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Human Polyclonal NANOG Primary Antibody for ChIP, ICC - ABIN188833
Hough, Clements, Welch, Wiederholt: Differentiation of mouse embryonic stem cells after RNA interference-mediated silencing of OCT4 and Nanog. in Stem cells (Dayton, Ohio) 2006
Show all 34 Pubmed References
Mouse (Murine) Polyclonal NANOG Primary Antibody for CyTOF, FACS - ABIN4899261
Parisi, Passaro, Aloia, Manabe, Nagai, Pastore, Russo: Klf5 is involved in self-renewal of mouse embryonic stem cells. in Journal of cell science 2008
Show all 15 Pubmed References
Human Polyclonal NANOG Primary Antibody for ICC, FACS - ABIN152020
Carey, Markoulaki, Hanna, Saha, Gao, Mitalipova, Jaenisch: Reprogramming of murine and human somatic cells using a single polycistronic vector. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 10 Pubmed References
Human Polyclonal NANOG Primary Antibody for IHC, ELISA - ABIN185444
Hyslop, Stojkovic, Armstrong, Walter, Stojkovic, Przyborski, Herbert, Murdoch, Strachan, Lako: Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. in Stem cells (Dayton, Ohio) 2005
Show all 14 Pubmed References
Human Polyclonal NANOG Primary Antibody for ICC, IF - ABIN258263
Aasen, Raya, Barrero, Garreta, Consiglio, Gonzalez, Vassena, Bili?, Pekarik, Tiscornia, Edel, Boué, Izpisúa Belmonte: Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. in Nature biotechnology 2008
Show all 7 Pubmed References
Human Monoclonal NANOG Primary Antibody for ELISA, FACS - ABIN316105
Moretti, Bellin, Jung, Thies, Takashima, Bernshausen, Schiemann, Fischer, Moosmang, Smith, Lam, Laugwitz: Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Show all 5 Pubmed References
Cow (Bovine) Polyclonal NANOG Primary Antibody for WB - ABIN2777175
Maimets, Neganova, Armstrong, Lako: Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells. in Oncogene 2008
Show all 4 Pubmed References
Cow (Bovine) Polyclonal NANOG Primary Antibody for WB - ABIN610568
Ku, Meier: Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells. in The Journal of biological chemistry 2000
Show all 3 Pubmed References
Human Monoclonal NANOG Primary Antibody for ELISA, WB - ABIN566403
Liu, Badeaux, Choy, Chandra, Shen, Jeter, Rycaj, Lee, Person, Liu, Chen, Shen, Jung, Qin, Tang: Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species. in PLoS ONE 2014
Show all 2 Pubmed References
Human Polyclonal NANOG Primary Antibody for IF (p), IHC (p) - ABIN728758
Liu, Li, Liu, Sui, Liu, Xiao, Zheng, Chen, Yao, Xing, Zhou, Li: A signature for induced pluripotent stem cell-associated genes in colorectal cancer. in Medical oncology (Northwood, London, England) 2013
Show all 2 Pubmed References
the epigenetic status of Oct4 and Nanog genes confirm that pre-induced pluripotent stem cells belong to an RVTg+OCT4+NANOG- state
In mouse embryonic stem cells, Cops2 binds to Nanog protein and prevent the degradation of Nanog by the proteasome.
Tip110 deletion impaired embryonic and stem cell development involving downregulation of stem cell factors Nanog, Oct4 (show POU5F1 Antibodies), and Sox2 (show SOX2 Antibodies).
Loss of phosphorylation enhances NANOG activity in reprogramming. Mutation S65A alone has the most significant impact on increasing NANOG reprogramming capacity.
Nanog, Oct4 (show POU5F1 Antibodies) and Tet1 (show TET1 Antibodies) interplay in establishing stem cell pluripotency has been described.
Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome.
Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains
Otx2 (show OTX2 Antibodies)-mediated Nanog regulation contributes to the integrity of the embryonic stem cell state and cell lineage specification in preimplantation development (show MTA2 Antibodies).
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4 (show POU5F1 Antibodies), Sox2 (show SOX2 Antibodies), and Nanog; Trim24 (show TRIM24 Antibodies) significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.
studies highlight a new hypoxia-induced pathway in which NANOG activates BNIP3L (show BNIP3L Antibodies) expression, contributing to autophagy induction in hypoxic tumor cells and their resistance to killing by CTL
These results demonstrate that analysis of IHC expression patterns of MK and NANOG in pretreatment biopsy specimens during the work-up period can provide a more definitive prognosis prediction for each oral squamous cell carcinoma (OSCC) patient that can help clinicians to develop a more precise individual treatment modality.
