Browse our anti-Nucleoporin 98kDa (NUP98) Antibodies

Full name:: anti-Nucleoporin 98kDa Antibodies (NUP98)

On www.antibodies-online.com are 67 Nucleoporin 98kDa (NUP98) Antibodies from 16 different suppliers available. Additionally we are shipping Nucleoporin 98kDa Kits (18) and Nucleoporin 98kDa Proteins (10) and many more products for this protein. A total of 102 Nucleoporin 98kDa products are currently listed.

Synonyms:: 4732457F17, ADIR2, AI849286, CG10198, CG10201, Dmel\\CG10198, GB12688, im:7151238, l(3)95BCd, Nup-98, Nup 96, NUP96, NUP98, Nup 98, nup98-96, Nup98-Nup96, Nup98/96, nup145, NUP196, zgc:63593, zgc:113968

list all antibodies	Gene Name	GeneID	UniProt
	NUP98	269966
	NUP98	81738	P49793
	NUP98	4928	P52948
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Top referenced anti-Nucleoporin 98kDa Antibodies

Human Monoclonal NUP98 Primary Antibody for IF, WB - ABIN2452064 : Iwamoto, Asakawa, Hiraoka, Haraguchi: Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms. in Genes to cells : devoted to molecular & cellular mechanisms 2010 (PubMed)
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Human Monoclonal NUP98 Primary Antibody for IF, WB - ABIN2452065 : Iwamoto, Asakawa, Ohtsuki, Osakada, Koujin, Hiraoka, Haraguchi: Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans. in Monoclonal antibodies in immunodiagnosis and immunotherapy 2013 (PubMed)
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Human Monoclonal NUP98 Primary Antibody for DB, ICC - ABIN2452066 : Fukuhara, Ozaki, Shikata, Katahira, Yoneda, Ogino, Tachibana: Specific monoclonal antibody against the nuclear pore complex protein, nup98. in Hybridoma (2005) 2005 (PubMed)
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Human Polyclonal NUP98 Primary Antibody for IP, WB - ABIN408604 : Franks, Benner, Narvaiza, Marchetto, Young, Malik, Gage, Hetzer: Evolution of a transcriptional regulator from a transmembrane nucleoporin. in Genes & development 2016 (PubMed)

More Antibodies against Nucleoporin 98kDa Interaction Partners

Fruit Fly (Drosophila melanogaster) Nucleoporin 98kDa (NUP98) interaction partners

The distribution of Moesin (show MSN Antibodies) in the nucleus suggests a function in transcription and the depletion of mRNA export factors Nup98 or its interacting partner, Rae1 (show RAE1 Antibodies), leads to the nuclear accumulation of Moesin (show MSN Antibodies), suggesting that the nuclear function of the protein is linked to mRNA export
Nup98 provides a scaffold for poised genes and mediates Induced enhancer-promoter contacts in genetic transcription.
Nup98 associates and colocalizes with the MBD (show DPEP1 Antibodies)-R2/NSL and Trx (show GSR Antibodies) complexes. Nup98 regulates transcription of Trx (show GSR Antibodies) targets, the Hox (show MSH2 Antibodies) genes.
Nup98, a virus-induced gene, was antiviral against a panel of viruses.
Study analyzed genomic interactions of full-length nucleoporins Nup98, Nup50 (show NUP50 Antibodies), and Nup62 and found that they predominantly interacted with active genes inside the nucleoplasm, particularly those involved in developmental regulation and the cell cycle.
Nup88 (show NUP88 Antibodies) localizes to silent loci, Sec13 (show SEC13 Antibodies), Nup98, and a subset of FG-repeat nucleoporins bind to developmentally regulated genes undergoing transcription induction.

Mouse (Murine) Nucleoporin 98kDa (NUP98) interaction partners

We demonstrated that Nup98-TopIIbeta and Nup98-SETBP1 (show SETBP1 Antibodies) negatively regulate the XPO1 (show XPO1 Antibodies)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98-fusion proteins induce tumorigenesis.
The age-associated accumulation of somatic mutations that occurs in the Nup98-HOXD13 (show HOXD13 Antibodies) (NHD13) mouse model of leukemia progression was significantly elevated by co-expression of a PKR (show EIF2AK2 Antibodies) transgene.
Nup50 (show NUP50 Antibodies) dynamics are independent of importin alpha, Nup153 (show NUP153 Antibodies), and Nup98, even though the latter two proteins also exhibit transcription-dependent mobility.
Data indicate that loss of cyclin-dependent kinase inhibitor p15 (p15Ink4b (show CDKN2B Antibodies)) collaborates with oncogene (show RAB1A Antibodies) fusion protein Nup98-HoxD13 (show HOXD13 Antibodies) transgene in the development of predominantly myeloid neoplasms.
Homeobox (show PRRX1 Antibodies) partners create more potent NUP98 fusion oncogenes than do non-homeobox (show PRRX1 Antibodies) partners.
findings show that expression of NUP98-HOXD13 (show HOXD13 Antibodies) impairs class switch recombination and reduces the antibody-mediated immune response, in addition to its role in leukemia
Mice expressing both the FLT3 (show FLT3 Antibodies)/ITD and Nup98-HoxD13 (show HOXD13 Antibodies) (NHD13) fusion gene developed acute myeloid leukemia (show BCL11A Antibodies) with 100% penetrance
Data show that NUP98-HOXA10HD, a novel, canonical NUP98-Hox (show MSH2 Antibodies) fusion, significantly enhances the self-renewal capacity of hematopoietic stem cells.
These results clearly demonstrate that Nup98 functions as a novel shuttling cofactor for Crm1 (show XPO1 Antibodies)-mediated nuclear export in conjunction with RanBP3 (show RANBP3 Antibodies).
A mouse model of CML blast crisis induced by cooperation between BCR/ABL (show ABL1 Antibodies) and NUP98/HOXA9 (show HOXA9 Antibodies)

Zebrafish Nucleoporin 98kDa (NUP98) interaction partners

data show that a novel nup98 was identified and it serves a role in nucleocytoplasmic trafficking similar to human NUP98.

