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Human Polyclonal LIN28A Primary Antibody for ICC, IF - ABIN4331040
Boj, Hwang, Baker, Chio, Engle, Corbo, Jager, Ponz-Sarvise, Tiriac, Spector, Gracanin, Oni, Yu, van Boxtel, Huch, Rivera, Wilson, Feigin, Öhlund, Handly-Santana, Ardito-Abraham, Ludwig, Elyada et al.: Organoid models of human and mouse ductal pancreatic cancer. ... in Cell 2015
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Human Monoclonal LIN28A Primary Antibody for ICC, ELISA - ABIN968936
Gerecht-Nir, Dazard, Golan-Mashiach, Osenberg, Botvinnik, Amariglio, Domany, Rechavi, Givol, Itskovitz-Eldor: Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells. in Developmental dynamics : an official publication of the American Association of Anatomists 2005
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Pig induced pluripotent stem cell (piPSC) line was generated from embryonic fibroblast cells using retroviral transduction approaches carrying human transcriptional factors: OCT4 (show POU5F1 Antibodies), SOX2 (show SOX2 Antibodies), KLF4 (show KLF4 Antibodies), c-MYC (show MYC Antibodies) and LIN28.
LIN28A is a sensitive IHC marker for the diagnosis of Embryonal Tumor with Multilayered Rosettes , but immunoreactivity can also be seen in a proportion of Atypical Teratoid/Rhabdoid Tumors
Recent improvement in high-throughput sequencing has highlighted the potential role of LIN28/let-7 regulatory network in several developmental events. It was proposed that this pathway might represent a functional signature in cell proliferation, transition between commitment and pluripotency, and regulation of cancer and tumorigenicity.
Knockdown of miR (show MLXIP Antibodies)-128a induces Lin28a expression and reverts myeloid differentiation blockage in acute myeloid leukemia (show BCL11A Antibodies).
Lin28A and Lin28B (show LIN28B Antibodies) are co-expressed colon cancer tissues and have functional similarities.
this study demonstrates that Lin28A can activates androgen receptor (show AR Antibodies) via regulation of c-myc (show MYC Antibodies) and promotes malignancy of ER-/Her2 (show ERBB2 Antibodies)+ breast cancer
The results suggest that the Lin28a gene enhances the osteoblastic differentiation of human periosteum-derived cells. In addition, the Lin28a gene increases mitochondrial activity in human periosteum-derived cells.
High LIN28A expression is associated with pancreatic cancer.
the specific interaction between zinc knuckle domain of LIN28 and pre-let-7 is necessary and sufficient to induce oligouridylation.
It has been shown that the constitutive expression of Lin28a during neuronal differentiation in vitro positively and negatively affects numerous miRNAs.
In the absence of Eprn, Lin28a expression is reduced which results in persistence of let-7 microRNAs, and the up-regulation of de novo methyltransferases Dnmt3a (show DNMT3A Antibodies)/b is delayed. Dnmt3a (show DNMT3A Antibodies)/b deletion retards ES cell transition, correlating with delayed Nanog (show NANOG Antibodies) promoter methylation and phenocopying loss of Eprn or Lin28a.
miR (show MLXIP Antibodies)-145 modulation of Sox2 (show SOX2 Antibodies)-Lin28/let-7 network is crucial for neurogenesis progression.
The results reveal a key role of Wnt (show WNT2 Antibodies)-Lin28-let7 miRNA signaling in regulating proliferation and neurogenic potential of Muller glial cells in the adult mammalian retina.
LIN28 specifically marks undifferentiated spermatogonia in mice. The LIN28-expressing undifferentiated spermatogonia exist as two subpopulations: Ngn3 (show NEUROG3 Antibodies)-GFP-negative (high stem cell potential) and Ngn3 (show NEUROG3 Antibodies)-GFP-positive (high differentiation commitment)
Overexpression of LIN28A, which is a hallmark of human ETMRs, augments Sonic-hedgehog (Shh (show SHH Antibodies)) and Wnt (show WNT2 Antibodies) signaling in embryonal tumors with multilayered rosettes precursor cells through the downregulation of let7-miRNA, and LIN28A/let7a interaction with the Shh (show SHH Antibodies) pathway was detected at the level of Gli (show GLI1 Antibodies) mRNA.
During ESC differentiation, Lin28 transient induction is dependent on Otx2 and Hmga2 and prevents an inappropriate excessive rise of Hmga2 levels.-
LIN28A and LIN28B (show LIN28B Antibodies) play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.
MAPK/ERK (show MAPK1 Antibodies) directly impacts LIN28, defining an axis that connects signalling, post-transcriptional gene control, and cell fate regulation.
Sirt1 (show SIRT1 Antibodies) knockdown abolished the protective effects of Lin28a against cardiac remodeling and dysfunction after MI, and Lin28a failed to increase the numbers of GFP-LC3 (show MAP1LC3A Antibodies)-positive punctae and decrease aggresome and p62 (show GTF2H1 Antibodies) accumulation in Sirt1 (show SIRT1 Antibodies)-knockdown neonatal cardiomyocytes subjected to hypoxia-induced injury.
the role of Lin28 in controlling developmental transitions is evolutionary conserved and establishes a functional interaction between Lin28 and thyroid hormone (show PTH Antibodies) function.
The knockdown of Lin-28a or Lin-28b (show LIN28B Antibodies) function by morpholino microinjection into embryos resulted in severe cell proliferation defects during early morphogenesis.
The Lin-28 is induced in Muller glia within 6 h following retinal injury and is necessary for Muller glia dedifferentiation.
Lin28 pseudogenes do not acquire patterns of tissue-specific methylation as for the parental gene, but rather are methylated in patterns specific to the local genomic environment into which they were inserted.
Dual-luciferase reporter assay validated that miR (show MYLIP Antibodies)-370, one of the 16 common microRNAs, could directly target the 3'UTR (show UTS2R Antibodies) of LIN28A.
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).
RNA-binding protein LIN-28
, protein lin-28 homolog A
, zinc finger CCHC domain-containing protein 1
, zinc finger, CCHC domain containing 1
, testis expressed gene 17
, testis-expressed protein 17
, RNA-binding protein LIN-28A
, RNA-binding protein lin-28
, lin-28 homolog A (C. elegans)