attractive new therapeutic target.
AIF-1 plays an important role in the mechanism underlying acute lung injury.
These results imply daintain/AIF-1 triggers type 1 diabetes probably via arousing immune cells activation and induction of NO production in pancreas of NOD mice.
AIF-1 was overexpressed in the liver of BALB/c mice infected with S. japonicum, and the interaction between AIF-1 and TNF-alpha or other cytokines played an important role in the pathogenesis and progression of hepatic schistosomiasis.
Data suggest a strong association between AIF-1 expression, NF-kappaB activation, and development of experimental atherosclerosis.
AIF-1 can induce IL-6 secretion on mononuclear cells and fibroblast chemotaxis. AIF-1 may accordingly provide an attractive new target for antifibrotic therapy in SSc as well as Scl GVHD.
interferon gamma inducable and macrophage restricted expression requires Pu.1
This study demonstrated for the first time that allograft inflammatory factor-1(AIF-1) was expressed in uterus, and a correlation between AIF-1 production and fetal resorption in mice.
These data indicate that AIF-1 mediates atherogenesis-initiated signaling and activation of macrophages.
The molecular conformational change induced by Ca(2+)-binding of Iba1 is different from that found in the classical EF-hand proteins, which demonstrates that Iba1 has an unique molecular switching mechanism dependent on Ca(2+)-binding.
AIF-1/Iba1 can be regarded a "pan-macrophage marker" because, except for alveolar macrophages, all subpopulations of macrophages examined express AIF-1/Iba1.
allograft inflammatory factor 1 (AIF-1) expression results in increased signal transduction, neointimal formation, and vascular smooth muscle cell proliferation in injured mouse carotid arteries.
These results suggest that enhanced AIF-1 expression leads to augmented incorporation of degenerated LDL by macrophages and promotes development of atherosclerotic vasculopathy.
Iba1 was heavily expressed in the VM-M2, VM-M3 and RAW cells, but was mostly undetectable in the VM-NM1 cells and the AC cells. These findings support the microglial/macrophage origin of the metastatic VM-M2, VM-M3 tumor cells.
AIF-1 is expressed in endothelial cells, macrophages and T cells in systemic sclerosis (SSc).
apoptosis-inducing factor(AIF) was expressed in luminal alveolar cells and in concert with a change in bax protein to bcl-2 protein ratio might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses(AIF)
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene.
allograft inflammatory factor-1 splice variant Hara-1
, interferon gamma responsive transcript
, ionized calcium-binding adapter molecule 1
, protein G1
, ionized calcium binding adapter molecule 1
, testis specific
, balloon angioplasty responsive transcript
, balloon angioplasty-responsive transcript 1
, microglia response factor
, protein BART-1
, allograft inflammatory factor 1
, anti-inflammatory factor 1
, Allograft inflammatory factor 1