Chicken egg-white extracts promote OCT4 and NANOG expression and telomeres growth in 293T cells.
Rectal tumor tissue OCT4 (p<0.001), SOX2 (p=0.003), and NANOG (p<0.001) expressions were higher than those in adjacent tissue.
Data show that lung adenocarcinoma SPC-A1 cell differentiated by a two-stage induction (TSI) method lost stem cell characteristics, including absent expression of OCT4 and Nanog.
Ino80 was upregulated in cervical cancer and promoted cell proliferation and tumorigenesis by binding to the Nanog transcription start site and enhancing its expression.
our data suggest that 3D culture increases the expression of Nanog through the relaxation of actin cytoskeleton, which mediates reduced Suv39h1 (show SUV39H1 Antibodies) and H3K9me3 levels.
results show that NANOG could reverse the effects of stem cell senescence and restore the myogenic differentiation potential of senescent MSCs.
MACC1 (show MACC1 Antibodies)-induced tumor progression in colorectal cancer acts, at least in part, via the newly discovered MACC1 (show MACC1 Antibodies)/Nanog/Oct4 (show POU5F1 Antibodies) axis.
RNAi-mediated silencing of NANOG in SKOV-3 reversed the expression of mesenchymal cell markers and restored expression of E-cadherin. Susceptibility to cisplatin increased in SKOV-3 cells on down-regulating NANOG and reversible results were obtained in Moody cells post-overexpression of NANOG.
NANOG enabled reactivation of the ROCK and Transforming Growth Factor (TGF)-beta pathways-both of which were impaired in senescent cells-leading to ACTIN polymerization, MRTF-A translocation into the nucleus and serum response factor (SRF)-dependent myogenic gene expression.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Nanog displayed relatively the same methylation levels between sperm and oocytes
Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.
Activin A (show INHBA Antibodies) and overexpression of SMAD2 (show SMAD2 Antibodies)/3 significantly promoted expressions of porcine NANOG and OCT4 (show POU5F1 Antibodies),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog/OCT4 (show POU5F1 Antibodies) expression.
the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.
Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.
Localisation of NANOG, OCT4 (show POU5F1 Antibodies), and E-CADHERIN (show CDH1 Antibodies) in porcine pre- and peri (show PLIN1 Antibodies)-implantation embryos.
NANOG and SOX2 (show SOX2 Antibodies) expression inversely correlated with the DNA methylation (show HELLS Antibodies) pattern in the promoter region
report the isolation of complete coding regions of rabbit SOX2, KLF4, C-MYC and NANOG, which encode transcription factors that play crucial regulatory roles during early mammalian embryonic development
Nanog suppresses the expression of vasa (show DDX4 Antibodies) by directly regulating nlk1 (show NLK Antibodies) in the early zebrafish embryo
findings suggest that maternal Nanog coordinates several gene regulatory networks that shape the embryo during gastrulation.
These results indicate that zebrafish Nanog is necessary for proper yolk syncytial layer development but is not directly required for embryonic cell differentiation.
The authors show, at single-cell resolution in vivo, that Pou5f3 complexes with Nanog to pattern mesendoderm differentiation at the blastula stage.
Nanog has a role in supressing cell migration.
maternal Nanog, Pou5f1 (show POU5F1 Antibodies) and SoxB1 are required to initiate the zygotic developmental program and induce clearance of the maternal program by activating miR (show MYLIP Antibodies)-430 expression
Depletion of Nanog in zebrafish cannot be rescued by ectopic expression of Xvent, and Xvent depletion in Xenopus cannot be overcome by ectopic expression of zebrafish Nanog.
This study identified a Nanog-like-Mxtx2-Nodal pathway and establishes a role for Nanog-like in regulating the formation of the extraembryonic tissue required for endoderm induction.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
ES cell-associated protein 4
, early embryo specific expression NK family
, early embryo specific expression NK-type homeobox protein
, homeobox protein NANOG
, homeobox transcription factor Nanog
, homeobox transcription factor Nanog-delta 48
, homeobox transcription factor NANOG
, Nanog homeobox
, nanog homeobox transcription factor
, homeodomain transcription factor Nanog
, LOW QUALITY PROTEIN: homeobox protein NANOG
, nanog homeobox
, ovary-expressed homeobox protein