Browse our SAV1 Proteins (SAV1)

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

• salvador family WW domain containing protein 1 (SAV1)
• salvador family WW domain containing 1 (Sav1)
• salvador family WW domain containing protein 1 (Sav1)

• 1700040G09Rik protein
• Salv protein
• Sav protein
• WW45 protein
• Wwp3 protein
• Show all synonym aliases
• Wwp4 protein

1700040G09Rik , 45 kDa WW domain protein , WW domain-containing , hWW45 , protein salvador homolog 1 , WW domain-containing protein 3 , WW domain-containing protein 4 , Salvador homolog 1 protein , rWW45