-
These findings suggest that GATA2 deficient patients may have an increased risk of melanoma and should be observed closely for new or changing skin lesions.
-
Our novel finding of dynamic pulsatile expression of Gata2 suggests a highly unstable genetic state in single cells concomitant with their transition to hematopoietic fate. This reinforces the notion that threshold levels of Gata2 influence fate establishment and has implications for transcription factor-related hematologic dysfunctions.
-
Two GATA2 mutants (gT354M and gC373R) bound the key hematopoietic differentiation factor PU.1.
-
Study identifies the GATA2 transcription factor as a critical regulator of matrix stiffness induced transcriptional program in the in lymphatic endothelial cells (LECs). As opposed to the previously reported activation of GATA2 by increased mechanical stimulus upon exposure of LECs to stiff matrix or oscillatory flow, study found that GATA2 expression is increased in LECs grown on a soft matrix.
-
endothelial SENP1-mediated SUMOylation drives graft arteriosclerosis by regulating the synergistic effect of GATA2 and NF-kappaB and consequent endothelial dysfunction.
-
To analyze the outcomes of COS in women with GATA2 deficiency.
-
Data suggest that the stress of intermittent hypoxia up-regulates expression of mRNA and protein for POMC and CART in neuronal cell lines; GATA2 and GATA3 appear to be involved in these stress mechanisms. (POMC = proopiomelanocortin; CART = cocaine- and amphetamine-regulated transcript protein; GATA2 = endothelial transcription factor GATA-2; GATA3 = T-cell-specific transcription factor GATA-3)
-
In the Title.
-
Gata2 and miR-124-3p are potential novel reporter biomolecules for ovarian cancer.
-
although relatively infrequent in patients with hypertrophic cardiomyopathy, GATA2, 4 and 6 transcription factors may represent a novel insight into the molecular mechanisms related to the pathogenesis of hypertrophic cardiomyopathy
-
in our study on a large cohort of CEBPAmut AML patients, we found a high coincidence of GATA2mut, in particular within the subgroup of patients with CEBPAbi mutations
-
Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner in prostate tumor cells.
-
Study identified the novel role of transcription factors GATA-2 and GATA-3 in suppressing MICA/B expression in HBV-infected human hepatoma cells.
-
GATA2 mutation-related immunodeficiency may predispose to Epstein-Barr virus-associated subacute demyelinating polyradiculoneuropathy by both viral susceptibility and immune dysregulation
-
The absence of deleterious mutations in this large cohort of familial aggregations of hematological malignancies may strengthen the hypothesis that GATA2 mutations are an important predisposing factor, although as a secondary genetic event, required for the development of overt malignant disease
-
Gata2 regulates a key regulatory network of gene expression for progesterone signaling at the early pregnancy stage.
-
p38-dependent mechanism that phosphorylates GATA-2 and increases GATA-2 target gene activation has been demonstrated. This mechanism establishes a growth-promoting chemokine/cytokine circuit in acute myeloid leukemia cells.
-
we report a family with a null mutation in GATA2 and Emberger syndrome with variable expressivity and incomplete penetrance. This case emphasizes the need of genetic interactions to produce specific phenotypes in the clinical spectrum of GATA2 deficiency, where no precise genotype-phenotype correlation has been found.
-
Studied GATA2 Deficiency With Severe Primary Epstein-Barr Virus (EBV) Infection and EBV-associated Cancers. Seven patients with GATA2 deficiency developed severe EBV disease. Also found GATA2 to be the first gene associated with EBV hydroa vacciniforme-like lymphoma.
-
GATA2 deficiency is associated with impaired membrane expression and chemotactic dysfunctions of CXCR4.
