Browse our PLA2G2A Proteins (PLA2G2A)

Human phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) interaction partners

1. sPLA2 appears to play an important role in the pathogenesis of dengue. We found that sPLA2 activity was significantly higher in patients with dengue haemorrhagic fever when compared to those with dengue fever, during the first 120 h of clinical illness.

2. The findings of this study showed that maslinic acid inhibit inflammatory effects induced by sPLA2-IIA, including foam cells formation and PGE2 production.

3. High PLA2 (show YWHAZ Proteins) activity is associated with West Nile virus infection.

4. A lipidomics-based LC/MS assay was used to define the specificity of cPLA2 (show PLA2G4A Proteins), iPLA2 (show PLA2G6 Proteins), and sPLA2 toward a variety of phospholipids. A unique hydrophobic binding site for the cleaved fatty acid dominates each enzyme's specificity rather than its catalytic residues and polar headgroup binding site.

5. demonstration of an independent association between early-stage atherosclerosis and increased levels of sPLA2-IIa, implying that increased sPLA2-IIa may have a role in early-stage atherosclerosis in MetS (show ETV3 Proteins) patients

6. these results suggest that PLA2G2A polymorphisms are involved in the risk of developing metabolic syndrome and type 2 diabetes mellitus and are associated with subclinical atherosclerosis in this group of patients

7. PLA2G2A has a previously undiscovered impact on insulin (show INS Proteins) sensitivity and metabolism

8. lipidomic analyses revealed that sequestration of PUFAs in LDs by sPLA2-induced TAG remodelling and retention of PUFAs in LDs by inhibition of ATGL (show PNPLA2 Proteins)-mediated TAG lipolysis protect from PUFA lipotoxicity.

9. This report provides the first demonstration that Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group IIA, V and X Secretory Phospholipases A2.

10. Given an aberrant high level of sPLA2IIa in the tumor microenvironment that should be much higher than that in the blood, our findings support the notion that sPLA2IIa functions as a ligand for EGFR (show EGFR Proteins) family receptors and supports CSC properties via HER/ERBB (show EGFR Proteins)-elicited signaling, which may contribute to resistance to therapy and cancer progression

Mouse (Murine) phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) interaction partners

1. transgenic mice overexpressing sPLA2 -IIA keratinocytes showed enhanced activation of EGFR (show EGFR Proteins) and JNK1 (show MAPK8 Proteins)/2 that led to c-Jun (show JUN Proteins) activation.

2. PLA2 promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection.

3. secretory PLA2s have important functions as genetic modifiers of inflammation and colon cancer.

4. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ Proteins), lipoxygenase and cyclooxygenase.

5. Polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.

6. Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2beta (iPLA2beta (show PLA2G6 Proteins)) and Group X Secreted Phospholipase A2 (show YWHAZ Proteins) (sPLA2).

7. Data show that the coordinated action of phospholipase A2 (show YWHAZ Proteins) IIA (sPLA2-IIA) and 12-lipoxygenase (12-LO (show ALOX15 Proteins)) promotes inflammatory arthritis.

8. Pla2g2a sequence varies between tumor resistant and sensitive mouse strains. Some of these variations in the promoter region affect Pla2g2a expression and nonsense-mediated RNA decay also contributes to reducing Pla2g2a mRNA in tumor-sensitive strains.

9. hydrolysis of the mitochondrial membrane by sPLA2-IIA yields inflammatory mediators (ie, lysophospholipids, fatty acids, and mtDNA) that promote leukocyte activation

10. Ionomycin causes susceptibility to phospholipase A2 while temperature-induced increases in membrane fluidity fail: possible involvement of actin fragmentation.

Guinea Pig phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) interaction partners

1. PLA2G2A production is induced by Pseudomonas aeruginosa.