Human Nucleoporin 98kDa (NUP98) interaction partners

human NUP98-IQCG fusion protein could induce fatal and transplantable acute myelomonocytic leukemia in a mouse model
Importantly, binding of Nup98 to DHX9 stimulates the ATPase activity of DHX9, and a transcriptional reporter assay suggests Nup98 supports DHX9-stimulated transcription.
The second FG repeat domain of the NUP98 moiety of the NUP98-HOXA9 (show HOXA9 Antibodies) fusion protein is important for its cell immortalization and leukemogenesis activities. NUP98-HOXA9 (show HOXA9 Antibodies) interacts with mixed lineage leukemia (MLL (show MLL Antibodies)) via this FG repeat domain and that, in MLL (show MLL Antibodies)-null mice, NUP98-HOXA9 (show HOXA9 Antibodies)-induced cell immortalization and leukemogenesis are severely inhibited.
DYNLT1 (show DYNLT1 Antibodies) interacts with nucleoporins and plays a role in the dysregulation of gene expression and induction of hematopoietic cell proliferation by the leukemogenic nucleoporin (show AGFG2 Antibodies) fusion, NUP98-HOXA9 (show HOXA9 Antibodies)
the mutation order in the NUP98-rearranged pediatric AML (show RUNX1 Antibodies) begins with the NUP98 rearrangement leading to epigenetic dysregulations then followed by mutations of critical hematopoietic transcription factors and finally, activation of the FLT3 (show FLT3 Antibodies) signaling pathway.
These results provide novel insight into the mechanisms underlying the aberrant capability of NUP98 oncoproteins to interact with APC (show APC Antibodies)/C(Cdc20 (show CDC20 Antibodies)) and to interfere with its function.
Our results suggest that NA10HD increases the number of gamma-globin-transduced HSCs that engraft, leading to an elevated number of fetal hemoglobin-containing red cells.
NUP98-HOXA9 (show HOXA9 Antibodies) ability to induce blood cell expansion is evolutionarily conserved.
The study demonstrated the association of NUP98-IQCG with CRM1, and found that NUP98-IQCG expression inhibits the CRM1-mediated nuclear export of p65 and enhances the transcriptional activity of nuclear factor-kappaB. Moreover, IQCG could be entrapped in the nucleus by NUP98-IQCG, and the fusion protein interacts with calmodulin via the IQ motif in a calcium-independent manner.
The results indicate that highly selective targeting of Nup98-fusion proteins to Hox (show MSH2 Antibodies) cluster regions via prebound Crm1 (show XPO1 Antibodies) induces the formation of higher order chromatin structures that causes aberrant Hox (show MSH2 Antibodies) gene regulation.

Xenopus laevis Nucleoporin 98kDa (NUP98) interaction partners

These data support a model in which Nup98 interacts with microtubules and antagonizes MCAK (show KIF2C Antibodies) activity, thus promoting bipolar spindle assembly.

Nucleoporin 98kDa (NUP98) Antigen Profile

Antigen Summary

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described.

Alternative names and synonyms associated with Nucleoporin 98kDa (NUP98)

Nucleoporin 98-96kD (Nup98-96) antibody
nuclear pore complex protein Nup98-Nup96 (LOC408335) antibody
nucleoporin 98 (NUP98) antibody
nuclear pore complex protein Nup98-Nup96 (LOC587580) antibody
nucleoporin 98kDa (NUP98) antibody
nucleoporin 98 (Nup98) antibody
nucleoporin 98 (nup98) antibody
nucleoporin 98 L homeolog (nup98.L) antibody

4732457F17 antibody
ADIR2 antibody
AI849286 antibody
CG10198 antibody
CG10201 antibody
Dmel\\CG10198 antibody
GB12688 antibody
im:7151238 antibody
l(3)95BCd antibody
Nup-98 antibody
Nup 96 antibody
NUP96 antibody
NUP98 antibody
Nup 98 antibody
nup98-96 antibody
Nup98-Nup96 antibody
Nup98/96 antibody
nup145 antibody
NUP196 antibody
zgc:63593 antibody
zgc:113968 antibody

Protein level used designations for NUP98

, , , , , , , , , , , , , , , , , , CG10198-PA CG10198-PC CG10198-PD Nup98 Nup98-96-PA Nup98-96-PC Nup98-96-PD nucleoporin 98 nucleoporin 98-96 nucleoporin98-96 nucleoporin 98kD nucleoporin 98kDa nuclear pore complex protein Nup98-Nup96-like nuclear pore complex protein Nup98-Nup96 98 kDa nucleoporin nuclear pore complex protein Nup98 nucleoporin Nup98 GLFG-repeat containing nucleoporin Nup98-Nup96

GENE ID	SPECIES
42816	Drosophila melanogaster
408335	Apis mellifera
450971	Pan troglodytes
587580	Strongylocentrotus purpuratus
100016427	Monodelphis domestica
100052986	Equus caballus
100090367	Ornithorhynchus anatinus
100414799	Callithrix jacchus
100475098	Ailuropoda melanoleuca
100522560	Sus scrofa
269966	Mus musculus
81738	Rattus norvegicus
777756	Danio rerio
430616	Gallus gallus
4928	Homo sapiens
476822	Canis lupus familiaris
540004	Bos taurus
100343626	Oryctolagus cuniculus
446233	Xenopus laevis

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