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anti-Human RIF1 Antibodies:
anti-Mouse (Murine) RIF1 Antibodies:
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Human Polyclonal RIF1 Primary Antibody for IHC, IP - ABIN151132
Arora, Brun, Azzalin: Transcription regulates telomere dynamics in human cancer cells. in RNA (New York, N.Y.) 2012
Show all 3 Pubmed References
Human Polyclonal RIF1 Primary Antibody for ICC, IF - ABIN151131
Wang, Zhao, Chen, Zhong, Liao, Gao, Cai, Lee, Li, Chowdhury, Yang, Pfeifer, Yen, Xu: Human RIF1 encodes an anti-apoptotic factor required for DNA repair. in Carcinogenesis 2009
Human Polyclonal RIF1 Primary Antibody for ELISA - ABIN268794
Silverman, Takai, Buonomo, Eisenhaber, de Lange: Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. in Genes & development 2004
Dog (Canine) Polyclonal RIF1 Primary Antibody for ELISA, WB - ABIN538414
Adams, McLaren: Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells. in Developmental dynamics : an official publication of the American Association of Anatomists 2004
data suggest that CST-Polalpha-mediated fill-in helps to control the repair of double-strand breaks by 53BP1, RIF1 and shieldin
Low Rap1-interacting factor 1 expression is associated with Hodgkin lymphoma.
Upregulation of RIF1 correlates with poor prognosis in Epithelial Ovarian Cancer.
Data suggest that SCAI inhibits RIF1 function to allow BRCA1-mediated repair, which possibly includes alt-NHEJ and resection-dependent NHEJ in G1, as well as HDR in S/G2.
53BP1/RIF1 has a role in limiting BRCA1/CtIP-mediated end resection to control double strand break repair pathway choice
Rif1 can mediate MCM dephosphorylation at replication forks and that the stability of dephosphorylated replisomes strongly depends on Chk1 activity.
DDX1, a RNA helicase also implicated in DSB repair, interacts with RIF1. Recruitment of DDX1 to DSBs is dependent on RIF1. DDX1 and RIF1 have different nucleic acid requirements for accumulation at DSBs, with RNA-DNA hybrids required for DDX1 accrual at DSBs, and single-strand RNA required for accumulation of RIF1 at these sites.
In pancreatic cancer cells, RIF1 gene expression in the stem cell-positive cell line was 256 times that seen in the stem cell-negative cell line. RIF1 may be one of the genes that plays an important role in the diagnoses and therapeutic treatment of pancreatic cancer
These data reveal a thus far unrecognized function for Rif1 in the resolution of ultrafine DNA bridges during anaphase to protect genomic integrity.
RIF1 is an important component in DNA damage response signaling. [Review]
RIF1 not only acts downstream of 53BP1 and counteracts BRCA1-mediated end resection but also has a secondary role in promoting BLM function in DNA repair.
RIF1 as the critical effector of 53BP1 during DSB repair
Rif1 plays crucial roles in determining the replication timing domain structures in human cells through regulating higher-order chromatin architecture
Rif1 functions in the intra-S-phase checkpoint that serves to slow down DNA synthesis when DNA damage has occurred.
In telophase, hRif1 localized to chromosomes, and in interphase, it was intranuclear. These results define a novel subcellular localization behavior for hRif1 during the cell cycle.
High RIF1 expression is associated with breast tumors.
Data support model in which Rif1 modulates chromatin loop structures through binding to multiple G-quadruplex assemblies and by holding chromatin fibers together.
Rif1 is a high-affinity binding partner of protein phosphatase 1.
Knockdown of RIF1 increases cisplatin sensitivity in vivo in Epithelial Ovarian Cancer.
Findings indicate an essential role of telomere-associated protein Rif1 in the epigenetic defense against endogenous retroviruses (ERVs) activation.
This study identifies Rif1 as the molecular link between nuclear architecture and replication-timing establishment in mammals.
Oct4 recruits Smad3 to bind to Rif1 promoter, but Smad3 joining facilitates the loading of a polycomb complex that generates a repressive epigenetic modification on Rif1 promoter and maintains the expression of Rif1 in embryonic stem cells.
structural study of the mammalian Rif1
Rif1 negatively modulates Zscan4 expression by maintaining H3K9me3 levels at subtelomeric regions. Rif1 interacts and stabilizes H3K9 methylation complex.
Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP.
Rif1(-/-) mice are severely compromised for 53BP1-dependent class switch recombination (CSR) and fusion of dysfunctional telomeres.
data establish Rif1 as an important contributor to the control of double-strand break repair by 53BP1
study identifies Rif1 as an ATM phosphorylation-dependent interactor of 53BP1 and shows that absence of Rif1 results in 5'-3' DNA-end resection; Rif1 deficiency impairs DNA repair in cell cycle G(1) and S phases, interferes with immunoglobulin class switchnig and leads to accumulation of chromosome double strand breaks
Rif1 is a key regulator of the replication-timing programme in mammalian cells
Rif1 has a role in the repair of stalled replication forks by facilitating homology-directed repair.
This is a mouse ortholog of the yeast Rif1 family of telomere-associated proteins identified on the basis of its high expression in primordial germ cells and embryo-derived pluripotent stem cell lines.
This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants.
rap1-interacting factor 1 homolog
, telomere-associated protein RIF1
, Rap1 interacting factor 1 homolog
, RAP1 interacting factor homolog (yeast)
, RAP1 interacting factor 1
, telomere-associated protein RIF1-like