Lin-28 Homolog A (C. Elegans) ELISA Kit

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LIN28A Antigen Profile

Antigen Summary

Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).

Alternative names and synonyms associated with LIN28A

  • lin-28 homolog A (LIN28A) ELISA Kit
  • lin-28 homolog A (C. elegans) (Lin28a) ELISA Kit
  • lin-28 homolog A S homeolog (lin28a.S) ELISA Kit
  • lin-28 homolog A (C. elegans) (lin28a) ELISA Kit
  • lin-28 homolog A (Lin28a) ELISA Kit
  • lin-28 homolog A (lin28a) ELISA Kit
  • LIN-28 ELISA Kit
  • LIN28 ELISA Kit
  • lin-28A ELISA Kit
  • AL024421 ELISA Kit
  • ENSMUSG00000070700 ELISA Kit
  • Gm10299 ELISA Kit
  • Lin-28 ELISA Kit
  • Lin28 ELISA Kit
  • Tex17 ELISA Kit
  • csdd1 ELISA Kit
  • lin-28 ELISA Kit
  • lin28 ELISA Kit
  • zcchc1 ELISA Kit
  • sb:cb650 ELISA Kit
  • zgc:55584 ELISA Kit
  • RGD1566408 ELISA Kit

Protein level used designations for LIN28A

RNA-binding protein LIN-28 , protein lin-28 homolog A , zinc finger CCHC domain-containing protein 1 , zinc finger, CCHC domain containing 1 , testis expressed gene 17 , testis-expressed protein 17 , RNA-binding protein LIN-28A , lin-28A , RNA-binding protein lin-28 , Lin-28.1 , lin-28 homolog A (C. elegans) , lin-28-like

79727 Homo sapiens
83557 Mus musculus
387262 Xenopus laevis
394066 Danio rerio
428206 Gallus gallus
456661 Pan troglodytes
500562 Rattus norvegicus
548523 Xenopus (Silurana) tropicalis
612162 Canis lupus familiaris
614997 Bos taurus
100012320 Monodelphis domestica
100071098 Equus caballus
100142662 Sus scrofa
100302344 Ovis aries
100379627 Felis catus