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anti-Human RIF1 Antibodies:
anti-Mouse (Murine) RIF1 Antibodies:
anti-Rat (Rattus) RIF1 Antibodies:
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Human Polyclonal RIF1 Primary Antibody for IHC, IP - ABIN151132
Arora, Brun, Azzalin: Transcription regulates telomere dynamics in human cancer cells. in RNA (New York, N.Y.) 2012
Show all 3 Pubmed References
Human Polyclonal RIF1 Primary Antibody for ELISA - ABIN268794
Silverman, Takai, Buonomo, Eisenhaber, de Lange: Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. in Genes & development 2004
Human Polyclonal RIF1 Primary Antibody for ELISA, WB - ABIN4350533
Wang, Zhao, Chen, Zhong, Liao, Gao, Cai, Lee, Li, Chowdhury, Yang, Pfeifer, Yen, Xu: Human RIF1 encodes an anti-apoptotic factor required for DNA repair. in Carcinogenesis 2009
Data suggest that SCAI (show SCAI Antibodies) inhibits RIF1 (show INSL6 Antibodies) function to allow BRCA1-mediated repair, which possibly includes alt-NHEJ and resection-dependent NHEJ in G1, as well as HDR (show GATA3 Antibodies) in S/G2 (show STRN3 Antibodies).
53BP1 (show TP53BP1 Antibodies)/RIF1 (show INSL6 Antibodies) has a role in limiting BRCA1/CtIP (show RBBP8 Antibodies)-mediated end resection to control double strand break repair pathway choice
Rif1 (show INSL6 Antibodies) can mediate MCM dephosphorylation at replication forks and that the stability of dephosphorylated replisomes strongly depends on Chk1 (show CHEK1 Antibodies) activity.
DDX1 (show DDX1 Antibodies), a RNA helicase (show DDX46 Antibodies) also implicated in DSB repair, interacts with RIF1 (show INSL6 Antibodies). Recruitment of DDX1 (show DDX1 Antibodies) to DSBs is dependent on RIF1 (show INSL6 Antibodies). DDX1 (show DDX1 Antibodies) and RIF1 (show INSL6 Antibodies) have different nucleic acid requirements for accumulation at DSBs, with RNA-DNA hybrids required for DDX1 (show DDX1 Antibodies) accrual at DSBs, and single-strand RNA required for accumulation of RIF1 (show INSL6 Antibodies) at these sites.
In pancreatic cancer cells, RIF1 (show INSL6 Antibodies) gene expression in the stem cell-positive cell line was 256 times that seen in the stem cell-negative cell line. RIF1 (show INSL6 Antibodies) may be one of the genes that plays an important role in the diagnoses and therapeutic treatment of pancreatic cancer
These data reveal a thus far unrecognized function for Rif1 (show INSL6 Antibodies) in the resolution of ultrafine DNA bridges during anaphase to protect genomic integrity.
RIF1 (show INSL6 Antibodies) is an important component in DNA damage response signaling. [Review]
RIF1 (show INSL6 Antibodies) not only acts downstream of 53BP1 (show TP53BP1 Antibodies) and counteracts BRCA1-mediated end resection but also has a secondary role in promoting BLM (show BLM Antibodies) function in DNA repair.
RIF1 (show INSL6 Antibodies) as the critical effector of 53BP1 (show TP53BP1 Antibodies) during DSB repair
Rif1 (show INSL6 Antibodies) plays crucial roles in determining the replication timing domain structures in human cells through regulating higher-order chromatin architecture
Findings indicate an essential role of telomere-associated protein Rif1 in the epigenetic defense against endogenous retroviruses (ERVs) activation.
This study identifies Rif1 as the molecular link between nuclear architecture and replication-timing establishment in mammals.
Oct4 (show POU5F1 Antibodies) recruits Smad3 (show SMAD3 Antibodies) to bind to Rif1 promoter, but Smad3 (show SMAD3 Antibodies) joining facilitates the loading of a polycomb (show CBX2 Antibodies) complex that generates a repressive epigenetic modification on Rif1 promoter and maintains the expression of Rif1 in embryonic stem cells.
structural study of the mammalian Rif1
Rif1 negatively modulates Zscan4 (show ZSCAN4 Antibodies) expression by maintaining H3K9me3 levels at subtelomeric regions. Rif1 interacts and stabilizes H3K9 methylation complex.
Study concludes that 53BP1 (show TP53BP1 Antibodies) promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP (show PAXIP1 Antibodies).
Rif1(-/-) mice are severely compromised for 53BP1 (show TP53BP1 Antibodies)-dependent class switch recombination (CSR (show SCARA3 Antibodies)) and fusion of dysfunctional telomeres.
data establish Rif1 as an important contributor to the control of double-strand break repair by 53BP1 (show TP53BP1 Antibodies)
study identifies Rif1 as an ATM (show ATM Antibodies) phosphorylation-dependent interactor of 53BP1 (show TP53BP1 Antibodies) and shows that absence of Rif1 results in 5'-3' DNA-end resection; Rif1 deficiency impairs DNA repair in cell cycle G(1) and S phases, interferes with immunoglobulin class switchnig and leads to accumulation of chromosome double strand breaks
Rif1 is a key regulator of the replication-timing programme in mammalian cells
This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants.
rap1-interacting factor 1 homolog
, telomere-associated protein RIF1
, Rap1 interacting factor 1 homolog
, RAP1 interacting factor homolog (yeast)
, RAP1 interacting factor 1
, telomere-associated protein RIF1-like