Browse our anti-GATA2 (GATA2) Antibodies

Human GATA Binding Protein 2 (GATA2) interaction partners

1. Gata2 and miR (show MLXIP Antibodies)-124-3p are potential novel reporter biomolecules for ovarian cancer.

2. although relatively infrequent in patients with hypertrophic cardiomyopathy, GATA2, 4 and 6 transcription factors may represent a novel insight into the molecular mechanisms related to the pathogenesis of hypertrophic cardiomyopathy

3. in our study on a large cohort of CEBPAmut AML (show RUNX1 Antibodies) patients, we found a high coincidence of GATA2mut, in particular within the subgroup of patients with CEBPAbi mutations

4. Androgen receptor (show AR Antibodies) transcriptionally regulates semaphorin 3C (show SEMA3C Antibodies) in a GATA2-dependent manner in prostate tumor cells.

5. Study identified the novel role of transcription factors GATA-2 and GATA-3 (show GATA3 Antibodies) in suppressing MICA (show MICA Antibodies)/B expression in HBV-infected human hepatoma cells.

6. GATA2 mutation-related immunodeficiency may predispose to Epstein-Barr virus-associated subacute demyelinating polyradiculoneuropathy by both viral susceptibility and immune dysregulation

7. The absence of deleterious mutations in this large cohort of familial aggregations of hematological malignancies may strengthen the hypothesis that GATA2 mutations are an important predisposing factor, although as a secondary genetic event, required for the development of overt malignant disease

8. Gata2 regulates a key regulatory network of gene expression for progesterone signaling at the early pregnancy stage.

9. p38 (show CRK Antibodies)-dependent mechanism that phosphorylates GATA-2 and increases GATA-2 target gene activation has been demonstrated. This mechanism establishes a growth-promoting chemokine (show CCL1 Antibodies)/cytokine circuit in acute myeloid leukemia (show BCL11A Antibodies) cells.

10. we report a family with a null mutation in GATA2 and Emberger syndrome with variable expressivity and incomplete penetrance. This case emphasizes the need of genetic interactions to produce specific phenotypes in the clinical spectrum of GATA2 deficiency, where no precise genotype-phenotype correlation has been found.

Xenopus laevis GATA Binding Protein 2 (GATA2) interaction partners

1. bcar3 gene is expressed downstream of Gata2 during gastrulation, and is co-expressed with gata2 but is more broadly expressed during later development; its binding partner, bcar1 (show BCAR1 Antibodies) shows overlapping expression patterns

2. results are consistent with a model in which GATA2 contributes to inhibition of canonical Wnt (show WNT2 Antibodies) signaling

3. these findings, strongly implicate Dlx3 in the regulation of non-neural competence, and show that GATA2 contributes to non-neural competence but is not sufficient to promote it ectopically.

4. Studies suggest a two-component model for the binding of CBTF with gata2 promoter, requiring both a CCAAT and A-form DNA, and the double stranded RNA binding domains (dsRBDs) of CBTF component Xilf3 must be active for both binding to the promoter.

5. Gata-2 is a transcriptional target downstream of BMPs within ectodermal cells, while activation of the CaM KIV signaling pathway alters GATA-2 function posttranslationally, by inhibiting its acetylation.

Cow (Bovine) GATA Binding Protein 2 (GATA2) interaction partners

1. GATA2 and/or GATA3 (show GATA3 Antibodies) are involved in the regulation of trophoblast-specific gene transcription in bovine trophoblast CT-1 (show SLC6A8 Antibodies) cells

Mouse (Murine) GATA Binding Protein 2 (GATA2) interaction partners

1. We demonstrate that overexpression of Gfi1b (show GFI1B Antibodies), c-Fos, and Gata2, previously reported to transdifferentiate fibroblasts into hematopoietic progenitors in vitro, can induce long-term HSC (show FUT1 Antibodies) formation in vivo.

2. GATA2 could affect the function of BM-MSCs in vivo, presumably by regulating the expression of extracellular signals.

3. Gata2 regulates a key regulatory network of gene expression for progesterone signaling at the early pregnancy stage.

4. Results show that GATA2 exerts a pro-inflammatory function in injured kidney collecting duct cells, by upregulating inflammatory cytokine gene expression thereby contributes to disease progression.

5. Gata2 mRNA levels were almost completely rescued by expression of an erythroid lineage restricted ROSA26-promotor based GATA2 transgene

6. Gata2 heterozygous deletion confers selective advantage to EVI1 (show MECOM Antibodies)-expressing leukemia cell expansion in recipient mice

7. impairment of trophoblast-specific GATA2/GATA3 (show GATA3 Antibodies) function could lead to early pregnancy failure

8. both Gata2 and Gata3 (show GATA3 Antibodies) are redundantly required for differentiation of the serotonergic and glutamatergic neurons of the dorsal raphe

9. Dynamically and epigenetically coordinated GATA2/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation.

10. High GATA2 expression is associated with leukemia.