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anti-Rat (Rattus) PHF19 Antibodies:
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miR-124a suppresses PHF19 over-expression, EZH2 hyper-activation, and aberrant glioma cell proliferation
G9a promotes H3K27 methylation of the E-cadherin promoter by upregulating PCL3 to increase PRC2 promoter recruitment and by downregulating the H3K27 demethylase KDM7A to silence E-cadherin gene
These results provide evidence that PHF19 promotes Hepatocellular carcinoma and is regulated by the tumor-suppressor, miR-195-5p
The histone H3K36me3 binding by the Tudor domains of PHF1, PHF19 and likely MTF2 provide another recruitment and regulatory mechanism for the PRC2 complex
propose a model whereby PHF19 functions during mouse embryonic stem cell differentiation to transiently bind the H3K36me3 mark via its Tudor domain
PHF19 silencing reduces the cell proliferation rate and increases the transendothelial migration capacities of melanoma cell lines.
Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes
identification of a gene encoding a human homologue of the Drosophila polycomblike protein, hPCL3 gene, encoding two nuclear proteins, hPCL3S and hPCL3L; markedly overexpressed in many types of cancers
Acts as a transcritpional repressor. Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
PHD finger protein 19
, PHD finger protein 19-like
, polycomb like 3
, polycomb-like 3
, polycomb-like protein 3
, tudor domain containing 19B