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Significant CYP1A1 expression increases over control animals was observed in ileum tissue in swine exposed to a single dose of 10 mgkg-bw-1 PAHs
There was no association between CYP1A1 C genotype and survival in the overall study population
The effect of human chorionic gonadotropin on the activities of cytochrome P-450 CYP1A1, cytochrome P-450 CYP2B1 and methoxyresorufin O-demethylase (MROD) was studied in intact male pigs of 2 breeds.[CYP2B1; MROD]
This study demonstrated for the first time that the serum testosterone level is one of the physiological factors which regulate constitutive expression of hepatic CYP1A1 and CYP1A2 (show CYP1A2 Proteins) in pigs.
The findings demonstrate a gender-related difference in the constitutive expression of hepatic CYP1A1 in Meishan pigs and further indicate that testosterone down-regulates the constitutive gene expression of the enzyme.
Distinct subtypes of urinary bladder epithelial cells with inducible and non-inducible cytochrome P-450 CYP1A1 are reported.
Effect of beta-napthoflavone on AHR (show AHR Proteins)-related gene, CYP1A1, in the pig is reported.
CYP1A1 has an oncogenic role in prostate cancer via promoter hypomethylation that is influenced by tobacco smoking
Utilising a three-dimensional lymph endothelial cell (LEC) monolayer & MDA-MB231 breast cancer cell spheroid co-culture model in combination with knock-down approach allowed elucidation of the molecular/biochemical basis of AHR (show AHR Proteins)/CYP1A1-induced tumour breaching through the LEC barrier.
This meta-analysis demonstrated CYP1A1 rs1048943 A>G may increase the susceptibility to colorectal cancer (CRC (show CALR Proteins)) instead of rs4646903 T> C. This conclusion suggested CYP1A1 may contribute to the pathogenesis of CRC (show CALR Proteins). [meta-analysis]
The Rs4646903 polymorphism of CYP1A1 is Associated with Recurrent Pregnancy Loss, especially among South Asians.
We demonstrated that infants whose mothers smoked during pregnancy with the combination of AHR (show AHR Proteins), CYP1A1, and XRCC1 (show XRCC1 Proteins) polymorphisms had lower birth size.
genetic variations in STX1B (show STX1B Proteins), DNMT3A (show DNMT3A Proteins) and CYP1A1 have roles in influencing warfarin maintenance dose
CYP1A1 rs2606345 influences response to anticonvulsants in North Indian women with epilepsy by lowering CYP1A1 expression.
This is the first report providing evidence of hyperoxia-mediated transcriptional activation of the human CYP1A1 promoter in newborn mice, and this in conjunction with decreased lung injury, suggests that these phenomena have important implications for bronchopulmonary dysplasia.
Review/Meta-analysis: CYP1A1 T3801C and A2455G variants might not be risk alleles for breast cancer susceptibility in Chinese individuals.
These findings identify a role for pattern recognition receptor (PRR) signaling in regulating the AHR response through selective down-regulation of Cyp1 expression in human monocytes and macrophages.
Miroestrol suppressed beta-naphthoflavone increases in CYP1A1.
Taken together, CAPE decreases 3-MC-mediated CYP1A1 expression, and this inhibitory response is associated with inhibition of AhR (show AHR Proteins) and HIF-1alpha (show HIF1A Proteins) induction.
Our results support the hypothesis that CYP1A1 protects against hyperoxic lung injury by decreasing oxidative stress.
CYP1A1 contributes to nitric oxide bioavailability and blood pressure regulation mediated by dietary omega-3 polyunsaturated fatty acids.
Aryl hydrocarbon receptor (show AHR Proteins) mediated induction of hepatic CYP1A1/1A2 is dependent on the presence of ctnnb1 (show CTNNB1 Proteins).
Suggest that CYP1A induction by coplanar polychlorinated/brominated biphenyls depends on AhR (show AHR Proteins) transcriptional activity and not on AhR (show AHR Proteins) expression.
Identify hepatic proteins necessary for the AHR (show AHR Proteins)-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
In livers of HRN mice Cyp1a1, cytochrome b5 (show CYB5A Proteins) and mEH (show EPHX1 Proteins) can effectively activate BaP (show PHB2 Proteins) to DNA binding species, even in the presence of very low amounts of P450 (show POR Proteins) oxidoreductase (show HSD17B6 Proteins).
Reactive oxygen species production contributes to benzo[a]pyrene (BaP (show PHB2 Proteins))-exacerbated atherosclerosis and CYP1A1 plays a protective role against oral BaP (show PHB2 Proteins) toxicity in aorta
harmine and harmaline are promising candidate to inhibit TCDD-mediated induction of Cyp1a1 in mice hepatic and extrahepatic tissues
CYP1A1 and CYP1A2 (show CYP1A2 Proteins) localization into different lipid microdomains is governed by their N-terminal and internal protein regions
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown\; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
cytochrome P450 1A1
, cytochrome P450 CYP1A1
, aryl hydrocarbon hydroxylase
, cytochrome P1-450, dioxin-inducible
, cytochrome P450 form 6
, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
, cytochrome P450-C
, cytochrome P450-P1
, flavoprotein-linked monooxygenase
, xenobiotic monooxygenase
, cytochrome P1-450
, cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c)
, cytochrome P450, 1a1
, cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c)
, cytochrome P450MT2
, microsomal monooxygenase
, aromatic compound inducible
, cytochrome P450 family 1 subfamily a polypeptide 2
, cytochrome P450 subfamily I, polypeptide 1
, cytochrome P450, 1a1, aromatic compound inducible
, P-450 PHPAH1
, P450 LM6
, P450 isozyme 6
, cytochrome P-450 PHPAH1
, cytochrome P450 LM6
, cytochrome P450 isozyme 6